Biobehavioral Mechanisms Facilitating Recovery From Stem Cell Transplantation

促进干细胞移植恢复的生物行为机制

基本信息

批准号：
8877431
负责人：
Erin Costanzo
金额：
$ 14.88万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8877431
关键词：
Acute Graft Versus Host Disease Adult Allogenic Autologous Autologous Stem Cell Transplantation Award B-Lymphocytes Behavior Therapy Behavioral Behavioral Medicine Biological Assay Biological Response Modifiers Cancer Biology Cancer Center Cancer Control Cancer Patient Cancer Survivor Caring Clinical Clinical Markers Clinical Psychology Clinical Trials Design Cognitive Cognitive Therapy Complement Complication Comprehensive Cancer Center Development Emotions Ensure Flow Cytometry Future Goals Health Psychology Hematologic Neoplasms Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Homologous Transplantation Immune Immunologic Markers Immunology Immunophenotyping Incidence Individual Infection Inflammatory Intervention Investigation Knowledge Learning Leukocytes Life Experience Malignant Neoplasms Measures Mediating Mediator of activation protein Mentorship Moods Morbidity - disease rate Natural Immunity Natural Killer Cells Outcome Participant Pathway interactions Patient Self-Report Patients Population Population Study Posttraumatic growth Process Protocols documentation Psychological Factors Psychosocial Factor Psychosocial Influences Public Health Quality of life Randomized Controlled Trials Recovery Recurrence Research Research Personnel Research Support Resources Risk Risk Factors Role Sampling Scientist Services Severities Staging Stem cell transplant T-Lymphocyte Techniques Testing Therapeutic Intervention Thinking Training Translating Transplant Recipients Transplantation Universities Wisconsin adaptive immunity base biobehavior cancer prevention chronic graft versus host disease clinically significant cognitive process cytokine design disturbance in affect evidence base experience follow-up graft vs host disease immune function improved innovation medical schools mindfulness monocyte multidisciplinary novel prevent programs prospective psychologic psychosocial reconstitution restoration skills therapy design

项目摘要

DESCRIPTION (provided by applicant): This proposal will support the research and further the applicant's training as a behavioral scientist in cancer prevention and control. Dr. Costanzo's goals are to examine contributions of psychosocial factors to cancer outcomes, to elucidate biobehavioral mechanisms underlying these relationships, and to ultimately translate these findings into targeted behavioral interventions for individuals with cancer. To achieve these aims, a didactic plan focused on the development of: 1) a stronger conceptual grounding in cancer biology and behavioral immunology, and 2) more sophisticated methodological skills including immune assay techniques and advanced analytical strategies, will complement Dr. Costanzo's background in clinical and health psychology. Training objectives will be accomplished through targeted coursework and multidisciplinary mentorship in the context of the comprehensive scholarly resources available at the University of Wisconsin School of Medicine and Public Health. The research plan will utilize knowledge and new techniques learned to investigate novel hypotheses regarding the extent to which mood disturbance can influence the recovery of innate and adaptive immunity following hematopoietic stem cell transplantation (HSCT) and thereby alter clinical outcomes. Adults with hematologic malignancies receiving autologous or allogeneic transplants at the University of Wisconsin Carbone Comprehensive Cancer Center will be evaluated pre-transplant, with a focus on mood disturbance and potential cognitive mediators of mood, including avoidance of unwanted private experiences and capacity to find meaning in this challenging life experience. Follow-up psychological, immune, and biomedical assessments will occur 30, 100, and 200 days post-transplant. The first study of autologous transplant recipients will utilize novel multicolor flow cytometry and immunophenotyping techniques to delineate leukocyte reconstitution following transplant. A second study focused on allogeneic transplant recipients will track inflammatory processes, including systemic cytokine levels, and the development of graft-versus-host disease. This research would be the first prospective examination of psychosocial influences on post-transplant recovery and is designed to set the stage for the applicant to develop, and ultimately test, an evidence-based psychosocial intervention with the potential to meaningfully improve post-transplant outcomes and quality of life. Dr. Costanzo will focus the final years of the award on obtaining training in the design of clinical trials and developing a behavioral intervention tailored to the needs of HSCT recipients. At the end of the award period, Dr. Costanzo will be well-poised to extend her research in several novel directions with clear translational relevance as a fully independent investigator in cancer prevention and control.

描述（由申请人提供）：该提案将支持研究并进一步对申请人作为癌症预防和控制方面的行为科学家进行培训。 Costanzo 博士的目标是检查心理社会因素对癌症结果的影响，阐明这些关系背后的生物行为机制，并最终将这些发现转化为针对癌症患者的有针对性的行为干预措施。为了实现这些目标，教学计划的重点是发展：1）在癌症生物学和行为免疫学方面更强大的概念基础，2）更复杂的方法技能，包括免疫测定技术和先进的分析策略，将补充Costanzo博士的背景临床和健康心理学。培训目标将在威斯康星大学医学与公共卫生学院提供的综合学术资源的背景下，通过有针对性的课程和多学科指导来实现。该研究计划将利用学到的知识和新技术来研究关于情绪障碍在多大程度上影响造血干细胞移植（HSCT）后先天性和适应性免疫恢复并从而改变临床结果的新假设。在威斯康星大学卡本综合癌症中心接受自体或同种异体移植的患有血液恶性肿瘤的成年人将在移植前接受评估，重点是情绪障碍和潜在的情绪认知调节因素，包括避免不想要的私人经历和在生活中寻找意义的能力。这种充满挑战的生活经历。后续心理、免疫和生物医学评估将在移植后 30、100 和 200 天进行。对自体移植受者的第一项研究将利用新型多色流式细胞术和免疫表型技术来描述移植后白细胞的重建。另一项针对同种异体移植受者的研究将追踪炎症过程，包括全身细胞因子水平以及移植物抗宿主病的发展。这项研究将是对移植后恢复的心理社会影响的首次前瞻性研究，旨在为申请人开发并最终测试基于证据的心理社会干预奠定基础，该干预措施有可能有意义地改善移植后的结果和生活质量。 Costanzo 博士将在该奖项的最后几年重点关注获得临床试验设计方面的培训，并开发适合 HSCT 受者需求的行为干预措施。在奖励期结束时，Costanzo 博士将做好准备，作为癌症预防和控制领域完全独立的研究者，将她的研究扩展到几个具有明确转化相关性的新颖方向。