Drug Abuse Treatment Development and Research Mentoring

药物滥用治疗开发和研究指导

• 批准号: 8842609
• 负责人: Edward V. Nunes
• 金额: $ 17.05万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8842609
• 关键词: Abstinence; Address; Adopted; Alcohol or Other Drugs use; Area; Audiotape; Award; Behavior Therapy; Brain imaging; Buprenorphine; Carbidopa; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Clonidine; Cocaine; Cocaine Abuse; Cocaine Dependence; Collaborations; Communities; Community Networks; Computers; Corpus striatum structure; Criminal Justice; Development; Development Plans; Dopamine; Dronabinol; Drug Metabolic Detoxication; Drug Use Disorder; Drug abuse; Effectiveness; Faculty; Failure; Fostering; Functional Magnetic Resonance Imaging; Funding; Goals; Hospitalization; Incentives; Individual; Injection of therapeutic agent; Inpatients; Intervention; Knowledge; Language; Lead; Leadership; Levodopa; Life; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Naltrexone; National Institute of Drug Abuse; New York; Online Systems; Opiate Addiction; Oral; Outcome; Outpatients; Parkinsonian Disorders; Patient Self-Report; Patients; Pharmaceutical Preparations; Phase; Physicians; Positron-Emission Tomography; Postdoctoral Fellow; Procedures; Psychologist; Public Health; Raclopride; Recording of previous events; Recruitment Activity; Relapse; Research; Research Design; Research Personnel; Site; Statistical Methods; Statistical Study; Subgroup; Substance Use Disorder; Supervision; System; TNFRSF5 gene; Technology; Teleconferences; Testing; Therapeutic; Time; Training; Urine; Work; addiction; base; career; career development; clinical research site; community based care; community based practice; community based treatment; cost; disorder later incidence prevention; effective therapy; effectiveness research; effectiveness trial; efficacy testing; entacapone; improved; indexing; innovation; interactive therapy; interest; motivational enhancement therapy; next generation; novel strategies; patient oriented; patient oriented research; presynaptic; programs; protocol development; research and development; skills; symposium; therapy development; tool; transmission process; treatment as usual; treatment program

DESCRIPTION (provided by applicant): The goal of this K24 competing renewal is to allow the Candidate, Dr. Edward Nunes, to continue to devote near full time effort to his program of research on drug abuse treatment and mentorship of aspiring clinician-investigators. Dr. Nunes' overarching goals are to develop and test new treatment interventions that have the potential to significantly improve the outcome of drug use disorders, advancing them across the spectrum from efficacy to effectiveness, and to help train and foster the next generation of clinician-researchers in the field of addictions treatment. His strategy is to seek out new innovations and develop them through clinical trials, putting together teams with the relevant expertise, and always including one or more young investigators whose career he is helping develop. The Research Plan for the new funding period will focus on: 1) Testing medications for cocaine dependence, focusing on the subgroup that fails to rapidly respond to behavioral therapy; 2) Improving the effectiveness and differential therapeutics of injection naltrexone for the treatment of opioid dependence; 3) Testing the effectiveness of an interactive web-based behavioral therapy for the treatment of substance use disorders in community-based treatment programs; and 4) Further developing and testing a method for training community-based clinicians in Motivational Interviewing. During the course of the award, Dr. Nunes will serve as PI on two R01s, PI of a Node in the NIDA-funded National Drug Abuse Clinical Trials Network, and Co-Investigator-Sponsor of a Center project, Co-I on several other R01s with junior and mid-career colleagues, and primary Mentor on two K23 awards. The Career Development Plan will expand Dr. Nunes' knowledge in the areas of statistical methods and study design, and through synergistic collaborations with other investigators in areas such as brain imaging as a tool for treatment development, and technology-based treatments. Dr. Nunes' mentoring plan focuses on clinician-investigators, particularly physicians and clinical psychologists at the post-doctoral and junior faculty level. This group is important to the field, but has been a challenge to attract and retain in research careers. This research and mentoring plan has important public health significance. Substance use disorders are a major public health problem, and remain difficult to treat. Effective new treatments have been developed, but rates of failure and relapse with each of the major substance use disorders remains high, and innovative new treatment approaches are needed. Even effective treatments often fail to be adopted in community-based practice, and effectiveness research is needed to bridge this gap. Also of great public health concern is a dearth of adequately trained physician-investigators interested in careers in addictions research. Through Dr. Nunes' activities, it is hoped that the treatment of substance use disorders will improve through his research and collaborations, and his training of the next generation of clinician-investigators.

描述（由申请人提供）：本次 K24 竞争更新的目标是让候选人 Edward Nunes 博士继续投入近乎全职的精力来从事药物滥用治疗的研究项目以及对有抱负的临床医生研究人员的指导。努内斯博士的首要目标是开发和测试新的治疗干预措施，这些干预措施有可能显着改善吸毒障碍的结果，从功效到有效性全面推进它们，并帮助培训和培养下一代临床医生。成瘾治疗领域的研究人员。他的策略是寻找新的创新并通过临床试验来开发它们，组建具有相关专业知识的团队，并始终包括一名或多名他正在帮助发展职业生涯的年轻研究人员。 新资助期的研究计划将重点关注：1）测试可卡因依赖药物，重点关注无法对行为疗法快速做出反应的亚组； 2）提高注射纳曲酮治疗的有效性和差异化治疗 阿片类药物依赖； 3) 测试基于网络的交互式行为疗法在社区治疗项目中治疗物质使用障碍的有效性； 4) 进一步开发和测试一种培训社区临床医生动机访谈的方法。在获奖期间，Nunes 博士将担任两项 R01 的 PI、NIDA 资助的国家药物滥用临床试验网络节点的 PI、中心项目的联合研究员兼发起人、多个项目的 Co-I其他 R01 与初级和中期职业同事以及两个 K23 奖项的主要导师。职业发展计划将扩展努内斯博士在统计方法和研究设计领域的知识，并通过与其他研究人员在脑成像作为治疗开发工具和基于技术的治疗等领域的协同合作。 Nunes 博士的指导计划重点关注临床医生研究人员，特别是博士后的医生和临床心理学家 和初级教师水平。这个群体对该领域很重要，但吸引它一直是一个挑战 并保留在研究生涯中。 这项研究和指导计划具有重要的公共卫生意义。药物滥用障碍是一个重大的公共卫生问题，并且仍然难以治疗。有效的新疗法已经被开发出来，但每种主要物质使用障碍的失败率和复发率仍然很高，需要创新的新治疗方法。即使有效的治疗方法也常常无法在社区实践中得到采用，因此需要进行有效性研究来弥补这一差距。同样令人担忧的公共卫生问题是缺乏训练有素、对成瘾研究感兴趣的医生兼调查员。通过努内斯博士的活动，希望通过他的研究和合作以及对下一代临床研究人员的培训，药物滥用障碍的治疗将得到改善。