Wearable Biosensors for Real-time Blood Alcohol Monitoring

用于实时血液酒精监测的可穿戴生物传感器

• 批准号: 9049223
• 负责人: ROBERT M ANTHENELLI
• 金额: $ 18.19万
• 依托单位: BIOLINQ INCORPORATED
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-10 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9049223
• 关键词: 3-Dimensional; Address; Adolescent; Adoption; Adult; Affect; Age; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Archives; Biological Assay; Biosensor; Blood; Blood alcohol level measurement; Blood specimen; Breath Tests; Cessation of life; Clinical; Data; Deposition; Detection; Development; Devices; Diagnosis; Dimensions; Disease; Disease Management; Economic Burden; Economics; Electrochemistry; Electrodes; Ensure; Enzymes; Ethanol; Evaluation; Exhibits; Gold; Health Personnel; Hour; Human; Individual; Injection of therapeutic agent; Injury; Intercellular Fluid; Lead; Life; Liver Cirrhosis; Malignant Neoplasms; Measurement; Measures; Mental Health; Methods; Microelectrodes; Molds; Monitor; Nature; Outcome; Outcomes Research; Pain-Free; Performance; Phase; Physiological; Polymers; Population; Prevalence; Price; Printing; Reading; Recruitment Activity; Regimen; Relapse; Reporting; Research; Research Infrastructure; Research Project Grants; Resolution; Risk Factors; Sampling; Skin; Solutions; Staging; Stratum corneum; Surface; System; Techniques; Therapeutic; Time; Transducers; Treatment Protocols; United States; Validation; Venipunctures; Vertebral column; Wireless Technology; alcohol measurement; alcohol misuse; alcohol monitoring; alcohol oxidase; alcohol use disorder; base; cost; cost effective; design; disability; improved; innovation; insight; interstitial; meetings; miniaturize; novel; premature; programs; public health relevance; response; screening; sensor; social stigma; statistics; success; transmission process; trend; volunteer

 DESCRIPTION (provided by applicant): Alcohol consumption has universal prevalence and widespread socio-cultural reach. The addictive nature of alcohol has resulted in the compulsive and uncontrolled consumption of alcoholic beverages for a sizeable segment of the global population. Overconsumption of alcohol is associated with a plethora of physiological and mental health consequences, some of which include alcohol dependence, liver cirrhosis, cancers, and bodily injury from operating machinery while intoxicated [1]. Not surprisingly, alcohol misuse is the fifth leading risk factor for premature death and disability, however, astonishingly, among people between the ages of 15 and 49, it is the first [2]. In the United States alone, alcohol misuse resulted in nearly 88,000 fatalities in 2006 [3] and was responsible for an economic burden of over $200 billion [4]. A recent study reported in 2012 concluded that 7.2 percent of the adult population in the US was affected by an alcohol use disorder (AUD) [5], further substantiating the widespread prevalence of this disease. In spite of these statistics, most of the human and economic tolls of alcoholism are preventable through various programs aimed at identifying the instigators of overconsumption [3]. This project aims to address the above challenges associated with the management of AUD via the development of an alcohol-selective microneedle array biosensor, applied to the skin as a concealed transdermal patch. The proposed wearable device leverages our team's latest innovations in electrochemistry, micro-manufacturing, conducting polymers, surface functionalization, and wireless microelectronics to tender the real-time profile of circulating alcohol levels in the interstitial luid in a non-invasive, pain-free fashion, thereby leading to substantially improved compliance over existing alcohol monitoring solutions. Expected outcomes from this research project include: (1) the development of unobtrusive, low-cost microneedle-based biosensors containing an embedded alcohol-selective layer; (2) the pairing of said alcohol biosensors with an onboard electrochemical analyzer and low-power wireless transmission capabilities facilitating the presentation of results to the operator and archiving for compliance purposes; and (3) validation of the microneedle-based alcohol quantification method in the clinical setting. This approach agglomerates innovative techniques for the functionalization of the microneedle-based electrode contingent and relies on the development of biocatalytic transducers in connection with novel methods of electrochemical transduction. The salient features of this transdermal biosensor platform include high sensitivity, stability, selectivity, simplicity, versatility, and robustness t a price that is amenable to widespread adoption. By evaluating the platform in the clinical setting, the insight gathered from this study could lead towards the development of a wearable platform capable of identifying the instigators of overconsumption, monitoring trends, and assessing compliance with prescribed treatment regimens, hence ensuring improved outcomes and management of the disease.

 描述（由申请人提供）：酒精消费具有普遍性和广泛的社会文化影响，酒精的成瘾性导致全球相当一部分人口强迫性和不受控制地消费酒精饮料。大量的生理和心理健康后果，其中包括酒精依赖、肝硬化、癌症以及醉酒操作机器造成的身体伤害[1]，毫不奇怪，滥用酒精是第五大风险。然而，令人惊讶的是，在 15 岁至 49 岁之间的人群中，酗酒是导致过早死亡和残疾的首要因素 [2]，仅在美国，2006 年，滥用酒精就导致了近 88,000 人死亡 [3]，并且是造成这一因素的原因。超过 2000 亿美元的经济负担 [4] 2012 年的一项最新研究得出结论，美国 7.2% 的成年人受到酒精使用障碍 (AUD) 的影响。 [5]，进一步证实了这种疾病的广泛流行，尽管有这些统计数据，但通过旨在确定过度消费的煽动者的各种计划，大多数酗酒造成的人员和经济损失是可以预防的[3]。通过开发酒精选择性微针阵列生物传感器，将其作为隐藏式透皮贴片应用于皮肤，可以解决上述与 AUD 管理相关的挑战。所提出的可穿戴设备利用了我们团队在以下方面的最新创新。电化学、微制造、导电聚合物、表面功能化和无线微电子技术，以无创、无痛的方式实时提供间质液中循环酒精水平的情况，从而大大提高现有酒精的依从性该研究项目的预期成果包括：(1) 开发包含嵌入式酒精选择性层的不显眼、低成本的微针生物传感器；(2) 配对技术。具有机载电化学分析仪和低功率无线传输功能的所述酒精生物传感器有助于向操作者呈现结果并出于合规性目的进行存档；以及（3）在临床环境中验证基于微针的酒精定量方法。聚集了基于微针的电极组功能化的创新技术，并依赖于与电化学转导新方法相关的生物催化传感器的开发。生物传感器平台具有高灵敏度、稳定性、选择性、简单性、多功能性和稳健性，价格适合广泛采用。通过在临床环境中评估该平台，从本研究中收集到的见解可能有助于开发可穿戴平台。确定过度消费的煽动者、监测趋势并评估对规定治疗方案的遵守情况，从而确保改善结果和疾病管理。