Determination of Research Needs and Specifications of The Research Beam Line and Related Infrastructure

确定研究需求和研究光束线及相关基础设施的规格

基本信息

批准号：
8811781
负责人：
Steve Bin Jiang
金额：
$ 16.46万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-10 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8811781
关键词：
Address Asia Attention Basic Science Cancer Patient Carbon ion Cell Nucleus Characteristics Charge Clinical Clinical Research Clinical Sciences Clinical Treatment Clinical Trials Communities Development Equipment Europe Facility Designs Funding Future Goals Heavy Ions Institution International Ions Medical Methods Mind Mission Modality Outcome Patients Peer Review Phase Phase III Clinical Trials Photons Physics Pilot Projects Preparation Principal Investigator Protons Radiation Radiation therapy Radiobiology Research Research Infrastructure Research Personnel Resources Running Solutions Specific qualifier value Staging Texas Therapeutic Therapeutic Studies Time Translational Research United States architectural drawings base cancer therapy design interest irradiation meetings particle particle therapy programs proton therapy research and development research study therapy design

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Choy, Hak Project Summary The United States currently does not offer to its cancer patients irradiation with ions heavier than protons. There are five facilities in Asia and two in Europe that currently treat patients with nuclei of carbon ions, many of them contributing to clinical trials to explore every advantage of heavy ion therapy. UT Southwestern created a three phase proposal to construct a tri-modality Texas Center for Advanced Radiation Therapy including a proton therapy (phase 1), a photon therapy (phase 2) and a heavier ion therapy (phase 3) facility. Phase 1 is already under construction, phase 2 is also funded and at a stage of architectural designing. Phase 3 is being planned. The goal of this pilot project is to identify the potential research questions associated with the use of charged particles in radio therapy and to determine the design parameters and specifications for the research beam line and related infrastructure to address these questions. We plan to achieve this goal via a rigorous, scientific, comprehensive and peer-reviewed approach as described with three specific aims: 1) Commission two task groups charged with developing a comprehensive analysis of the questions associated with the use of the charged particle therapy and with designing the specifications for the necessary components of beam line and infrastructure; 2) Determine the potential research scope of the National Particle Research Center; 3) Develop specifications related to the research beam-line, facility, and infrastructure PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

项目总监/首席研究员（最后、第一、中间）：Choy, Hak 项目概要美国目前不向癌症患者提供比质子重的离子照射。那里目前在亚洲有五个机构，在欧洲有两个机构正在治疗碳离子核患者，其中许多人为临床试验做出贡献，探索重离子疗法的每一个优点。 UT西南大学创造了三建设包括质子在内的三模式德克萨斯先进放射治疗中心的阶段提案疗法（第一阶段）、光子疗法（第二阶段）和重离子疗法（第三阶段）设施。第一阶段已经目前正在建设中，二期也已获得资金并处于建筑设计阶段。第三阶段正在规划中。该试点项目的目标是确定与使用带电材料相关的潜在研究问题放射治疗中的粒子并确定研究束线的设计参数和规格以及解决这些问题的相关基础设施。我们计划通过严格、科学、全面且经过同行评审的方法，具有三个具体目标：1）委托两项任务负责对与使用该工具相关的问题进行全面分析的小组带电粒子治疗以及设计束线和必要组件的规格基础设施; 2）确定国家粒子研究中心潜在的研究范围； 3）开发与研究光束线、设施和基础设施相关的规范 PHS 398/2590（修订版 06/09）页面延续格式页面