Novel Algorithms and Device for Quantification of Wake-Sleep States

用于量化唤醒睡眠状态的新算法和设备

• 批准号: 7922145
• 负责人: Stephane Bibian
• 金额: $ 64.28万
• 依托单位: NEUROWAVE SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-27 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7922145
• 关键词: Accident and Emergency department; Accidents; Adult; Affect; Algorithms; Ambulances; Apnea; Arousal; Arts; Brain; Caregivers; Caring; Characteristics; Chronic Insomnia; Clinic; Clinical; Computer software; Control Groups; Controlled Study; Data; Dependency; Detection; Development; Devices; Diagnosis; Drowsiness; Elderly; Electrodes; Electroencephalogram; Environment; Evaluation; Event; Frequencies; Functional disorder; Goals; Grant; Hand; Home environment; Hour; Individual; Life; Magnetism; Maintenance; Medical; Mental Depression; Mental disorders; Methods; Modification; Monitor; Morphologic artifacts; National Institute of Neurological Disorders and Stroke; Neurology; Noise; Output; Patients; Performance; Persons; Pharmaceutical Preparations; Pharmacotherapy; Phase; Polysomnography; Prevalence; Primary Insomnia; Programming Languages; Recording of previous events; Research; Resolution; Running; Seizures; Severities; Shapes; Shock; Signal Transduction; Site; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Sleep Disorders; Sleep Fragmentations; Sleep Initiation and Maintenance Disorders; Sleep Stages; Sleeplessness; Sports; Structure; Substance abuse problem; Symptoms; System; Techniques; Testing; Time; Treatment outcome; United States National Institutes of Health; Validation; Wakefulness; alertness; awake; base; behavior test; computerized; computerized data processing; cost; data acquisition; design; detector; digital; ergonomics; improved; indexing; innovation; laptop; miniaturize; neurobehavioral test; novel; operation; pressure; public health relevance; research clinical testing; sleep onset; socioeconomics; vibration; volunteer

DESCRIPTION (provided by applicant): The overall goal of this project is to develop the means (hardware, algorithm, electrode attachments) for a fundamentally improved method for long-term monitoring of sleep architecture and quality, as well as daytime sleepiness. The device that will be developed in this project, (referred to as NeuroLOG"), will be utilized for assessment of sleep disorders and daytime sleepiness with a particular emphasis on the diagnosis and management of primary insomnia. Chronic insomnia affects 10-15% of adults (with a prevalence of 57% in non-institutionalized elderly persons), and an additional 25 to 35 percent of adults have transient or occasional insomnia. Insomnia is associated with significant personal and socioeconomic burden, and is largely under- recognized and inadequately or inappropriately treated (including overmedication). The specific aim of the project is to develop NeuroLOG as a wearable (and easily deployable by the patient), fully-automated, and (highly) quantitative analyzer of brain waves and wake-sleep stages for extended night- time sleep, and daytime sleepiness, and for use in the patients' normal home environment. NeuroLOG will take advantage of the novel algorithms for quantifying wake-sleep transitions that was developed in Phase I. The device will undergo extensive clinical evaluation and validation with normal subjects as well as patients with insomnia. This innovative device will have the potential to significantly improve the management of sleep disorders with insomnia symptoms, as well as a number of psychiatric disorders that are often associated with insomnia, particularly depression. PUBLIC HEALTH RELEVANCE: The device that will be developed in this project (NeuroLOG") will be utilized for assessment of sleep disorders and daytime sleepiness with a particular emphasis on the diagnosis and management of primary insomnia. NeuroLOG will be developed as a wearable (and easily deployable by the patient), fully-automated, and (highly) quantitative analyzer of brain waves and wake-sleep stages for extended night-time sleep, and daytime sleepiness, and for use in the patients' normal home environment. This innovative device will have the potential to significantly improve the management of sleep disorders with insomnia symptoms, as well as a number of psychiatric disorders that are often associated with insomnia, particularly depression.

描述（由申请人提供）：该项目的总体目标是开发一种从根本上改进方法的手段（硬件、算法、电极附件），用于长期监测睡眠结构和质量以及白天嗜睡。该项目将开发的设备（称为“NeuroLOG”）将用于评估睡眠障碍和白天嗜睡，特别强调原发性失眠的诊断和管理。慢性失眠影响着 10-15% 的人。成年人（非收容老年人中的患病率为 57%），另外 25% 至 35% 的成年人患有短暂或偶尔失眠。失眠与严重的个人和社会经济负担有关。该项目的具体目标是将 NeuroLOG 开发为可穿戴（且易于患者部署）、全自动和（高度）定量的大脑分析仪。 NeuroLOG 将利用 Phase 开发的量化唤醒-睡眠转换的新颖算法，以延长夜间睡眠和白天嗜睡，并在患者的正常家庭环境中使用。 I. 该设备将在正常受试者以及失眠患者中进行广泛的临床评估和验证。这种创新设备将有可能显着改善对伴有失眠症状的睡眠障碍以及许多通常与失眠相关的精神疾病（尤其是抑郁症）的治疗。公共健康相关性：该项目将开发的设备（NeuroLOG”）将用于评估睡眠障碍和白天嗜睡，特别强调原发性失眠的诊断和管理。NeuroLOG 将开发为可穿戴（和患者可轻松部署），全自动且（高度）定量的脑电波和觉醒睡眠阶段分析仪，可延长夜间睡眠和白天嗜睡，并可在患者的正常家中使用这种创新设备将有可能显着改善对伴有失眠症状的睡眠障碍以及许多通常与失眠相关的精神疾病（尤其是抑郁症）的治疗。