Molecular Mechanisms of the Inflammatory Response Induced by Shigella flexneri

福氏志贺菌引起炎症反应的分子机制

• 批准号: 8112166
• 负责人: Beth A McCormick
• 金额: $ 41.13万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8112166
• 关键词: ATP-Binding Cassette Transporters; Acute; Africa; Antibiotic Resistance; Apical; Arachidonate 12-Lipoxygenase; Arachidonic Acids; Asia; Bacillary Dysentery; Bacillus (bacterium); Bacteria; Cellular biology; Cercopithecidae; Chemotactic Factors; Clinical; Colitis; Complex; Data; Developed Countries; Development; Diarrhea; Disease; Drug Design; Eicosanoids; Enteral; Epithelial; Exhibits; Feces; Fostering; Functional disorder; Goals; Human; Immunology; Infection; Inflammatory; Inflammatory Response; Intervention; Intestines; Invaded; Lead; Learning; Medical; Membrane Proteins; Modeling; Molecular; Movement; Mucositis; Multi-Drug Resistance; Organism; Pathogenesis; Pathogenicity; Pathway interactions; Pilot Projects; Prevalence; Process; Proteins; Reaction; Role; Shigella; Shigella Infections; Shigella flexneri; Signal Pathway; Signal Transduction; Surface; System; Testing; Therapeutic; Tight Junctions; Time; Up-Regulation; Vaccines; Virulence; Virulence Factors; Xenograft procedure; base; cellular targeting; design; drug development; fetal; foodborne; in vivo Model; insight; interest; intestinal epithelium; migration; monolayer; mortality; neutrophil; new therapeutic target; nonhuman primate; novel; novel therapeutic intervention; novel therapeutics; public health relevance; treatment strategy; weapons