The role of clock protein phosphorylation and degradation in circadian biology

时钟蛋白磷酸化和降解在昼夜节律生物学中的作用

• 批准号: 8062811
• 负责人: JOANNA Chungyen CHIU
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8062811
• 关键词: 26S proteasome; Affect; Affinity Chromatography; Alcohol dependence; Animal Model; Animals; Automobile Driving; Behavioral; Binding; Biology; CSNK2A1 gene; Cell Nucleus; Chronic; Circadian Rhythms; Clock protein; Cytoplasm; Defect; Degradation Pathway; Disease; Docking; Drosophila genus; Drosophila melanogaster; Drosophila period protein; Elderly; Equilibrium; Event; F Box Domain; F-Box Proteins; Feedback; Goals; Homologous Gene; Human; Institution; Link; Lysine; Malignant Neoplasms; Mammals; Maps; Mass Spectrum Analysis; Mediating; Mentors; Metabolic syndrome; Metabolism; Modification; Molecular; Monitor; Mutagenesis; Mutation; Output; Pathway interactions; Pharmaceutical Preparations; Phase; Phospho-Specific Antibodies; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiological; Physiological Processes; Play; Predisposition; Protein Kinase; Protein phosphatase; Proteins; Public Health; Regulation; Research; Role; Scientist; Seasonal Affective Disorder; Site; Sleep Disorders; System; Time; Ubiquitin; base; casein kinase; circadian pacemaker; genetic manipulation; in vitro Assay; in vivo; inhibitor/antagonist; insight; mRNA Expression; multicatalytic endopeptidase complex; novel; protein function; protein protein interaction; tissue culture