HIFU for Noninvasive Abscess Treatment

HIFU 无创脓肿治疗

基本信息

批准号：
9120875
负责人：
Thomas Matula
金额：
$ 58.43万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-05 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9120875
关键词：
Abscess Acoustics Acute Aerobic Bacteria Affect AlamarBlue Anaerobic Bacteria Animal Model Antibiotic Therapy Antibiotics Autopsy Bacteria Biological Assay Body part Caring Catheter Management Catheters Characteristics Clinical Coagulative necrosis Control Groups Data Development Devices Disease Drainage procedure Drug resistance Escherichia coli Evolution Exposure to Focused Ultrasound Therapy Growth Health Health Care Costs Healthcare Heating Hospital Charges Hospitalization Human Image In Situ In Vitro Infection Injury Lead Length of Stay Liquid substance Location Measures Mechanics Modeling Monitor Morbidity - disease rate Muscle Operative Surgical Procedures Oryctolagus cuniculus Outpatients Pain Patients Physicians Pilot Projects Pus Radiation Resolution Risk Sampling Suspension substance Suspensions System Systemic infection Temperature Testing Therapeutic Thigh structure Time Tissues Training Trauma Treatment Efficacy Ultrasonic Therapy Ultrasonography Viscosity White Blood Cell Count procedure bactericide capsule compare effectiveness cost effective therapy image guided improved in vivo killings programs pus collection rectal research study screening standard of care treatment effect

项目摘要

DESCRIPTION (provided by applicant): Abscesses are infected walled-off fluid collections of pus and bacteria, and represent a ubiquitous global healthcare problem. They are common sequelae of surgery, infections or disease, and can affect any part of the body. Current standard of care includes hospitalization, antibiotics and drainage of the abscess with a catheter. The bacteria in puss are susceptible to both thermal and mechanical damage. High Intensity Focused Ultrasound (HIFU) can generate localized heating and cavitation, and is a potential noninvasive means to treat abscesses by exploiting one or both mechanisms. The significance of this proposal is that noninvasive treatment of reachable abscesses using ultrasound therapy under ultrasound guidance is better for the patient because it is noninvasive, allows treatment of small abscesses, has less procedural pain, requires no catheter management, there is no potential tract for new infections, and no need for CT/fluoro imaging radiation.

描述（由申请人提供）：脓肿是脓液和细菌的感染性液体聚集，代表了普遍存在的全球医疗保健问题。它们是手术、感染或疾病的常见后遗症，可以影响身体的任何部位。护理措施包括住院、使用抗生素和用导管引流脓肿。脓液中的细菌容易受到热损伤和机械损伤，高强度聚焦超声 (HIFU) 会产生局部发热和损伤。该提案的意义在于，在超声引导下使用超声治疗对可触及的脓肿进行无创治疗对患者来说更好，因为它是无创的，可以治疗小脓肿。脓肿，手术疼痛较少，不需要导管管理，没有新感染的潜在途径，并且不需要 CT/荧光成像辐射。