SARRP 200 Small animal radiation research platform

SARRP 200 小动物辐射研究平台

• 批准号: 8826303
• 负责人: Nicholas C. Denko
• 金额: $ 59.97万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-23 至 2016-03-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8826303
• 关键词: 3-Dimensional; Animal Model; Animals; Brain Neoplasms; Child; Computer software; Computers; Development; Devices; Dimensions; Funding; Future; Human; Immunology; Lead; Manuals; Medical; Medical Genetics; Modality; Modeling; Molecular Virology; Mus; Neurosciences; Ohio; Physics; Radiation; Radiation Oncology; Radiation therapy; Research; Research Institute; Research Personnel; Roentgen Rays; Running; Services; Source; Staging; System; Technology; Therapeutic; Training; Translating; Tube; United States National Institutes of Health; Universities; base; cone-beam computed tomography; design; image guided radiation therapy; implantation; innovation; instrument; neurosurgery; new technology; next generation; novel; programs; ranpirnase; seal; treatment planning; tumor

 DESCRIPTION (provided by applicant): This shared instrument application is to support the purchase of a small animal radiation research platform (SARRP). The technology available from Xstrahl is unique and combines a cone beam CT with a computer controlled rotating treatment x-ray tube. In combination with the treatment planning software, this hardware allows for 3-dimensional radiotherapy treatment planning and delivery to model organisms that mimics the volumetric approach used to treat human tumors. This next-generation system leverages the recent advances in small animal CT to generate true image guided radiotherapy, or IGRT. The device incorporates a 360o rotating gantry with a stage that rotates and translates in 3 dimensions to allow for multiple x-ray beamlets to be delivered from any angle and converge upon the tumor. This system will replace the current technology at Ohio State University that is based on 50 year old design for cabinet X-ray machines. The cabinet x-ray device at Ohio State University is an RS2000, a point source X-ray generator fixed to the top of a sealed cabinet. In order to treat animals, one must use manual placement of lead shielding in such a way as to shield a portion of the mouse and allow x-ray delivery only to the model tumor. The SARRP will enhance the research of 6 major users with 9 currently funded NIH projects that span the departments of Radiation Oncology, Neurosurgery, and Molecular Virology, Immunology and Medical Genetics at OSUCCC and the Experimental Therapeutics program at Nationwide Children's Research Institute. In addition, the SARRP device will be incorporated into the training for the graduate program in medical physics run in the department of Radiation Oncology. Finally, the SARRP will be combined into the services that are offered at the OSU Neuroscience Center (P30) core for orthotopic brain tumor implantation. This core is designed to support the development of new technologies for the treatment of brain tumors. Current and future investigators using this core will now be able to incorporate radiotherapy with their novel modalities in the hope of generating innovative, synergistic therapeutics to treat brain tumors.

 描述（由申请人提供）：该共享仪器申请旨在支持购买小动物辐射研究平台 (SARRP)。Xstrahl 提供的技术是独一无二的，它将锥形束 CT 与计算机控制的旋转治疗 X 射线管结合在一起。与治疗计划软件相结合，该硬件可以进行 3 维放射治疗计划并交付给模型生物，模仿用于治疗人类肿瘤的体积方法。这种下一代系统利用小动物 CT 的最新进展来生成真实的放射治疗。图像该设备采用 360° 旋转机架，其平台可在 3 个维度上旋转和平移，以允许从任何角度发射多个 X 射线束并会聚在肿瘤上。该系统将取代当前的技术。俄亥俄州立大学基于 50 年前的柜式 X 射线机设计 俄亥俄州立大学的柜式 X 射线设备是 RS2000，一种固定在顶部的点源 X 射线发生器。为了治疗动物，必须手动放置铅屏蔽，以屏蔽小鼠的一部分，并仅允许 X 射线照射到模型肿瘤。 SARRP 将加强 6 的研究。目前资助的 9 个 NIH 项目涵盖 OSUCCC 的放射肿瘤学、神经外科、分子病毒学、免疫学和医学遗传学部门以及全国儿童研究所的实验治疗项目。此外，SARRP 设备将被纳入放射肿瘤学系医学物理学研究生课程的培训中，最后，SARRP 将被合并到 OSU 神经科学中心 (P30) 核心提供的原位服务中。该核心旨在支持治疗脑肿瘤的新技术的开发，当前和未来的研究人员现在将能够将放射治疗与他们的新方法结合起来，以期产生创新的、治疗脑肿瘤的协同疗法。