Metal Chelators and thiols in Endothelial Function and CVD

内皮功能和 CVD 中的金属螯合剂和硫醇

• 批准号: 7902737
• 负责人: BALZ B FREI
• 金额: $ 45.97万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7902737
• 关键词: Affect; Aging; Amyotrophic Lateral Sclerosis; Animal Model; Anti-Inflammatory Agents; Anti-inflammatory; Atherosclerosis; Cell Adhesion; Cell Adhesion Molecules; Centers of Research Excellence; Chelation Therapy; Complementary and alternative medicine; Goals; Inflammation; Metals; Program Research Project Grants; Role; Signal Transduction; Stress; Sulfhydryl Compounds; Thioctic Acid; Transition Elements; antioxidant therapy; metal chelator; programs; protective effect; transcription factor

P01 AT002034 (Frei) 09/30/03-05/31/08 NIH/NCCAM Center of Excellence for Research on Complementary and Alternative Medicine Antioxidant Therapies (CERCAT) The major goals of this program project grant are to determine the roles of oxidative and nitrative stress in animal models of atherosclerosis, Lou Gehrig's disease, and aging, and the protective effects of lipoic acid and metal chelation therapy. The major goals of Project 1 (Metal Chelators and Thiols in Endothelial Function and CVD) are to understand the mechanisms by which thiol compounds and transition metals affect redoxsensitive cellular signaling and transcription factor activation; and to investigate in animal models of inflammation and atherosclerosis whether lipoic acid and metal chelators exert anti-inflammatory and antiatherosclerotic effects by inhibiting cellular adhesion molecule expression. Roles: Program Director, Project 1 Leader (Metal Chelators and Thiols in Endothelial Function and CVD), and Administrative Core Director

P01 AT002034（免费）09/30/03-05/31/08 美国国立卫生研究院/国家癌症中心 补充和替代医学抗氧化疗法研究卓越中心 （塞卡特） 该计划项目拨款的主要目标是确定氧化和硝化应激在动脉粥样硬化、卢伽雷氏病和衰老动物模型中的作用，以及硫辛酸和金属螯合疗法的保护作用。项目1（内皮功能和CVD中的金属螯合剂和硫醇）的主要目标是了解硫醇化合物和过渡金属影响氧化还原敏感细胞信号传导和转录因子激活的机制；并在炎症和动脉粥样硬化动物模型中研究硫辛酸和金属螯合剂是否具有抗炎和抗动脉粥样硬化作用 通过抑制细胞粘附分子的表达来发挥作用。 角色：项目总监、项目 1 负责人（内皮功能和 CVD 中的金属螯合剂和硫醇）以及行政核心总监