Colorado PETAL Clinical Center

科罗拉多州 PETAL 临床中心

基本信息

批准号：
9057600
负责人：
Adit A. Ginde
金额：
$ 37.39万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-17 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9057600
关键词：
Accident and Emergency department Acute Acute Lung Injury Address Admission activity Adult Respiratory Distress Syndrome Affect Alaska Native Ally American Indians Area Bilateral Caring Case Series Chest Clinical Clinical Research Clinical Trials Collaborations Colorado Conduct Clinical Trials Consent Country Critical Care Critical Illness Data Development Early treatment Emergency Medicine Emergency department visit Enrollment Extramural Activities Fostering Funding Goals Growth Health Hispanics Hospitals Hypoxemia Individual Injury Institutional Review Boards Intensive Care Units Intervention Lead Liquid substance Lung Manuscripts Mechanics Medical Medical center Medicine Methodology Methods Mosses Multi-Institutional Clinical Trial National Heart, Lung, and Blood Institute Operative Surgical Procedures Outcome Patient Care Patients Pneumonia Positioning Attribute Prevention Principal Investigator Process Protocol Compliance Protocols documentation Publications Publishing Pulmonary Embolism Recording of previous events Research Research Infrastructure Research Personnel Research Project Grants Residencies Resources Risk Rosa Sampling Science Seminal Sepsis Site Symptoms Syndrome Testing Time Training Programs Transfusion United States Universities Work base clinical care data acquisition experience improved improved outcome innovation medical specialties meetings member metropolitan patient oriented research prevent public health relevance research study screening

项目摘要

DESCRIPTION (provided by applicant): Almost 50 years ago, Dr. Tom Petty and his surgical colleagues identified 12 patients at the University of Colorado with similar clinical symptoms: severe hypoxemia, bilateral infiltrates on chest radiograph, and diminished static pulmonary compliance. The clinical features of these patients were published as a case series in the Lancet and serve as the initial description of the acute respiratory distress syndrome (ARDS). This seminal discovery launched a long and productive history of ARDS research in Denver. We have been a member of the ARDS Network since its inception in 1994. Our multi-disciplinary and collaborative critical care research group is experienced in conducting high quality multi-center clinical trials. As a result, we have always been one of the top enrolling ARDS Network sites for over 19 years. The University of Colorado's Department of Emergency Medicine was one of the first residency training programs in Emergency Medicine and remains one of most highly regarded training programs in the country. Their extramural funding has grown rapidly in the past decade especially in the area of critical care research. The Division of Pulmonary Sciences and Critical Care Medicine and the Department of Emergency Medicine have an established record of effective collaborations in both patient-oriented and research initiatives. Building on this ARDS Network research infrastructure, we will create an integrated Critical Care and Emergency Medicine clinical center to effectively conduct clinical trials for the prevention and early treatment of acute lung injury. This Colorado PETAL Clinical Center will exceed meet our enrollment obligations; maintain excellence in the quality of protocol compliance, data acquisition, and regulatory responsibilities; actively participate and contribute to the subsequent responsibilities of the steering and other PETAL committees; and contribute to the improved care of patients with and at risk for ARDS.

描述（由申请人提供）：大约 50 年前，Tom Petty 博士和他的外科同事在科罗拉多大学发现了 12 名具有相似临床症状的患者：严重低氧血症、胸片双侧浸润以及静态肺顺应性降低。这些患者的临床特征作为病例系列发表在《柳叶刀》上，并作为急性呼吸窘迫综合征（ARDS）的初步描述。这一开创性的发现开启了丹佛 ARDS 研究的悠久而富有成果的历史。自 1994 年 ARDS 网络成立以来，我们一直是该网络的成员。我们的多学科协作重症监护研究小组在开展高质量多中心临床试验方面经验丰富。因此，19 年来，我们一直是 ARDS Network 招生人数最多的网站之一。科罗拉多大学急诊医学系是最早的急诊医学住院医师培训项目之一，并且仍然是该国最受推崇的培训项目之一。他们的外部资金在过去十年中迅速增长，特别是在重症监护研究领域。肺科和重症监护医学科以及急诊医学科在以患者为中心的活动和研究活动方面都有有效的合作记录。在此ARDS网络研究基础设施的基础上，我们将创建一个综合的重症监护和急诊医学临床中心，以有效地开展预防和早期治疗急性肺损伤的临床试验。科罗拉多州 PETAL 临床中心将超出我们的注册义务；在协议合规性、数据采集和监管责任方面保持卓越的质量；积极参与并为后续工作做出贡献指导委员会和其他 PETAL 委员会的职责；并有助于改善对 ARDS 患者和面临 ARDS 风险的患者的护理。