Biomaterials that Prevent Biofilm Colonization and Device-based Infections

防止生物膜定植和设备感染的生物材料

基本信息

批准号：
7805560
负责人：
James D. Bryers
金额：
$ 42.46万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7805560
关键词：
2-hydroxyethyl methacrylate Academy Adhesions Albumins American American Association for the Advancement of Science Anti-Inflammatory Agents Anti-inflammatory Antibiotic Resistance Antibiotic Therapy Antibiotics Area Artificial Heart Artificial cardiac pacemaker Arts Bacteria Bacteriology Basic Science Binding Biochemical Biocompatible Materials Biological Biological Assay Biomedical Engineering Blood Blood Platelets Blood Vessel Prosthesis Blood Vessels Blood capillaries Caliber Catheters Cause of Death Cell Adhesion Cell Survival Cells Cellular biology Cerebrospinal fluid shunts procedure Cessation of life Chairperson Chemical Engineering Chemicals Chemistry Chimeric Proteins Chronic Ciprofloxacin Clinical Commit Communities Complex Consultations Contact Lenses Control Groups Development Device Removal Devices Doctor of Philosophy Dose Drug Controls Drug Formulations Employee Endothelial Cells Engineering Exhibits Faculty Fibrinogen Fibronectins Figs - dietary Film Foreign Bodies Foreign-Body Giant Cells Funding Gallium Generic Drugs Glycoproteins Goals Growth Growth Factor Healed Heart Valve Prosthesis Heart Valves Hernia Hospitals Hydrogels Immune response Immunoglobulins Implant In Vitro Individual Infection Infection prevention Inflammation Institutes Intrauterine Devices Iowa Iron Journals Laboratories Lead Leadership Left Legal patent Ligand Binding Liquid substance Macor Mammalian Cell Materials Testing Medical Medical Device Medicine Microbial Biofilms Microbiology Modeling Montana Mus Nosocomial Infections Nutrient Ocular Prosthesis Opsonin Organism Orthopedics Pacemakers Pathogenesis Patients Performance Periodontitis Phagocytosis Plasma Polymer Chemistry Polymers Porosity Postdoctoral Fellow Prevention Process Prosthesis Proteins Pseudomonas aeruginosa Publishing Recruitment Activity Relative (related person)Reporting Research Research Personnel Research Project Grants Resistance development Resources Respiration Rice Risk Role Science Series Shunt Device Siderophores Signal Transduction Societies Staging Staphylococcus epidermidis Stomach Surface Surgeon Suspension Culture Switzerland System Technology Testing Text Thromboembolism Thrombosis Time Tissue Engineering Tissue membrane Tissues Titanium United States Department of Veterans Affairs United States National Academy of Sciences United States National Institutes of Health Universities Up-Regulation Vacuum Vascular Graft Virulence Factors Vitronectin Washington Water Work Wound Healing Writing analog angiogenesis antimicrobial base capillary capsule cell growth college controlled release cost cytokine density design design and construction editorial extracellular fluid flow healing implantable device in vivo intercellular communication iron metabolism killings macrophage medical implant medical schools member microbial new technology poly(2-hydroxyethyl methacrylate)-polyamine graft copolymer polyether urethane prevent professor programs quorum sensing receptor reconstruction regenerative repaired response social stressor tissue culture tissue regeneration urinary ventricular assist device

项目摘要

DESCRIPTION (provided by applicant): In this 5-yr Bioengineering Research Grant (BRG), we will develop a class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections. Our group comprises experts in biomaterials synthesis and characterization, controlled drug release, inflammation and immune response, biofilm dynamics, microbial pathogenesis, and antibiotic resistance. Collectively, our group will deliver to clinical reality new technologies that will prevent biofilm formation and/or disrupt existing medical biofilms. Specific aims of this BRG will be the following: Aim 1. Develop porous "templated" constructs (PTCs) that promote healing while preventing bacterial biofilm formation. Aim 2. Quantify, in vitro, the efficacy of various PTCs to promote healing while preventing bacterial colonization. Aim 3. Quantify, in vivo, the efficacy of the PTCs optimized in Aim 2 to promote healing and prevent biofilm colonization. It is estimated that over 5 million artificial or prosthetic devices are implanted per annum in the U.S. alone. However, 70% of hospital-acquired infections are associated with implants or indwelling medical devices, with the case-to-fatality ratio between 5-50%. In this 5-yr Bioengineering Research Grant (BRG), we will develop a class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections.

描述（由申请人提供）：在这项为期 5 年的生物工程研究补助金 (BRG) 中，我们将开发一类生物材料，可以促进愈合，同时防止细菌定植和随后的感染。我们的团队由生物材料合成和表征、药物控制释放、炎症和免疫反应、生物膜动力学、微生物发病机制和抗生素耐药性方面的专家组成。总的来说，我们的团队将向临床现实提供新技术，以防止生物膜形成和/或破坏现有的医疗生物膜。该 BRG 的具体目标如下：目标 1. 开发多孔“模板”结构 (PTC)，促进愈合，同时防止细菌生物膜形成。目标 2. 在体外量化各种 PTC 在促进愈合同时防止细菌定植的功效。目标 3. 在体内量化目标 2 中优化的 PTC 促进愈合和防止生物膜定植的功效。据估计，仅在美国每年就有超过 500 万个人工或假肢装置被植入。然而，70% 的医院获得性感染与植入物或留置医疗器械有关，病死率在 5-50% 之间。在这项为期 5 年的生物工程研究补助金 (BRG) 中，我们将开发一类生物材料，可以促进愈合，同时防止细菌定植和随后的感染。