Creating a computerized self-administered version of Comprehensive Behavioral Int

创建综合行为智能的计算机化自我管理版本

• 批准号: 8848891
• 负责人: Michael B Himle
• 金额: $ 42.05万
• 依托单位: PSYC TECH, LTD
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8848891
• 关键词: Address; Adrenergic Agonists; Adverse effects; Adverse event; Age; Antipsychotic Agents; Area; Award; Behavior Therapy; Behavioral; Child; Chronic; Clinical; Clinical Trials; Comorbidity; Computers; Data; Development; Disease; Dose; Family; Feedback; Fees; Frequencies; Gilles de la Tourette syndrome; Habits; Health; Impairment; Individual; Internet; Intervention; Lead; Marketing; Measures; Medication Management; Modeling; Monitor; Motor Tics; Parents; Participant; Patients; Pattern; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Phase; Pilot Projects; Process; Protocols documentation; Provider; Quality of life; Randomized Clinical Trials; Randomized Controlled Trials; Relaxation Therapy; Research; Resources; School-Age Population; Self-Administered; Severities; Site; Small Business Innovation Research Grant; Strategic Planning; Symptoms; Testing; Therapeutic; Tic disorder; Time; Training; Travel; Visit; Vocal Tics; Work; active method; base; commercialization; comparative efficacy; computerized; cost; cost effective; efficacy testing; follow-up; impression; improved; indexing; innovation; neuropsychiatry; preference; programs; prototype; psychosocial; response; satisfaction; secondary outcome; self help; social; usability

DESCRIPTION (provided by applicant): This Phase II SBIR proposes to expand upon our successful Phase I activities to finalize development and test the efficacy of an innovative computer-based treatment-delivery product for children with Chronic Tic Disorders (CTD; including Tourette Disorder) and their families. CTD represents a class of neuropsychiatric disorders, occurring in 0.6-3% of school-aged children that can lead to significant impairments in physical, social, academic, and interpersonal functioning and reduced quality of life. Currently, there is no cure for CTD, however in large-scale randomized controlled trials; a non-pharmacological treatment known as Comprehensive Behavioral Interventions for Tics (CBIT) was shown to reduce tics without the adverse side effects associated with pharmacotherapy. A therapist-guided, empirically validated CBIT protocol is available; however the vast majority of individuals who desire CBIT do not have access to therapists trained in the delivery of this intervention. Given the need for non-pharmacological treatment options for children with CTD, a desire for such treatments by potential end-users, and the absence of practitioners adequately trained in the treatment, there is a clear need for innovative modes of dissemination. Following our recently completed (and successful) Phase I project, the current proposal partners two of the primary developers of the CBIT intervention with PsycTech Ltd., to finalized development and test a highly accessible and relatively inexpensive computerized self-help version of CBIT. Results from our Phase I project demonstrated that a prototype version of TICHELPER received high ratings from both professionals and end-users (children with CTD and their parents) on indices of feasibility, acceptability, and usability. Results from the Phase I pilot study also sho that TICHELPER was effective for reducing core CTD symptoms. Phase I results strongly justify Phase II, during which we will fully develop and test the efficacy of Tic Helper. This Phase II proposal aims to (1) use an iterative feedback process with end-users to develop the remaining core components of the CBIT protocol (i.e., relaxation training, function-based intervention, and the fully developed habit reversal module to address core CTD symptoms) into a self-administered online format, and (2) to compare the efficacy of TICHELPER to an Internet-Based Resources (IBR) condition in a randomized controlled trial.

描述（由申请人提供）：本 II 期 SBIR 提议扩展我们成功的 I 期活动，以完成针对慢性抽动障碍（CTD；包括抽动秽语障碍）儿童的基于计算机的创新治疗交付产品的开发并测试其功效和他们的家人。 CTD 是一类神经精神疾病，发生于 0.6-3% 的学龄儿童，可导致身体、社交、学业和人际功能严重受损，并降低生活质量。目前，CTD 尚无治愈方法，但大规模随机对照试验显示；一种称为抽动综合行为干预 (CBIT) 的非药物治疗方法被证明可以减少抽动，且不会产生与药物治疗相关的不良副作用。可以使用以治疗师为指导、经经验验证的 CBIT 方案；然而，绝大多数想要 CBIT 的人无法获得接受过此类干预培训的治疗师的帮助。鉴于 CTD 儿童需要非药物治疗方案、潜在最终用户对此类治疗的渴望，以及缺乏接受过充分治疗培训的从业人员，显然需要创新的传播模式。继我们最近完成（并成功）的第一阶段项目之后，当前的提案与 PsycTech Ltd. 的 CBIT 干预的两个主要开发商合作，最终完成开发并测试高度可访问且相对便宜的计算机化自助版本的 CBIT。我们第一阶段项目的结果表明，TICHELPER 的原型版本在可行性、可接受性和可用性指标方面获得了专业人士和最终用户（患有 CTD 的儿童及其父母）的高度评价。 I 期试点研究的结果也表明，TICHELPER 可有效减少核心 CTD 症状。第一阶段的结果有力地证明了第二阶段的合理性，在此期间我们将全面开发和测试 Tic Helper 的功效。该第二阶段提案旨在 (1) 使用与最终用户的迭代反馈流程来开发 CBIT 协议的其余核心组件（即放松训练、基于功能的干预以及完全开发的习惯逆转模块，以解决核心 CTD (2) 在随机对照试验中比较 TICHELPER 与基于互联网的资源 (IBR) 条件的疗效。

项目成果

Differentiating tic-related from non-tic-related impairment in children with persistent tic disorders.

区分患有持续性抽动障碍的儿童中抽动相关与非抽动相关的障碍。

• 发表时间: 2018-11
• 影响因子: 7.3
• 作者: Stiede, Jordan T;Alexander, Jennifer R;Wellen, Brianna;Bauer, Christopher C;Himle, Michael B;Mouton;Woods, Douglas W
• 通讯作者: Woods, Douglas W