Microthrombus Formation Triggers Lung Injury in Sepsis

脓毒症中微血栓形成引发肺损伤

• 批准号: 7780052
• 负责人: BRUCE Allan HARMS
• 金额: --
• 依托单位: WM S. MIDDLETON MEMORIAL VETERANS HOSP
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7780052
• 关键词: Abdomen; Acute; Acute Lung Injury; Address; Adult Respiratory Distress Syndrome; Affect; Air; Alveolar; Animals; Anticoagulants; Appearance; Area; Bacteria; Bacterial Translocation; Bacteroides fragilis; Blood; Blood Coagulation Disorders; Blood Vessels; Blood capillaries; Caliber; Cells; Cessation of life; Cicatrix; Clinical; Clinical Trials; Complication; Consumption; Cytotoxic agent; Data; Development; Disease; Epithelial; Erythrocytes; Escherichia coli; Event; FCGR3B gene; Factor Va; Frequencies; Generations; Goals; Healthcare; Hemorrhage; Hour; Immunofluorescence Immunologic; Inflammatory Bowel Diseases; Inflammatory Response; Injury; Intestines; Intra-abdominal; Intravenous infusion procedures; Invaded; Label; Laboratories; Latex Particles; Lead; Lepirudin; Leukocytes; Life; Location; Low-Molecular-Weight Heparin; Lung; Lymph; Manufacturer Name; Measures; Mechanical ventilation; Mediating; Methodology; Methods; Microcirculation; Modeling; Organ failure; Outcome; Pathway interactions; Patients; Pattern; Peptide Hydrolases; Perfusion; Pharmaceutical Preparations; Physiological; Plasma; Prevention; Property; Protein C; Pulmonary Circulation; Pulmonary Edema; Pulmonary alveolar structure; Rat-1; Rattus; Reaction; Recombinants; Reperfusion Injury; Reporting; Resistance; Respiratory Failure; Respiratory distress; Resuscitation; Risk; Risk Factors; Role; Sampling; Sepsis; Solutions; Structure of parenchyma of lung; Surgical complication; System; Testing; Text; Therapeutic; Thrombin; Thromboxane Receptor; Thromboxanes; Thrombus; Time; Tissues; Trauma; United States Food and Drug Administration; Veterans; Vitamin K; Western Blotting; Whole Blood; activated Protein C; analytical method; arteriole; capillary; clinically relevant; combat; drotrecogin alfa; effective therapy; experience; improved; injured; innovation; insight; lung injury; meetings; mortality; neutrophil; particle; patient population; prevent; public health relevance; septic; venule