Comprhensive Center of Excellence in Health Disparities

健康差异综合卓越中心

• 批准号: 9013495
• 负责人: JOHN H. HOLMES
• 金额: $ 131.72万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-27 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9013495
• 关键词: Address; Affect; African; African American; American; Area; Behavioral; Biological; Biological Markers; Communities; Community Outreach; Consultations; Development; Development Plans; Diagnosis; Discipline; Ensure; Environment; Environmental Health; Environmental Risk Factor; European; Evaluation; Health Services Accessibility; Healthcare; Improve Access; Individual; Interdisciplinary Study; Intervention; Knowledge; Malignant neoplasm of prostate; Measures; Mission; Neighborhoods; Obesity; Outcome; Patterns of Care; Philadelphia; Populations at Risk; Postdoctoral Fellow; Research; Research Personnel; Research Project Grants; Resource Sharing; Risk; Risk Factors; Role; Training; Translational Research; Variant; cancer health disparity; cancer therapy; career development; contextual factors; data management; data modeling; disparity reduction; evidence base; experience; health disparity; interdisciplinary collaboration; men; model building; multilevel analysis; next generation; pre-doctoral; predictive modeling; programs; racial difference; response; social; success; summer program

This Center of Excellence (COE) is being submitted to address significant gaps in our knowledge about disparities prostate cancer (PCa) outcomes, and to develop interventions that can be applied to reduce these disparities between African (AA) and European (EA) Americans in Philadelphia. The mission of the proposed center is to (1) undertake research that will identify biological, behavioral, social, environmental, geospatial, physical environmental, and health care factors that influence PCa outcomes, and (2) integrate, evaluate, and disseminate this information to at-risk populations in Philadelphia communities. These factors include both individual and area-level contextual (e.g., neighborhood) variables. We anticipate that the principles of this approach will ultimately be implementable in other communities to reduce PCa disparities. This COE builds on our existing multidisciplinary research to specifically understand role of biomarkers, patterns of care, geospatial environment, and obesity after the diagnosis of PCa. This research requires transdisciplinary collaboration across multiple disciplines represented by the investigators participating in this COE. The proposed COE intends to catalyze needed improvements in the identification of men at greatest risk of unfavorable PCa outcomes to improve access to appropriate PCa treatment with the following Specific Aims: Aim 1: To conduct three highly interrelated transdisciplinary, translational research projects aimed at addressing prostate cancer disparities: a) Project 1: Evaluate the role of obesity in determining unfavorable prostate cancer outcomes (C. Zeigler-Johnson, PI); Project 2: Develop predictive models for understanding biomarkers, area-level contextual factors, and individual risk factors in predicting prostate cancer outcomes (T. Rebbeck, PI); Project 3: Determine whether variation in experienced and potential health care access and quality contributes to racial differences in treatment among men with localized prostate cancer (K. Armstrong, PI). Aim 2. To create specialized shared resource cores to serve the needs of these projects and the Center, including an Administrative Core (T. Rebbeck, Director); a research core (J. Holmes and C. Branas, co-Directors); and a community core (K. Glanz, Director). Aim 3: To develop transdisciplinary training at a variety of levels to train the next generation of health disparities researchers. Through this research, community outreach, and training, we will develop a program that can identify those groups at greatest risk for an unfavorable prostate cancer outcome, and develop approaches that can be used to minimize poor outcomes and the resulting disparities that unduly burden AA men.

该卓越中心 (COE) 的提交旨在解决我们对前列腺癌 (PCa) 结果差异的认识上的重大差距，并制定可用于减少非洲裔 (AA) 和欧洲 (EA) 美国人之间的这些差异的干预措施费城。拟建中心的使命是 (1) 开展研究，确定影响 PCa 结果的生物、行为、社会、环境、地理空间、物理环境和医疗保健因素，以及 (2) 整合、评估和传播这些信息费城社区的高危人群。这些因素包括个人和区域层面的背景（例如，邻里）变量。我们预计这种方法的原则最终将在其他社区实施，以减少 PCa 差异。 该 COE 建立在我们现有的多学科研究的基础上，专门了解 PCa 诊断后生物标志物、护理模式、地理空间环境和肥胖的作用。这项研究需要以参与该 COE 的研究人员为代表的跨多个学科的跨学科合作。拟议的 COE 旨在促进在识别 PCa 不良结果风险最大的男性方面进行必要的改进，以改善获得适当 PCa 治疗的机会，具体目标如下： 目标 1：开展三个高度相关的跨学科转化研究项目，旨在解决前列腺问题癌症差异：a) 项目 1：评估肥胖在确定不利的前列腺癌结果中的作用（C. Zeigler-Johnson，PI）；项目 2：开发预测模型，以了解预测前列腺癌结果的生物标志物、区域水平背景因素和个体风险因素（T. Rebbeck，PI）；项目 3：确定经验丰富和潜在的医疗保健获取和质量的差异是否会导致局限性前列腺癌男性治疗中的种族差异（K. Armstrong，PI）。目标 2. 创建专门的共享资源核心来满足这些项目和中心的需求，包括行政核心（T. Rebbeck，主任）；研究核心（联合主任 J. Holmes 和 C. Branas）；和社区核心（K. Glanz，总监）。目标 3：开展不同级别的跨学科培训，以培训下一代健康差异研究人员。通过这项研究、社区外展和培训，我们将制定一项计划，识别前列腺癌不良结果风险最大的群体，并开发可用于最大程度减少不良结果以及由此产生的给 AA 男性带来过度负担的差异的方法。

项目成果

Editorial: The Fruits of the Genomic Revolution.

社论：基因组革命的成果。

• 发表时间: 2018
• 作者: Rebbeck, Timothy R;Sellers, Thomas A
• 通讯作者: Sellers, Thomas A

Individual- and neighborhood-level education influences the effect of obesity on prostate cancer treatment failure after prostatectomy.

个人和社区教育影响肥胖对前列腺切除术后前列腺癌治疗失败的影响。

• 发表时间: 2015-09
• 作者: Zeigler;Morales, Knashawn H;Glanz, Karen;Spangler, Elaine;Mitchell, Jonathan;Rebbeck, Timothy R
• 通讯作者: Rebbeck, Timothy R

Performance of prostate cancer recurrence nomograms by obesity status: a retrospective analysis of a radical prostatectomy cohort.

按肥胖状态划分的前列腺癌复发列线图的表现：根治性前列腺切除术队列的回顾性分析。

• 发表时间: 2018-11-03
• 影响因子: 3.8
• 作者: Zeigler;Hudson, Aaron;Glanz, Karen;Spangler, Elaine;Morales, Knashawn H
• 通讯作者: Morales, Knashawn H