Beyond textbook, yet simple, statistical tools for reproducible animal research

超越教科书的简单统计工具，用于可重复的动物研究

基本信息

批准号：
9142329
负责人：
DAVID B ALLISON
金额：
$ 6.91万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-10 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9142329
关键词：
Address Advocate American Animal Experimentation Animals Basic Science Biometry Characteristics Collaborations Communication Communities Complex Consult Country Crossover Design Data Education Educational Materials Educational process of instructing Equation Evaluation Experimental Designs Face Failure Fostering Health Human Human Resources Immersion Investigative Technique Intervention Investigation Knowledge Laboratories Laboratory Animals Laboratory Research Laboratory Scientists Learning Measures Methods Mission Modeling National Institute of General Medical Sciences Natural Sciences Paper Postdoctoral Fellow Procedures Protocols documentation Publishing Randomized Reading Recommendation Reproducibility Research Research Design Research Misconduct Research Personnel Resources Science Scientist Self Assessment Statistical Data Interpretation Testing Textbooks Training Training Activity Translating Uncertainty United States National Institutes of Health Woman Writing career cost design experience experimental analysis graduate student help-seeking behavior improved innovation laboratory experience learning materials men next generation research study statistics tool web portal web site

项目摘要

DESCRIPTION (provided by applicant): The capacity of laboratory animal research to be translated to interventions for human health is dependent on research reproducibility, replicability, and generalizability (RRG). It is often the case that challenges with RRG arise from differences in scientific protocols, unknown or uncontrolled confounding factors, incomplete communication of scientific protocols, and unintentional misapplication of statistical principles, rather than the oft-discussed research misconduct. Many of these challenges with RRG involve practical and theoretical aspects of statistics and study design that go beyond what is taught in basic statistics courses or textbooks. We therefore propose creating a set of animated vignettes to educate early career, laboratory animal investigators (namely, graduate students, postdoctoral fellows, and beginning investigators) about these issues. We specifically propose modules on variability, power, randomization, hypothesis testing, and inferences that address common, and yet not routine-textbook needs of laboratory researchers. Each module will be composed of several short, animated vignettes that will 1) discuss a statistical or design principle that is important for RRG; 2) foster dialogue and collaboration between statistical and laboratory animal scientists; and 3) model diversity of statistical and laboratory animal scientist with respect to expertise and demographic characteristics. Each vignette will also be evaluated for content validity, face validity, and educational value by consulting with statistical experts, experienced lab animal researchers, and early career investigators, respectively. Finally, vignettes will be reinforced with additional online instructional content, including tutorial literture and self-assessment quizzes. Our team will widely disseminate the instructional materials leveraging our experience and resources creating and sharing online educational content, and we commit to maintain the materials in an openly available web portal without cost to end users. By supporting principles of RRG in this way, we contribute broadly to the mission of the NIH in fostering fundamental creative discoveries, innovative research strategies, and their applications; developing, maintaining, and renewing scientific human resources; and exemplifying and promoting the highest level of scientific integrity in the conduct of science. We specifically contribute to the mission of the NIGMS by "training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacities throughout the country."

描述（由申请人提供）：实验动物研究转化为人类健康干预措施的能力取决于研究的可重复性、可复制性和普遍性（RRG）。RRG 的挑战通常来自于。科学方案的差异、未知或不受控制的混杂因素、科学方案的不完整沟通以及统计原理的无意误用，而不是经常讨论的研究不当行为，RRG 面临的许多挑战涉及统计和研究设计的实践和理论方面。因此，我们建议制作一组动画短片，以教育早期职业实验动物研究人员（即研究生、博士后研究员和初级研究人员）了解这些问题。特别提出了有关变异性、功效、随机化、假设检验和推论的模块，这些模块可满足实验室研究人员的常见但非常规教科书需求。每个模块将由几个简短的动画小插图组成，这些小插图将 1) 讨论统计或设计。对 RRG 很重要的原则；2）促进统计和实验动物科学家之间的对话和合作；3）统计和实验动物科学家在专业知识和人口特征方面的模型多样性也将得到评估。有效性和教育价值最后，我们将通过额外的在线教学内容（包括教程文献和自我评估测验）来强化小插曲，并利用我们的经验广泛传播教学材料。以及创建和共享在线教育内容的资源，我们致力于在开放的门户网站中维护这些材料，而无需最终用户支付任何费用。通过以这种方式支持 RRG 的原则，我们为 NIH 促进基础教育的使命做出了广泛贡献。创造性发现、创新研究策略及其应用；开发、维护和更新科学人力资源；并具体体现和促进科学行为中的最高水平的科学诚信。下一代科学家，增强科学队伍的多样性，并发展全国各地的研究能力。”