CORTICAL-SUBCORTICAL INTERACTION IN PARKINSON'S DISEASE AND NORMAL SPEECH

帕金森病和正常言语中的皮质-皮质下相互作用

• 批准号: 8167226
• 负责人: DAVID EIDELBERG
• 金额: $ 0.17万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167226
• 关键词: Address; Area; Bilateral; Brain; Cerebrovascular Circulation; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Deep Brain Stimulation; Functional Imaging; Funding; Goals; Grant; Institution; Measures; Motor; Parkinson Disease; Positron-Emission Tomography; Production; Research; Research Personnel; Resources; Role; Source; Speech; Speech Disorders; Symptoms; Thalamic Nuclei; United States National Institutes of Health; motor control

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of deep brain stimulation (DBS) of the sub thalamic nuclei (STN) to treat Parkinson's disease (PD) provides a reversible means of modifying the activity of sub cortical areas. While effective in reducing non speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non speech motor control in PD. Using functional imaging and quantifiable speech production tasks, this project proposes to study the relationships between brain activity in cortical and subcortical regions in subjects with PD, in subjects with PD treated by DBS, and in normal controls. The goal is to better understand cortical subcortical interactions in normal and disordered speech, and the role of such interactions in specific aspects of speech production. Regional cerebral blood flow will be measured during several speech production tasks using positron emission tomography to address four primary specific aims. The first primary specific aim focuses on the relationships between cortical and subcortical areas during speech production in normal subjects. The second primary specific aim focuses on the relationships between cortical and subcortical areas during speech production in PD subjects. The third primary specific aim focuses on the relationships between cortical and subcortical areas during speech production in PD subjects treated with bilateral DBS of the sub-thalamic nuclei. The fourth primary specific aim is to examine and compare the relationships between specific characteristics of speech production and regional cerebral blood flow.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 使用丘脑下核 (STN) 的深部脑刺激 (DBS) 治疗帕金森病 (PD) 提供了一种改变皮质下区域活动的可逆方法。虽然这种治疗形式可以有效减少非言语运动症状，但通常对言语没有影响，甚至有负面影响，这引发了人们对帕金森病中言语和非言语运动控制之间关系的疑问。该项目利用功能成像和可量化的语音产生任务，研究帕金森病患者、接受 DBS 治疗的帕金森病患者以及正常对照者大脑皮层和皮层下区域的大脑活动之间的关系。 目标是更好地理解正常和无序言语中的皮质下相互作用，以及这种相互作用在言语产生的特定方面的作用。 将使用正电子发射断层扫描在几个言语产生任务中测量区域脑血流量，以实现四个主要特定目标。 第一个主要具体目标侧重于正常受试者言语产生过程中皮质和皮质下区域之间的关系。 第二个主要具体目标侧重于 PD 受试者言语产生过程中皮质和皮质下区域之间的关系。 第三个主要具体目标侧重于接受丘脑下核双侧 DBS 治疗的 PD 受试者言语产生过程中皮质和皮质下区域之间的关系。 第四个主要具体目标是检查和比较言语产生的具体特征与局部脑血流量之间的关系。