Institute for Clinical and Translational Science

临床与转化科学研究所

基本信息

批准号：
9045749
负责人：
DAN M COOPER
金额：
$ 165.67万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2015-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9045749
关键词：
Academic Medical Centers Address Adoption Advocacy Architecture Area Basic Science Beds Biological Markers Biophotonics California Cancer Center Caring Center for Translational Science Activities Childhood Clinical Clinical Data Clinical Investigator Clinical Research Clinical Sciences Collaborations Communities Community Health Community Outreach Computerized Medical Record Consultations Data Data Quality Dementia Development Discipline of Nursing Distant Educational process of instructing Elder Abuse Engineering Ensure Exercise Faculty Funding Generations Genomics Goals Grant Health Health Professional Health Sciences Heart Hospitals Human Incubated Individual Information Sciences Information Systems Inpatients Institutes Institution Instruction Interdisciplinary Study Laboratories Leadership Link Medical Medical Students Medical center Mentors Mentorship Methodology Mitochondrial Diseases Molecular Nanotechnology Nomenclature Nurses Nursing Students Obesity Ontology Operations Research Ownership Participant Phase Physicians Population Heterogeneity Positioning Attribute Principal Investigator Process Public Health Qualitative Research Research Research Infrastructure Research Personnel Resources Robotics Role Safety Schools Science Scientist Security Seminal Series Services Structure Students Sudden Death Talents Technology Testing Thirst Training Translational Research Underinsured United States National Institutes of Health Universities Vision Voice Work aging brain authority base biomedical informatics career development clinical investigation comparative effectiveness computer science data management design disease phenotype effectiveness research empowered experience flexibility improved innovation interoperability multidisciplinary new technology next generation novel novel strategies outreach prevent programs protocol development remote sensing response social symposium tool volatile organic compound volunteer

项目摘要

Three years ago, UCI created the Institute for Clinical and Translational Science (ICTS), which identifies tests, and implements innovative ways to break down barriers that impede biomedical discovery. In the next phase of our concerted effort to transform the UCI clinical research enterprise, our vision is to: 1) Nurture Novel Collaborations-The ICTS builds multidisciplinary research teams, such as chemists and clinicians exploring breath biomarkers in the human "ventilome." ICTS experts in the science of team science will help new partnerships to identify and remove obstacles to successful collaboration before they become insurmountable. 2) Create New Technologies for Translational Science-The ICTS made novel UCI-based technologies such as biophotonics and microdevices available to a new generation of clinicians. We will now develop and provide new methodologies by partnering with UCI information scientists in the use of ubiquitous computing for field research; with nursing and social scientists for qualitative and comparative effectiveness research; and with exercise physiologists and molecular biologists for technologies that link genomic information with dynamic disease phenotypes. 3) Share Information-The ICTS has engaged clinicians, hospital IT staff, and scholars from the School of Information and Computer Sciences to create the Center for Biomedical Informatics. We are now ready to embed infrastructure for clinical data interoperability at a unique moment, namely, as UCI begins to deploy its EMR; 4) Engage Our Community-The ICTS championed new approaches such as PEER (Participant Experience Enhancement in Research), a program that views research volunteers as partners in the process of discovery. We plan a range of outreach/dissemination activities, from mitigating elder abuse to preventing sudden death in pediatric athletes. And 5) Train-We will implement Crossing Boundaries, a set of degree and certificate programs along with mentorship interaction that tackles key issues in translational science. Finally, we view ourselves as part of a unique translational science network for Southern California, in which the resources of regional academic medical centers are integrated to better realize the overarching vision of the CTSA. RELEVANCE (See Instructions): UCI is becoming a motivating force for clinical research in this dynamic region of Southern California. The ICTS will support a wide range of projects that will benefit public health, including the ambitious NIH-funded National Childen's Study; research into rare, poorly studied diseases of mitochondrial origin; and community outreach efforts to mitigate the health consequences of obesity among underinsured people in our region.

三年前，UCI 创建了临床和转化科学研究所 (ICTS)，该研究所确定测试，并实施创新方法来打破阻碍生物医学发现的障碍。在接下来的在我们共同努力改造 UCI 临床研究企业的阶段，我们的愿景是： 1) 培育新颖的合作-ICTS 建立了多学科研究团队，例如化学家和临床医生探索人类“ventilome”中的呼吸生物标志物。 ICTS 团队科学领域的专家将提供帮助建立新的伙伴关系，以便在其成为障碍之前识别并消除成功合作的障碍不可逾越。 2）为转化科学创造新技术——ICTS创造了基于UCI的新颖技术新一代临床医生可以使用生物光子学和微型设备等技术。我们现在将通过与 UCI 信息科学家合作，开发并提供新的方法用于现场研究的普适计算；与护理和社会科学家进行定性和比较有效性研究；并与运动生理学家和分子生物学家合作开发将两者联系起来的技术具有动态疾病表型的基因组信息。 3) 共享信息-ICTS已聘请临床医生、医院 IT 人员以及信息与计算机科学学院的学者共同创建了生物医学信息学中心。我们现在准备嵌入临床数据互操作性基础设施在一个独特的时刻，即 UCI 开始部署其 EMR 时； 4) 参与我们的社区 - ICTS 倡导新方法，例如 PEER（研究参与者体验增强）计划将研究志愿者视为发现过程中的合作伙伴。我们计划了一系列外展/传播活动，从减少虐待老年人到预防儿科猝死运动员。 5）培训-我们将实施跨越边界，一套学位和证书课程以及解决转化科学中关键问题的指导互动。最后我们看看自己作为南加州独特的转化科学网络的一部分，其中区域资源学术医疗中心的整合是为了更好地实现 CTSA 的总体愿景。相关性（参见说明）： UCI 正在成为南加州这个充满活力的地区临床研究的推动力。这 ICTS 将支持一系列有利于公共卫生的项目，包括由 NIH 资助的雄心勃勃的项目国家儿童研究；对罕见的、研究较少的线粒体起源疾病的研究；和社区为减轻本地区保险不足人群肥胖造成的健康后果而开展的外展活动。