Life Course Investigation of People Who Inject Drugs

注射吸毒者生命历程调查

基本信息

批准号：
8928767
负责人：
ROBERT Edwin BOOTH
金额：
$ 57.74万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2020-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8928767
关键词：
AIDS prevention AIDS/HIV problem Abstinence Accounting Acquired Immunodeficiency Syndrome Address Affect African American Age Alcohol or Other Drugs use Behavior Birth Centers for Disease Control and Prevention (U.S.)Child Childbirth Cities Colorado Communities Data Drug usage Drug user Environment and Public Health Epidemic Epidemiologic Studies Ethnic Origin Event Female Frequencies Gender Goals HIV HIV Infections HIV risk Health Hepatitis C virus Hispanics Imprisonment Injection of therapeutic agent Intervention Investigation Life Life Cycle Stages Light Literature Mediating Monitor Morbidity - disease rate National Institute of Drug Abuse Natural History Needle Sharing Not Hispanic or Latino Opiates Outcome Overdose Participant Pattern Personality Disorders Pharmaceutical Preparations Play Policies Population Prevention Randomized Controlled Trials Recruitment Activity Relapse Reporting Research Research Project Grants Risk Risk Behaviors Risk Reduction Role Site Time U-Series Cooperative Agreements United States United States National Institutes of Health Vulnerable Populations Woman Work anti social base cohort design grandchild high risk injection drug use male marijuana legalization marijuana use men methadone maintenance mortality outreach pandemic disease prescription opiate public health relevance sex risk trend

项目摘要

DESCRIPTION (provided by applicant) For the past 19 years, we have conducted large randomized controlled trials with out-of- treatment people who inject drugs (PWID) in Denver. This research has been focused on facilitating substance use treatment entry and retention as a means of reducing HIV risk behaviors and drug use. While this work has added substantially to our knowledge of risk behaviors and risk reduction strategies in the short term, major questions remain unanswered regarding the life course of these behaviors. In this proposal, we will assess long term changes in HIV risk behaviors and drug use among PWID with a goal of describing and evaluating the natural history of PWID and identifying important predictors of life course behaviors of PWID. It is hypothesized that HIV risk behaviors, opiate use and mortality will be affected by major life events, such as overdose, incarceration, and policy changes. Also, patterns of HIV risk behavior and drug use maybe affected by other factors such as gender, ethnicity and age. This study will contribute to the literature on prevention of HIV risk behavior and reduction in morbidity and mortality over the life course in this highly vulnerable population of PWID.

描述（由申请人提供）在过去的 19 年里，我们在丹佛对未接受治疗的注射吸毒者 (PWID) 进行了大型随机对照试验。这项研究的重点是促进药物使用治疗的进入和保留。虽然这项工作在短期内大大增加了我们对风险行为和风险降低策略的了解，但有关这些行为的生命周期的主要问题仍未得到解答，我们将在本提案中进行评估。长期变化注射吸毒者中的艾滋病毒危险行为和药物使用，目的是描述和评估注射吸毒者的自然史，并确定注射吸毒者生命过程行为的重要预测因素。人们普遍认为，艾滋病毒危险行为、阿片类药物使用和死亡率将受到主要生活的影响。此外，艾滋病毒危险行为和吸毒模式可能受到性别、种族和年龄等其他因素的影响。这项研究将为预防和减少艾滋病毒危险行为的文献做出贡献。发病率和死亡率超过这个高度脆弱的吸毒者群体的生命历程。