Oxygen-Mediated Initiation of Thiol-ene Adhesives and Sealants

硫醇烯粘合剂和密封剂的氧介导引发

• 批准号: 7876056
• 负责人: Timothy Francis Scott
• 金额: $ 21.65万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7876056
• 关键词: Acrylates; Address; Adhesions; Adhesives; Air; Attention; Bandage; Benchmarking; Biocompatible; Biological; Cells; Chemicals; Clinical; Composite Resins; Cyanoacrylates; Dental; Development; Diffusion; Drug Formulations; Encapsulated; Environment; Evaluation; Evolution; Exposure to; Fibrinogen; Gel; Generations; Glass; Goals; Growth; Heating; Hemostatic function; Hydrogels; In Situ; Kinetics; Knowledge; Liquid substance; Mechanics; Mediating; Medical; Methods; Modeling; Modification; Operative Surgical Procedures; Oxygen; Plant Resins; Polymers; Preparation; Procedures; Process; Property; Reaction; Research; Resistance; Scheme; Site; Solvents; Stress; Sulfhydryl Compounds; Surgical sutures; System; Temperature; Testing; Thick; Thrombin; Time; Tissue Adhesives; Transition Temperature; Variant; Work; base; biomaterial compatibility; crosslink; design; improved; in vivo; mathematical model; monomer; novel; polymerization; pressure; public health relevance; restoration; restorative dentistry; restorative resins; restraint; usability; wound

DESCRIPTION (provided by applicant): Several materials and approaches for tissue adhesives and sealants have emerged; however, substantial research attention is still required to fully realize the potential of materials that can be applied to a wound site in liquid form and solidify in situ, alleviating the need for sutures or bandages. Although radical-mediated polymerizations are an attractive means for fabricating materials for use in biological applications, owing to their ability to rapidly cure without solvent at room temperature, the majority of radical-mediated polymerizations are susceptible to oxygen inhibition. In the proposed work, oxygen initiates rather than inhibits the polymerization, therefore eliciting the counter effect. We propose novel, oxygen-mediated thiol-ene polymerization systems to address the shortcomings of current approaches to in situ polymerization for medical procedures. This approach for the initiation of thiol-ene polymerization is analogous to cyanoacrylate polymerization, where liquid monomer remains stable while in its packaging but, upon application to a wound site, cures rapidly. However, unlike cyanoacrylates, the chemical and mechanical properties of thiol-ene materials are readily varied. Initially, approaches for oxygen-mediated radical generation will be developed to initiate thiol-ene polymerization. Subsequently, thiol-ene resins, utilizing these oxygen-mediated initiation schemes for biomedical adhesives and sealants, will be formulated and benchmarked against commercial materials. Finally, modeling of the polymerization will be performed to guide and optimize formulation development with respect to application constraints such as thickness and temperature rise due to polymerization. PUBLIC HEALTH RELEVANCE: This project seeks to develop thiol-ene biomedical adhesives and sealants which polymerize upon exposure to oxygen. Utilizing thiol-ene systems, which demonstrate superior mechanical properties, biocompatibility, and ability to rapidly cure at ambient conditions, is expected to greatly improve upon both the utility and efficacy of existing materials.

描述（由申请人提供）：已经出现了几种用于组织粘合剂和密封剂的材料和方法；然而，仍需要大量的研究关注，以充分实现能够以液体形式应用于伤口部位并在原位固化的材料的潜力，从而减少对缝合线或绷带的需求。尽管自由基介导的聚合是制造生物应用材料的一种有吸引力的方法，但由于其能够在室温下无需溶剂而快速固化，但大多数自由基介导的聚合对氧抑制敏感。在所提出的工作中，氧气引发而不是抑制聚合，因此引发了反作用。我们提出了新型氧介导的硫醇-烯聚合系统，以解决当前医疗程序中原位聚合方法的缺点。这种引发硫醇-烯聚合的方法类似于氰基丙烯酸酯聚合，其中液体单体在其包装中保持稳定，但在应用于伤口部位后迅速固化。然而，与氰基丙烯酸酯不同，硫醇烯材料的化学和机械性能很容易变化。 最初，将开发氧介导自由基生成的方法来引发硫醇-烯聚合。随后，将利用这些用于生物医学粘合剂和密封剂的氧介导引发方案来配制硫醇-烯树脂，并针对商业材料进行基准测试。最后，将进行聚合建模，以指导和优化针对应用限制（例如聚合引起的厚度和温升）的配方开发。 公共健康相关性：该项目旨在开发硫醇烯生物医学粘合剂和密封剂，这些粘合剂和密封剂在暴露于氧气时会聚合。利用硫醇-烯系统表现出优异的机械性能、生物相容性以及在环境条件下快速固化的能力，预计将大大提高现有材料的实用性和功效。