Strategic and Plasticity Interventions for Late Life Depression in Community Settings

社区环境中晚年抑郁症的战略和可塑性干预措施

基本信息

批准号：
8996065
负责人：
Patricia A. Arean
金额：
$ 17.33万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2017-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8996065
关键词：
Address Affect Anterior Antidepressive Agents Applications Grants Award Behavior Behavior Therapy Behavioral Biological Brain Brain region Clinical Clinical Trials Cognitive Color Complex Conflict (Psychology)Depressed mood Development Disease Dorsal Educational Curriculum Elderly Faculty Fertilization Functional Magnetic Resonance Imaging Funding Generations Goals Home environment Impaired cognition Intervention Intervention Studies Knowledge Learning Low income Measures Mental Depression Mental Health Mentors Mentorship Methods Mood Disorders Moods National Institute of Mental Health Nature Neurobiology Neuropsychology Observational Study Outcome Paper Participant Patients Pattern Performance Persons Postdoctoral Fellow Prefrontal Cortex Process Psychotherapy Recommendation Recruitment Activity Research Research Personnel Role Sampling Scanning Science Scientist System Thinking Time Training Visit Work World Health Organization Disability Assessment Schedule base behavioral neurology career cingulate cortex cognitive neuroscience community setting disability environmental change ethnic diversity executive function experience geriatric depression improved interest mild cognitive impairment next generation novel strategies problem solving therapy programs psychologic response skills theories treatment response

项目摘要

DESCRIPTION (provided by applicant): This is a competing renewal of a mid-career mentor award that was originally titled "Treating Depression in Low-Income Elderly with CIND/aMCI" and is now titled Strategic and Plasticity Interventions for Late Life Depression in Community Settings. The title change reflects the additional training I wish to pursue in the next five years of my career. In the original award, I studied neuropsychology and behavioral neurology associated with mild cognitive impairment. This experience allowed me to develop interventions that would address cognitive moderators of psychotherapy outcomes, and to mentor the next generation of psychotherapy researchers who are also interested in the intersection of cognitive impairments and the treatment of mood disorders in late life. That award resulted in 20 papers and 5 grant applications (4 were subsequently funded), the development of a mentoring program for junior faculty in my home department and personal mentorship of 9 junior faculty at UCSF, 3 faculty outside the UC system and 7 post doctoral fellows. In this proposal, I wish to study cognitive neuroscience of late life depression (LLD) and to learn more about plasticity interventions and their potential role in the treatment of LLD. My intent is not to change who I am as a researcher, but learn enough about these two vast fields so that I can (1) integrate what I learn from biological theory with the knowledge I already possess about psychological and sociological explanations of LLD, (2) work collaboratively with cognitive neuroscientists and plasticity interventionists to develop targeted behavioral interventions for LLD, and (3) add my expertise in the development of portable and geriatric friendly behavioral interventions to the field of plasticity intervention research. I believe this training will allow for better and mutual cross fertilization between the fields of psychotherapy and cognitive neuroscience, which will serve to improve mental health research directions. Because few scientists in our field have attempted to engage in this type of cross fertilization, I plan to also develop a training curriculum for post-doctoral fellows focused on the intersection of behavioral interventions research and cognitive neuroscience, to develop a generation of psychotherapy researchers who can work collaboratively with biologically oriented researchers in the treatment of late life mood disorders.

描述（由申请人提供）：这是职业生涯中期导师奖的竞争性更新，最初的标题是“用 CIND/aMCI 治疗低收入老年人的抑郁症”，现在的标题是社区晚年抑郁症的战略和可塑性干预措施设置。头衔的变更反映了我希望在未来五年的职业生涯中接受的额外培训。在最初的奖项中，我研究了与轻度认知障碍相关的神经心理学和行为神经学。这段经历使我能够开发出干预措施来解决心理治疗结果的认知调节因素，并指导下一代心理治疗研究人员，他们也对认知障碍和晚年情绪障碍的治疗感兴趣。该奖项产生了 20 篇论文和 5 份资助申请（其中 4 份随后获得资助），为我所在院系的初级教师制定了指导计划，并为加州大学旧金山分校的 9 名初级教师、加州大学系统外的 3 名教师和 7 名博士后提供个人指导各位。在本提案中，我希望研究晚年抑郁症 (LLD) 的认知神经科学，并了解更多有关可塑性干预措施及其在治疗 LLD 中的潜在作用。我的目的不是要改变我作为一名研究人员的身份，而是对这两个广阔的领域有足够的了解，以便我能够 (1) 将我从生物学理论中学到的知识与我已经掌握的关于 LLD 的心理学和社会学解释的知识相结合，( 2）与认知神经科学家和可塑性干预专家合作，开发针对 LLD 的有针对性的行为干预措施，以及（3）将我在开发便携式和老年人友好型行为干预措施方面的专业知识添加到可塑性干预研究领域。我相信本次培训将使心理治疗和认知神经科学领域之间更好地相互交叉，从而有助于完善心理健康研究方向。由于我们领域很少有科学家尝试进行这种类型的交叉受精，因此我还计划为博士后开发一门培训课程，重点关注行为干预研究和认知神经科学的交叉点，以培养一代心理治疗研究人员可以与生物学研究人员合作治疗晚年情绪障碍。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Use and Effectiveness of Mobile Apps for Depression: Results From a Fully Remote Clinical Trial.

移动应用程序治疗抑郁症的使用和有效性：完全远程临床试验的结果。

DOI：
发表时间：
2016-12-20
期刊：
影响因子：
7.4
作者：
Arean, Patricia A;Hallgren, Kevin A;Jordan, Joshua T;Gazzaley, Adam;Atkins, David C;Heagerty, Patrick J;Anguera, Joaquin A
通讯作者：
Anguera, Joaquin A

Does cognition predict treatment response and remission in psychotherapy for late-life depression?

认知是否可以预测晚年抑郁症心理治疗的治疗反应和缓解？