Controls in Animal Studies Professional Skills Course

动物研究控制专业技能课程

基本信息

批准号：
9146393
负责人：
Christina Noel Bennett
金额：
$ 2.64万
依托单位：
AMERICAN PHYSIOLOGICAL SOCIETY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-20 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9146393
关键词：
Address Affect Animal Care and Use Committees Animal Model Animals Applications Grants Biological Biomedical Research Chemicals Clinic Clinical Trials Community Practice Community of Practice Control Animal Digital Libraries Disease Education Educational process of instructing Educational workshop Ensure Environment Experimental Designs Fostering Funding Genetic Guidelines Health Human Institution International Intervention Journals Laboratories Laboratory Procedures Learning Learning Module Left Literature Manuscripts Methodology Methods Modeling Modification Organism Peer Review Play Postdoctoral Fellow Printing Professional Ethics Professional Organizations Publications Reporting Reproducibility Research Research Design Research Personnel Resources Role Staging Structure Students System Teaching Materials Techniques Testing Therapeutic Therapeutic Intervention Time Training Translating Trust United States National Institutes of Health Work Writing base career design drug candidate experimental analysis graduate student insight online community pedagogy research study skills skills training tool web site

项目摘要

DESCRIPTION (provided by applicant): Animal models are used in biomedical research studies to determine how genetic, therapeutic, and other modifications affect the structure and function of a living system. Some of these studies influence what drug candidates are selected for human clinical trials or what therapeutic intervention should be tested in the clinic. However, there is growing concern that much of the information reported in the scholarly literature, particularly those that use animal models, is unreliable due to poor experimental design and technique, improper analysis of findings or over- interpretation of results. As such, scholarly journals, funding bodies, and scientific associations have developed author, and reviewer, checklists to help ensure that the experimental details reported in manuscripts are accurate, robust and can be repeated by other investigators. Despite these efforts, by the time journals interact with researchers, as authors, the experimental portion of the study is complete including any flawed research practices related to the study. Thus, while journals can enforce transparency of the research reported in manuscripts, they cannot change how the original research was performed. To address this issue, we propose to develop an on-demand education module, for graduate students, postdoctoral fellows and early career investigators who use, or are planning to use animal models in their research. The module will be developed based upon our proven method for designing highly-effective Professional Skills Training (PST) Courses such as the writing and reviewing manuscripts PST and the publication ethics PST. In Aim 1 we will prepare an education module, focused on developing skills in designing, performing and reporting well- controlled animal studies, using effective student-centered learning pedagogy. In Aim 2, we will pilot, evaluate, and revise the draft module with multiple audiences including graduate students, postdoctoral fellows and other biomedical research investigators. In Aim 3, we will disseminate the revised version of the module and related teaching resources via free digital libraries, professional society workshops, and websites. In Aim 4, we will develop and support a community of practice for animal researchers in order to foster an ongoing dialogue on best practices for performing animal studies. The education materials and community of practice will provide biomedical researchers, who use animal models in their research, the resources they need in the lab to help them develop well designed, properly controlled research studies that are more likely to be accurate and reproducible.

描述（由申请人提供）：动物模型用于生物医学研究，以确定遗传、治疗和其他修饰如何影响生命系统的结构和功能，其中一些研究影响选择用于人类临床试验或的候选药物。然而，应该在临床上测试什么治疗干预措施。人们越来越担心学术文献中报道的许多信息，特别是那些使用动物模型的信息，由于实验设计和技术不佳、对结果的分析不当或对结果的过度解释而变得不可靠。机构和科学协会制定了作者和审稿人清单，以帮助确保手稿中报告的实验细节准确、可靠，并且可以由其他研究人员重复，尽管做出了这些努力，但当期刊与研究人员（作为作者）互动时，该研究的实验部分是因此，虽然期刊可以加强手稿中报告的研究的透明度，但它们不能改变原始研究的进行方式。为了解决这个问题，我们建议开发一个按需教育模块。，适用于在研究中使用或计划使用动物模型的研究生、博士后研究员和早期职业研究人员该模块将根据我们经过验证的设计高效专业技能培训 (PST) 课程的方法开发。撰写和审阅稿件 PST 和在目标 1 中，我们将准备一个教育模块，重点是使用以学生为中心的有效学习教学法来培养设计、执行和报告良好控制的动物研究的技能。在目标 2 中，我们将进行试点、评估和修订。目标3中，我们将通过免费数字图书馆、专业协会研讨会和网站传播该模块的修订版和相关教学资源。目标 4，我们将为动物研究人员建立和支持实践社区，以促进关于进行动物研究的最佳实践的持续对话。教育材料和实践社区将为在研究中使用动物模型的生物医学研究人员提供帮助。他们在实验室中需要的资源可以帮助他们开展设计良好、控制得当的研究，这些研究更有可能准确且可重复。