Partnership-3: multimode quantitative ultrasound prototype breast scanner

Partnership-3：多模式定量超声原型乳腺扫描仪

基本信息

批准号：
8907915
负责人：
JAMES W WISKIN
金额：
$ 70.96万
依托单位：
QT IMAGING, INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-26 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8907915
关键词：
3-Dimensional Acoustics Agar Algorithms Back Benign Biopsy Breast Breast Cancer Detection Cadaver California Characteristics Chest wall structure Clinical Trials Complement Computer software Coupled Data Data Collection Development Diagnostic Imaging Differential Equation Dimensions Electronics Elements Equation Funding Goals Grant Guidelines Head Health Human Image Incidence Length Malignant - descriptor Malignant Neoplasms Mammary Gland Parenchyma Mammography Measurement Methods Morphologic artifacts Motion Noise Patients Penetration Performance Polymers Positioning Attribute Property Relative (related person)Research Resolution Sampling Scanning Schedule Signal Transduction Slice Speed System Technology Testing Time Tissues Training Transducers Ultrasonography Universities Urethane Work accurate diagnosis advanced simulation attenuation base breast cancer diagnosis breast scanner data acquisition design imaging software imaging system improved operation preclinical study programs prototype quantitative imaging quantitative ultrasound simulation sound tissue phantom tomography transmission process volunteer

项目摘要

DESCRIPTION (provided by applicant): This Academic-Industrial partnership grant program is focused on the development of a new ultrasound tomography system (designated as the Partnership scanner) for breast cancer detection. Steven A. Johnson at TechniScan, Inc. will be the coordinating PI. This scanner is designed to extend and improve on features of TechniScan's previous breast ultrasound tomographic scanning system (USCT scanner). The scanner provides Inverse Scattering Tomography (IST) quantitative imaging of sound speed and acoustic attenuation. IST images are currently made from 180 forward directed scattering measurements on a receiver that moves in 2 degree steps around 360 degrees. It also moves in 1 mm vertical steps to scan three dimensions. The IST spatial resolution is about 1.5 mm horizontally and 2 mm vertically. New algorithms will be developed and upgraded hardware will be constructed during the first two and half years of the 5 year grant period. The new Partnership scanner will increase the number of inverse scattering receiver transducers from 1536 to 3072 and the number of receiver rows from 8 to 16. The number of IST transmitter rows will be increased from 8 to16 to allow for vertical beam steering. This program will improve existing IST and Reflection Tomography (RT) algorithms over its 5 year funding period. The speed for improved calculation will be provided by four or more NVIDIA graphic processor units (GPU). Each GPU is faster than 16 Intel Pentium cores. The new scanner also provides Reflection Tomography (RT) imaging of refraction corrected (focused) and attenuation calibrated imaging of the collected reflection data. RT data are collected with two horizontal reflection transducers that move in 6 degree steps around 360 degrees. These two RT transducers have focal length of 45 mm and 75 mm to provide a large depth of focus when combined. The RT spatial resolution is about 0.5 mm horizontally and 1.5 mm vertically. These two are complemented by a vertical, compounded, electronic beam-steered transducer, which give 0.5 mm vertical resolution and allow imaging of the chest wall. Further image improvement is provided by soft polymer breast cups that stabilize the breast and control/minimize refraction artifacts. Human studies will commence in the third year at the University of California at San Diego and are intended to expand research on the acoustic properties of breast tissue as a means to classify masses as benign or malignant. Michael Andre will head UCSD work as a PI. The subtlety and complexity of breast tissues and masses in patients are greater than can be achieved in tissue-mimicking phantoms so human studies are essential for evaluating performance of the Partnership Breast Scanner.

描述（由申请人提供）：该学术-工业合作资助计划的重点是开发用于乳腺癌检测的新型超声断层扫描系统（指定为合作扫描仪）。 TechniScan, Inc. 的 Steven A. Johnson 将担任协调 PI。该扫描仪旨在扩展和改进 TechniScan 之前的乳腺超声断层扫描系统（USCT 扫描仪）的功能。该扫描仪提供声速和声衰减的逆散射断层扫描 (IST) 定量成像。目前，IST 图像是由接收器上的 180 个前向散射测量值生成的，该接收器以 2 度的步长在 360 度周围移动。它还以 1 毫米垂直步长移动以扫描三个维度。 IST 空间分辨率水平约为 1.5 mm，垂直约为 2 mm。在五年资助期的前两年半内，将开发新算法并构建升级硬件。新的合作伙伴扫描仪将逆散射接收传感器的数量从 1536 个增加到 3072 个，接收器行数从 8 行增加到 16 行。IST 发射器行数将从 8 行增加到 16 行，以允许垂直波束控制。该计划将在 5 年资助期内改进现有的 IST 和反射断层扫描 (RT) 算法。四个或更多 NVIDIA 图形处理器单元 (GPU) 将提供更高的计算速度。每个 GPU 的速度都快于 16 个 Intel Pentium 内核。新扫描仪还提供折射校正（聚焦）的反射断层扫描（RT）成像和收集的反射数据的衰减校准成像。 RT 数据由两个水平反射传感器收集，这些传感器以 6 度步长围绕 360 度移动。这两个 RT 传感器的焦距分别为 45 毫米和 75 毫米，组合后可提供大焦深。 RT空间分辨率水平方向约为0.5毫米，垂直方向约为1.5毫米。这两者由垂直、复合、电子波束控制传感器进行补充，可提供 0.5 毫米的垂直分辨率并允许对胸壁进行成像。柔软的聚合物乳罩可进一步改善图像，稳定乳房并控制/最小化折射伪影。加州大学圣地亚哥分校将于第三年开始人体研究，旨在扩大对乳腺组织声学特性的研究，作为将肿块分类为良性或恶性的一种手段。 Michael Andre 将作为 PI 领导 UCSD 的工作。患者乳腺组织和肿块的微妙性和复杂性比组织模拟模型所能实现的要大，因此人体研究对于评估合作伙伴乳房扫描仪的性能至关重要。