Cortical Potentials and Speech Perception in Children with Auditory Neuropathy

听觉神经病儿童的皮质电位和言语感知

• 批准号: 8191081
• 负责人: Craig A. Buchman
• 金额: $ 22.2万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-05 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8191081
• 关键词: Achievement; Acoustics; Adopted; Affect; Age; Auditory; Auditory Evoked Potentials; Auditory area; Child; Clinical; Cochlea; Cochlear Hearing Loss; Cochlear Implants; Complex; Devices; Diagnostic; Disease; Early treatment; Electric Stimulation; Etiology; Event-Related Potentials; Evoked Potentials; Exhibits; Goals; Habilitation; Hearing; Hearing Aids; Implant; Individual; Intervention; Language Development; Measures; Neuropathy; Outcome; Patients; Performance; Population; Process; Pure-Tone Audiometry; Rehabilitation therapy; Research; Severities; Speech; Speech Development; Speech Perception; Syndrome; System; Testing; Work; clinical practice; hearing impairment; otoacoustic emission; programs; relating to nervous system; research clinical testing; research study; response; success; tool

DESCRIPTION (provided by applicant): Children with Auditory Neuropathy Spectrum Disorder present a challenge for early intervention and habilitation because of the diversity of the disorder and the current lack of robust indicators to guide in management of this population. These challenges can result in significant delays in selecting and implementing appropriate interventions such as hearing aids and/or cochlear implants. This project focuses on cortical auditory evoked potentials as a class of objective electrophysiological measures that hold great promise in the prediction of intervention outcomes. The proposed work evaluates the association between these potentials and speech perception in children with this disorder by pursuing two specific aims. Aim 1 focuses on the sub- group of children who use hearing aids and evaluates the utility of acoustically-evoked cortical potentials for predicting success with these devices. Aim 2 focuses on the sub-group of children who use cochlear implants and evaluates the relationship between electrically-evoked cortical potentials and speech perception. Cortical potentials (P1-N1-P2 complex and the change complex) will be recorded from each child in response to either acoustical or electrical stimulation, as appropriate for their device. In addition, aided speech perception performance will be measured using age- and developmentally-appropriate tests. Correlations between the electrophysiological measures and speech perception performance will then be assessed. The goal of these experiments is to identify electrophysiological response features that are most informative in terms of guiding intervention strategy. As such, this project has tremendous translational significance because its findings are likely to directly impact clinical practice. PUBLIC HEALTH RELEVANCE: Experiments are proposed to evaluate the relationship between the electrophysiological measures of cortical evoked potentials and the speech perception performance in children with auditory neuropathy spectrum disorder (ANSD). The ultimate goal of the proposed study is to develop tools for early and accurate identification of the best rehabilitative strategy for each individual patient. It is likely that the electrophysiological measures investigated in this program of research might be adopted as part of clinical test-battery for ANSD patients, which will have an important impact on clinical practice.

描述（由申请人提供）：患有听觉神经病谱系障碍的儿童对早期干预和康复提出了挑战，因为该疾病的多样性以及目前缺乏强有力的指标来指导该人群的管理。这些挑战可能会导致选择和实施适当干预措施（例如助听器和/或人工耳蜗）的严重延误。该项目的重点是皮质听觉诱发电位作为一类客观的电生理测量方法，在预测干预结果方面具有广阔的前景。拟议的工作通过追求两个特定目标来评估患有这种疾病的儿童的这些潜力与言语感知之间的关联。目标 1 重点关注使用助听器的儿童亚组，并评估声诱发皮层电位在预测这些设备成功使用方面的效用。目标 2 重点关注使用人工耳蜗的儿童亚组，并评估电诱发皮层电位与言语感知之间的关系。根据适合其设备的情况，将记录每个孩子对声刺激或电刺激的反应的皮质电位（P1-N1-P2 复合体和变化复合体）。此外，将使用适合年龄和发育的测试来测量辅助言语感知表现。然后将评估电生理测量和言语感知表现之间的相关性。这些实验的目的是确定在指导干预策略方面最具信息性的电生理反应特征。因此，该项目具有巨大的转化意义，因为其发现可能直接影响临床实践。 公共健康相关性：建议进行实验来评估皮层诱发电位的电生理测量与听神经病谱系障碍（ANSD）儿童的言语感知表现之间的关系。拟议研究的最终目标是开发工具，以便尽早准确地确定每个患者的最佳康复策略。本研究项目中研究的电生理学措施可能会被采用作为 ANSD 患者临床试验的一部分，这将对临床实践产生重要影响。