FASEB 2010 Meeting On Nucleic Acid Enzymes

FASEB 2010 核酸酶会议

• 批准号: 7908473
• 负责人: PHILIP C BEVILACQUA
• 金额: $ 0.4万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908473
• 关键词: American; Area; Basic Science; Biochemistry; Biological; Biology; Biotechnology; Cells; Cellular biology; DNA; Diagnosis; Enzymatic Biochemistry; Enzymes; Exposure to; Faculty; Fostering; Genetic Transcription; Human; Hydrolysis; Link; Malignant Neoplasms; Medical; Medicine; Metabolic Diseases; Methods; Modification; Motor; Nucleic Acids; Oral; Patients; Play; Postdoctoral Fellow; Process; RNA; Reaction; Recruitment Activity; Regulation; Research; Research Personnel; Role; Science; Scientist; Small RNA; Societies; Stratification; Structural Biologist; Structure; Students; Translations; Woman; Work; carcinogenesis; graduate student; human disease; insight; interdisciplinary collaboration; interest; meetings; phosphodiester; polymerization; posters; prognostic; programs; public health relevance; repaired; structural biology; symposium; tool

DESCRIPTION (provided by applicant): The FASEB 2010 meeting entitled "Nucleic Acid Enzymes" will focus on the structures, mechanisms, biological roles, and medical relevance of enzymes that are composed of, and/or act on DNA and RNA. The meeting attracts a broad cross-disciplinary group of scientists with expertise in structural biology, biochemistry, and cell biology. This meeting will be the 8th sponsored by the Federation of American Societies of Experimental Biology (FASEB) in this area; the most recent was in 2008. The meeting provides a unique forum for discussion of enzymes that are composed of or act on nucleic acids, the central role of DNA and RNA enzymology in biotechnology, and the metabolic disorders and diseases in which nucleic acid enzymes are implicated. By gathering structural biologists, biochemists, chemists, cell biologists and clinicians-groups that often do not speak to each other-new interests, new insights and interdisciplinary collaboration are fostered. The Scientific Program will consist of nine sessions of oral presentations by distinguished invited speakers, junior faculty, and student poster talks in the following subject areas: (1, 2) Phosphodiester hydrolysis; (3) Phosphoryl transfer; (4, 5) Nucleic acid processing and modification; (6, 7) Motors, Machines and Translocation; (8) Polymerization reactions; and (9) Emerging Methods, Approaches, and Areas. Importantly, we will feature young investigators throughout the meeting, rather than in a single session as in the past; this will be done so that these investigators can receive full exposure to their more senior colleagues. The organizers have recruited leading investigators to serve as discussion leaders for these sessions. The Program will also include four poster sessions, from which outstanding posters from graduate students, post-doc, and other faculty attendees will be selected for short oral presentations. To foster a 'fresh' approach and significant intellectual turnover and renewal, the majority of invited speakers are new to the meeting, and a significant percentage are junior faculty and women in science. The FASEB 2010 meeting aims to have sessions that are broadly enough defined that PIs from different fields will interact in one session. We feel that this is the best means to catalyze fresh exchange of ideas among the attendees. For example, in most cases the biology of DNA and RNA enzymes are quite distinct; however, the tools and approaches are similar and therefore sessions that cross areas defined by the biology provide fertile ground for exchange of ideas. The intimate format of the conference will promote free exchange of information and ideas among researchers working on diverse aspects of RNA and DNA enzymes, thereby expediting research in both fields. PUBLIC HEALTH RELEVANCE: Enzymes that act on nucleic acids are indispensable components of basic research and biotechnology; they are also taking on prominent roles in medicine as the analysis and manipulation of DNA and RNA from patients is integrated into the diagnosis, prognostic stratification, and choice of therapy in human disease states, especially cancers. Aberrations of nucleic acid enzymology that result in the loss of fidelity in replication, repair, and transcription are linked directly to human carcinogenesis. RNA plays a central role in human disease through small RNAs, transcription, and translation fidelity and regulation.

描述（由申请人提供）：题为“核酸酶”的 FASEB 2010 会议将重点关注由 DNA 和 RNA 组成和/或作用于 DNA 和 RNA 的酶的结构、机制、生物学作用和医学相关性。这次会议吸引了广泛的跨学科科学家小组，他们在结构生物学、生物化学和细胞生物学方面拥有专业知识。本次会议将是美国实验生物学会联合会（FASEB）在该领域主办的第八次会议；最近一次是在 2008 年。该会议提供了一个独特的论坛，讨论由核酸组成或作用于核酸的酶、DNA 和 RNA 酶学在生物技术中的核心作用，以及核酸酶参与的代谢紊乱和疾病。受牵连。通过聚集结构生物学家、生物化学家、化学家、细胞生物学家和临床医生（这些通常互不交流的群体），可以培养新的兴趣、新的见解和跨学科合作。该科学计划将包括九场口头报告，由杰出的受邀演讲者、初级教师和学生海报演讲组成，涉及以下主题领域：(1, 2) 磷酸二酯水解； (3)磷酰基转移； (4、5)核酸加工及修饰； (6, 7) 电机、机器和移位； (8)聚合反应； (9) 新兴方法、途径和领域。重要的是，我们将在整个会议中邀请年轻的研究人员，而不是像过去那样只在一次会议上进行；这样做是为了让这些调查人员能够充分接触其更资深的同事。组织者招募了主要研究人员作为这些会议的讨论领导者。该计划还将包括四场海报会议，将从研究生、博士后和其他教职员工中选出优秀的海报进行简短的口头演讲。为了促进“新鲜”方法和显着的知识流动和更新，大多数受邀演讲者都是会议的新成员，其中很大一部分是科学领域的初级教师和女性。 FASEB 2010 会议的目标是召开足够广泛的会议，以便来自不同领域的 PI 能够在一场会议中进行互动。我们认为这是促进与会者之间新的思想交流的最佳方式。例如，在大多数情况下，DNA 和 RNA 酶的生物学特性是截然不同的。然而，工具和方法是相似的，因此跨生物学定义领域的会议为思想交流提供了肥沃的土壤。会议的亲密形式将促进从事 RNA 和 DNA 酶不同方面研究的研究人员之间自由交流信息和想法，从而加快这两个领域的研究。 公共健康相关性：作用于核酸的酶是基础研究和生物技术不可或缺的组成部分；它们还在医学领域发挥着重要作用，因为对患者 DNA 和 RNA 的分析和操作被纳入人类疾病状态（尤其是癌症）的诊断、预后分层和治疗选择中。导致复制、修复和转录保真度丧失的核酸酶学异常与人类致癌直接相关。 RNA 通过小 RNA、转录、翻译保真度和调节在人类疾病中发挥着核心作用。