MECHANISMS AND REGULATION OF INTESTINAL CHOLESTEROL TRANSPORT

肠道胆固醇转运的机制和调节

• 批准号: 7784489
• 负责人: Waddah A. Alrefai
• 金额: --
• 依托单位: JESSE BROWN VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7784489
• 关键词: Address; Affect; Atherosclerosis; Binding Proteins; Biochemical; Biological Assay; Caco-2 Cells; Cell Culture Techniques; Cholesterol; Cholesterol Homeostasis; Confocal Microscopy; DNA Binding; Data; Deoxyribonucleases; Development; Diabetes Mellitus; Diet; Dietary Cholesterol; Disease; Dose; Endocrine; Enterocytes; Epithelial Cells; Esterification; Functional disorder; Future; Gel; General Population; Goals; Guidelines; Health; Healthcare; Hormones; Human; In Vitro; Incidence; Individual; Insulin; Insulin Resistance; Intestinal Absorption; Intestines; Knockout Mice; Lead; Maintenance; Mediating; Mediator of activation protein; Mission; Modality; Modeling; Molecular; Molecular Biology Techniques; Molecular Target; Pathway interactions; Patients; Pharmaceutical Preparations; Physiological; Plasma; Play; Prevalence; Process; Rattus; Regulation; Research Design; Response Elements; Role; Schering-Plough brand of ezetimibe; Signal Transduction; Signaling Molecule; Site-Directed Mutagenesis; Small Interfering RNA; Small Intestines; Sterols; Streptozocin; Therapeutic; Time; Transcriptional Regulation; Up-Regulation; Vesicle; Veterans; base; brush border membrane; cardiovascular disorder risk; cholesterol absorption; cholesterol control; cholesterol transporters; chromatin immunoprecipitation; design; diabetic patient; diabetic rat; effective therapy; ezetimibe; feeding; hormone regulation; hypercholesterolemia; improved; in vitro Model; in vivo; inhibitor/antagonist; insight; intestinal crypt; intestinal epithelium; intestinal villi; laser capture microdissection; mRNA Expression; meetings; monolayer; novel; patient population; promoter; public health relevance; response; transcription factor; uptake