Oxidative Stress & Inflammation in Aging: Insights from Sickle Cell Disease

氧化应激

基本信息

批准号：
7881615
负责人：
Joan Denise Beckman
金额：
$ 3.34万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7881615
关键词：
Acute-Phase Proteins Address Affect Age Aging Aging-Related Process Alzheimer&apos s Disease Amyloid beta-Protein Anemia Binding Biological Models Blood Vessels C-reactive protein CD40 Ligand Carbon Monoxide Cardiovascular Diseases Cell Adhesion Molecules Cells Chronic Chronic Kidney Failure Development Disease Elderly Endothelial Cells Enzymes Free Radicals Functional disorder Gene Delivery Gene Expression Gene Transduction Agent Heme Hemolysis Inflammation Inflammation Mediators Inflammatory Injury Interleukin-6 Iron Iron Chelating Agents Knowledge Learning Leukocytosis Link Malignant Neoplasms Mediating Metabolism Mission Mitochondria Modeling Morbidity - disease rate Mus Nature Organ Oxidative Stress Pain Pathogenesis Pathology Patients Pattern Peripheral arterial disease Physiological Platelet Activating Factor Play Population Premature Mortality Prevention Process Proteins Quality of life Reactive Oxygen Species Reperfusion Injury Research Role Science Serum Sickle Cell Anemia Signal Transduction Stroke Temporal Lobe Thrombin Tissues Transcription Alteration Transgenic Organisms Up-Regulation Viral aged base cancer type cytokine genetic manipulation heme oxygenase-1 improved functioning inflammatory marker innovation insight macromolecule mortality novel oxidant stress oxidative damage prevent response sickling vascular inflammation

项目摘要

DESCRIPTION (provided by applicant): Vascular inflammation and oxidative stress are fast becoming key components of aging science. However, the interaction been these two entities is often not addressed in current research. To address these issues, a basic understanding of the pathophysiology of oxidative stress and vascular inflammation that results in vaso-occlusion is required. Closing this gap in knowledge will be the focus of this proposal. We will examine the link between hemolysis, oxidative stress, vascular inflammation and vaso-occlusion during aging using sickle cell disease as a model. We will learn from nature's protective response to excessive heme burden, the induction of HO-1. We will modulate HO-1 to decrease oxidative stress and vascular inflammation and prevent vaso-occlusion. New therapies which can decrease oxidative stress and vascular inflammation will result from these studies. Preventing vaso-occlusion will protect organ function, improve quality of life, and reduce morbidity and mortality. This proposal supports the mission of NIA by its focus on research that will develop and evaluate innovative treatments related to the prevention and treatment of oxidative stress and vascular inflammation. This proposal will advance the field by providing a clear understanding of the link between hemolysis, vascular inflammation, oxidative stress, and vaso-occlusion.

描述（由申请人提供）：血管炎症和氧化应激正在迅速成为衰老科学的关键组成部分。然而，当前的研究通常没有解决这两个实体的相互作用。为了解决这些问题，需要对导致血管闭塞的氧化应激和血管炎症的病理生理学有基本的了解。缩小这一知识差距将是本提案的重点。我们将以镰状细胞病为模型，研究衰老过程中溶血、氧化应激、血管炎症和血管闭塞之间的联系。我们将学习大自然对过量血红素负荷的保护性反应，即 HO-1 的诱导。我们将调节 HO-1 以减少氧化应激和血管炎症并预防血管闭塞。这些研究将产生可以减少氧化应激和血管炎症的新疗法。预防血管闭塞将保护器官功能，提高生活质量，并降低发病率和死亡率。该提案支持 NIA 的使命，重点关注开发和评估与预防和治疗氧化应激和血管炎症相关的创新疗法的研究。该提案将通过提供对溶血、血管炎症、氧化应激和血管闭塞之间联系的清晰理解来推进该领域的发展。