Mindfulness and Mechanisms of Pain Processing in Adults with Migraines

成人偏头痛患者的正念和疼痛处理机制

• 批准号: 9115533
• 负责人: Rebecca Erwin Wells
• 金额: $ 13.43万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9115533
• 关键词: Address; Adult; Advisory Committees; Affect; Affective; American; Awareness; Brain region; Chronic; Clinical; Clinical Research; Clinical Trials; Cognitive; Complementary Medicine; Control Groups; Cross-Sectional Studies; Data; Dimensions; Discipline; Education; Emotional; Event; Frequencies; Goals; Grant; Headache; Health; Healthcare; Heating; Integrative Medicine; K-Series Research Career Programs; Knowledge; Manuscripts; Measures; Meditation; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Migraine; Mind-Body Intervention; Mission; Modeling; Neurobiology; Outcome; Pain; Pain Measurement; Pain intensity; Pain management; Patients; Pharmaceutical Preparations; Play; Population; Process; Productivity; Randomized Clinical Trials; Reporting; Research; Research Personnel; Research Training; Role; Safety; Sensory; Skills Development; Stress; Techniques; Testing; Time; Training; Writing; Yoga; career; career development; clinical efficacy; cognitive process; cohort; cost; cost efficient; design; disability; evidence base; improved; mindfulness; mindfulness meditation; mindfulness-based stress reduction; multidisciplinary; pilot trial; predicting response; prevent; response; responsible research conduct; sensory mechanism; skill acquisition; skills; skills training; statistics; symposium

 DESCRIPTION (provided by applicant): The goal of the proposed K23 award is to provide the Candidate with the advanced skills and training needed to become an independent investigator evaluating the mechanisms of migraine pain and the efficacy and mechanisms of mind-body interventions for treatment. To facilitate this long-term career goal, the Candidate will examine the sensory and affective responses to experimental pain in migraineurs compared to healthy controls. In addition, the Candidate will assess the impact and mechanisms of an 8-week standardized mind-body intervention, Mindfulness-Based Stress Reduction (MBSR), on the sensory and affective aspects of clinical and experimental pain in adults with migraines, and determine predictors of clinical efficacy. The Candidate has assembled an expert team of mentors to help her achieve these goals. A comprehensive training plan includes important additional training needed in the neurobiology of pain, state-of-the-art methodologies of the quantitative assessment of pain, statistics, formal coursework, and conferences and seminars addressing grant and manuscript writing, as well as other relevant career development topics. The Candidate has assembled a stellar, multidisciplinary mentorship and advisory team tailored to facilitate her research and training with their combined expertise in pain mechanisms, sensory/pain testing, headache, statistics, mind-body medicine, clinical research, and career development. With their support, she will accomplish the following specific training goals: (1) gain advanced training and knowledge in the neurobiology of pain and headache; (2) develop expertise in the quantitative measurements of pain; (3) expand mind-body medicine knowledge and training skills; (4) improve skills in clinical trial methodology and responsible conduct of research; (5) build on statistical skills with further skill training; (6) continue building profesional development skills. The training plan will be conducted in coordination with a proposed set of studies that build upon the Candidate's preliminary data that demonstrated a beneficial effect of MBSR in adults with migraines. The Candidate's proposed research involves three Specific Aims. Aim 1 is designed to assess response to experimental heat pain (pain intensity, pain unpleasantness, emotional reactivity, and pain catastrophizing) in migraineurs (interictally) vs. healthy controls. Aim 2 seeks to test the impact of MBSR in adults with migraines on clinical headache pain, experimental heat pain, mindfulness, pain acceptance, pain catastrophizing, emotional reactivity and headache-related disability compared to an education control group. Aim 3 is to determine the factors that predict MBSR response on clinical headache pain in migraine patients. Successful completion of these aims will advance the understanding of the mechanisms of migraine pain and of mind- body interventions for migraine, and also may be applicable to other clinical pain conditions. The additional training from this K23 will launch the Candidate's career as an independent clinician-investigator and ultimately a leader in the fields of integrative medicine and headache research.

 描述（由申请人提供）：拟议的 K23 奖项的目标是为候选人提供成为独立研究者所需的高级技能和培训，以评估偏头痛的机制以及身心干预治疗的功效和机制。为了实现这一长期职业目标，候选人将检查偏头痛患者与健康对照者对实验性疼痛的感觉和情感反应。此外，候选人还将评估为期 8 周的标准化的影响和机制。身心干预，基于正念的减压（MBSR），针对成人偏头痛的临床和实验疼痛的感觉和情感方面，并确定临床疗效的预测因素。候选人组建了一个导师专家团队来帮助她实现这一目标。这些目标包括疼痛神经生物学、最先进的疼痛定量评估方法、统计学、正式课程以及涉及资助和手稿写作的会议和研讨会。候选人组建了一支一流的多学科指导和咨询团队，利用他们在疼痛机制、感觉/疼痛测试、头痛、统计学、身心医学、临床方面的综合专业知识，促进她的研究和培训。在他们的支持下，她将实现以下具体培训目标：（1）获得疼痛和头痛神经生物学方面的高级培训和知识；（2）发展疼痛定量测量方面的专业知识；扩展身心医学知识和培训技能； (4) 提高临床试验方法和负责任的研究开展方面的技能； (5) 通过进一步的技能培训加强统计技能； (6) 继续培养专业发展技能。该研究以候选人的初步数据为基础，该数据证明了 MBSR 对成人偏头痛患者的有益作用。候选人提出的研究涉及三个具体目标，目标 1 旨在评估对实验性热痛的反应（疼痛强度、疼痛不愉快、情绪）。目标 2 旨在测试偏头痛成人患者的 MBSR 对临床头痛、实验性热痛、正念、疼痛接受、疼痛灾难性、情绪反应性和头痛的影响。目标 3 是确定预测偏头痛患者临床头痛疼痛的 MBSR 反应的因素。偏头痛的机制和偏头痛的身心干预，也可能适用于其他临床疼痛状况。本 K23 的额外培训将启动 候选人作为独立临床医生研究员的职业生涯，最终成为综合医学和头痛研究领域的领导者。