Flow Cytometry Shared Service

流式细胞术共享服务

基本信息

批准号：
9145399
负责人：
Xiaoxuan Fan
金额：
$ 12.55万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-04 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9145399
关键词：
Americas Area Baltimore Basic Science Biomedical Research Biometry Blood Cancer Biology Cancer Center Cancer Center Support Grant Cell Separation Cells Cigarette Clinical Research Clinical Sciences Communication Communities Computer software Consultations County Data Analyses Doctor of Medicine Education Equipment Flow Cytometry Fluorescence Funding Genomics Grant Guidelines Hormone Responsive Human Image Institutes Investigational Therapies Journals Laboratories Malignant Neoplasms Maryland Medical Medical center Methodology Mission Molecular Biology Nature Pathology Peer Review Pharmacy Schools Population Sciences Public Health Schools Publications Research Research Personnel Resources Retroviridae Sampling School Dentistry Science Services Sorting - Cell Movement Speed Sterility Subfamily lentivirinae System Technical Expertise Technology Training United States National Academy of Sciences United States National Institutes of Health Universities abstracting acronyms base biobank clinical investigation college design instrument instrumentation medical schools member neoplasm immunotherapy nonhuman primate novel pre-clinical programs ranpirnase structural biology training opportunity tumor immunology virology

项目摘要

5.0 Abstract: Flow Cytometry Shared Service The mission of the Flow Cytometry Shared Service (FCSS) is to offer state-of-the-art instrumentation and technical expertise to UMGCC members to assist in the conduct of cancer biology research. The facility provides full-scale, state-of-the-art flow cytometry services including sample acquisition, data analysis, fluorescent cell sorting, experimental planning, and pre- and postexperimental consultation in support of NCI- sponsored research. The FCSS also assists investigators in the flow cytometry components of pilot grants supported by the NCI P30 funding and provides training on analytical instrumentation to users. The user training is designed to permit investigators to independently acquire samples and perform data analysis. The FCSS is committed to the dissemination of novel flow cytometry–based technologies through continuous education of UMGCC investigators. The FCSS has proved to be a key supporter of UMGCC and has supported over 50 UMGCC labs (out of more than 70 labs), leading to more than 90 peer-reviewed publications in the past 5 years. The FCSS has facilitated a wide range of basic science studies and has also had an important impact on clinical research efforts. In 2014, the FCSS supported 66 Cancer Center members spanning all 5 research programs (26 percent of all UMGCC members), with 42 of them (64 percent of UMGCC users) having peer-reviewed funding. The FCSS supports many cancer-related publications annually, with several in high-impact journals including Nature Communications, Journal of Clinical Investigation, Proceedings of the National Academy of Sciences of the United States of America, and Blood.

5.0 摘要：流式细胞术共享服务流式细胞术共享服务 (FCSS) 的使命是提供最先进的仪器和向 UMGCC 成员提供技术专业知识，以协助该设施进行癌症生物学研究。提供全面、最先进的流式细胞术服务，包括样品采集、数据分析、荧光细胞分选、实验计划以及实验前和实验后咨询，以支持 NCI- FCSS 还协助研究人员进行试点资助的流式细胞术部分。由 NCI P30 资金支持，并向用户提供分析仪器培训。培训旨在允许研究人员独立采集样本并进行数据分析。 FCSS 致力于通过持续不断地传播基于流式细胞术的新型技术事实证明，FCSS 是 UMGCC 的重要支持者，并已支持 50 多个 UMGCC 实验室（超过 70 个实验室），从而产生了 90 多个同行评审的实验室过去 5 年中，FCSS 促进了广泛的基础科学研究。对临床研究工作产生了重要影响。 2014 年，FCSS 支持 66 名癌症中心成员，涵盖所有 5 个研究项目（占所有研究项目的 26%） UMGCC 成员），其中 42 个（占 UMGCC 用户的 64%）拥有经过同行评审的资金。每年支持许多与癌症相关的出版物，其中一些发表在包括《自然》在内的高影响力期刊上通讯，临床研究杂志，美国国家科学院院刊美利坚合众国和血液。