Direct Regulation of GnRH neuronal function by P13K activity

P13K 活性直接调节 GnRH 神经元功能

• 批准号: 8049403
• 负责人: MARICEDES ACOSTA
• 金额: $ 24.9万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-15 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8049403
• 关键词: 1-Phosphatidylinositol 3-Kinase; Achievement; Address; Affect; Afferent Neurons; Animals; Antibodies; Award; Behavioral Assay; Brain; Breeding; Cells; Cues; Desire for food; Disease; Endocrine System Diseases; Environment; Enzymes; Experimental Models; Faculty; Female; Fertility; Food; Gene Expression; Genes; Genetic; Glucose; Goals; Gonadotropin Hormone Releasing Hormone; Gonadotropins; Green Fluorescent Proteins; Hormonal; Hormones; Hypogonadism; Hypothalamic structure; Immunohistochemistry; Incidence; Infertility; Insulin; Insulin Receptor; Insulin-Like Growth Factor I; Knockout Mice; Leptin; Mediating; Mentors; Mentorship; Metabolic; Metabolic Diseases; Metabolism; Mission; Modeling; Molecular; Molecular Genetics; Mus; National Institute of Child Health and Human Development; Neurons; Neurosecretion; Non-Insulin-Dependent Diabetes Mellitus; Nutritional status; Obesity; Organism; Ovarian; Pathway interactions; Peripheral; Phase; Physiological; Population; Positioning Attribute; Proto-Oncogene Proteins c-akt; Rattus; Regulation; Reproduction; Research; Research Personnel; Resources; Reverse Transcriptase Polymerase Chain Reaction; Role; Signal Pathway; Signal Transduction; Signaling Molecule; Societies; Somatomedins; Syndrome; Testing; Tissues; Training; Transgenic Mice; Transgenic Organisms; Universities; Woman; blood glucose regulation; energy balance; enzyme activity; feeding; food restriction; genetic analysis; in vivo; insulin signaling; mutant; nutrition; obesity treatment; pituitary gonadal axis; prevent; programs; promoter; recombinase; relating to nervous system; reproductive; reproductive axis; reproductive success; response; restoration; skills; tripolyphosphate