Prevention of Lower Urinary Tract Symptoms in Women: Bladder Health Scientific and Data Coordinating Center (PLUS-SDCC) (U01)

预防女性下尿路症状：膀胱健康科学和数据协调中心 (PLUS-SDCC) (U01)

• 批准号: 9346861
• 负责人: John E Connett
• 金额: $ 30万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9346861
• 关键词: Accounting; Address; Adolescence; Affect; Age; Ancillary Study; Athletic; Behavior Therapy; Behavioral; Biological; Biological Factors; Biometry; Biostatistical Methods; Bladder; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Conceptual Domain; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Set; Databases; Development; Diagnosis; Disease; Education; Environment; Epidemiologic Studies; Epidemiology; Ethics; Future; Goals; Health; Health behavior; Incontinence; Infection; Inflammation; Intervention; Intervention Studies; Knowledge; Lead; Leadership; Longevity; Lower urinary tract; Meta-Analysis; Minnesota; Mission; Modeling; Monitor; Multi-Institutional Clinical Trial; Multicenter Studies; National Institute of Diabetes and Digestive and Kidney Diseases; Pain; Pelvic Infection; Pelvic Inflammatory Disease; Positioning Attribute; Prevention; Preventive Intervention; Process; Productivity; Publications; Quality of life; Questionnaires; Randomized Controlled Trials; Recording of previous events; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Review Literature; Risk; Risk Factors; Science; Series; Site; Social Interaction; Source; Specimen; Structure; Symptoms; Techniques; Testing; Translating; Treatment Efficacy; Universities; Woman; Women' s Health; Work; base; biopsychosocial; clinical care; data management; design; dissemination research; experience; flexibility; indexing; innovation; inter-institutional; lower urinary tract symptoms; meetings; member; modifiable risk; novel; population based; prevent; programs; psychological distress; repository; research study; skills; symposium

 DESCRIPTION (provided by applicant): Lower urinary tract symptoms (LUTS) in women are a source of illness, pain, and embarrassment, which can affect work, social interactions, and athletic and recreational activities in women from adolescence to old age. Almost 50% of women will experience LUTS at some point in their lifetime. Symptoms are harmful enough in themselves, but untreated, they can lead to more serious problems such as incontinence, infections, pelvic inflammation and psychological distress. The NIDDK program on Prevention of Lower Urinary tract Symptoms in women Research Consortium (PLUS-RC) is intended to broadly identify and evaluate the relative importance of the risk and protective factors for LUTS by conducting the necessary research studies to establish the scientific basis for future prevention intervention studies for lower urinary tract symptoms and conditions in women. Knowledge of such risk factors can lead to interventional strategies, which may be testable in future clinical trials. Specific aims of the PLUS-RC Scientific and Data Coordinating Center (SDCC) are to (1) conduct reviews of literature and meta-analyses of previous publications; (2) with the other PLUS-RC investigators, plan, design, and prioritize new epidemiologic and clinical studies of LUTS and implement an ancillary studies program; (3) provide data coordination and monitoring capabilities in support of PLUS-RC research studies; (4) provide comprehensive and innovative data analyses in support of presentation and publication of results, and construct high-quality datasets, which will be available to other researchers; and (5) provide logistical support for meetings and conference calls of the Steering and Planning Committee, all subcommittees, and an External Expert Panel for the efficient and ethical execution of consortium objectives. We bring together a uniquely strong team with a long history of accomplishment in biostatistics, epidemiology, and the conduct of large multi-center studies, extensive expertise in meta-analysis, observational data analysis, epidemiology specifically related to women's health, skills in behavioral modification and prevention science, and clinical care experience in the diagnosis and treatment of LUTS in women.

 描述（由申请人提供）：女性下尿路症状 (LUTS) 是疾病、疼痛和尴尬的根源，会影响从青春期到老年的女性的工作、社交以及运动和娱乐活动。 % 的女性在一生中的某个阶段会经历 LUTS，这些症状本身就很有害，但如果不加以治疗，可能会导致更严重的问题，如失禁、感染、盆腔炎症和心理困扰。 NIDDK 预防女性下尿路症状研究联盟 (PLUS-RC) 旨在通过开展必要的研究，广泛识别和评估 LUTS 风险和保护因素的相对重要性，为未来奠定科学基础。对女性下尿路症状和状况的预防干预研究可以制定干预策略，这些策略可以在未来的临床试验中进行测试。中心 (SDCC) 将 (1) 对先前出版物进行文献综述和荟萃分析；(2) 与其他 PLUS-RC 研究人员一起计划、设计和优先考虑 LUTS 的新流行病学和临床研究，并实施辅助研究(3) 提供数据协调和监测能力，以支持 PLUS-RC 研究； (4) 提供全面和创新的数据分析，以支持结果的呈现和发布，并构建高质量的数据集，供其他研究人员使用。 ; (5) 为指导和规划委员会、所有小组委员会以及外部专家小组的会议和电话会议提供后勤支持，以高效、合乎道德地执行联盟目标。我们汇集了一支拥有悠久成就的独特强大团队。拥有生物统计学、流行病学和开展大型多中心研究方面的专业知识，在荟萃分析、观察数据分析、与妇女健康特别相关的流行病学方面拥有丰富的专业知识，行为矫正和预防科学方面的技能，以及临床护理经验女性 LUTS 的诊断和治疗。