T Cell responses in Liver Gene therapy

肝脏基因治疗中的 T 细胞反应

• 批准号: 7595327
• 负责人: James M Wilson
• 金额: $ 40.86万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7595327
• 关键词: Abetalipoproteinemia; Address; Adenoviruses; Adoptive Transfer; Affinity; Animal Model; Animals; Antigens; Capsid; Cardiovascular Diseases; Cell Line; Cells; Clinical; Clinical Research; Clinical Trials; Complementary DNA; Cross Presentation; Cytotoxic T-Lymphocytes; DNA Viruses; Data Aggregation; Dependovirus; Disease; Engineering; Engraftment; Epitopes; Evaluation; Familial Hypercholesterolemia; Family; Gagging; Gene Transfer; Generations; HIV; HIV-1; Health Sciences; Hemophilia A; Hepatocyte; Hepatotoxicity; Human; Human Resources; Immune; Immunization; Infection; Injection of therapeutic agent; Last Name; Liver; Low Density Lipoprotein Receptor; MHC Class I Genes; Macaca; Memory; Modeling; Mus; Names; Oregon; Pennsylvania; Population; Primates; Principal Investigator; Printing; Process; Proteins; Registries; Reporter Genes; Research; Research Project Grants; Role; Safety; Series; Stem cells; T memory cell; T-Cell Activation; T-Lymphocyte; T-Lymphocyte Epitopes; Technology; Time; Toxic effect; Transferase; Transgenes; Triglycerides; Universities; Wild Type Mouse; Xenograft procedure; adeno-associated viral vector; base; cellular engineering; gene therapy; human embryonic stem cell; liver xenograft; mature animal; mouse model; nonhuman primate; novel; pre-clinical; preclinical study; programs; reconstitution; research study; response; vector

Use continuation pages as neededto provide the required information in the format shown below. Start with Program Director(s)/Principal Investigator(s). List all other senior/key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Wilson, James M. WILSONJM University of Pennsylvania PI Wang, Lili LILIWANG University of Pennsylvania Co-Pi OTHER SIGNIFICANT CONTRIBUTORS Name Organization Role on Project Riley, James University of Pennsylvania Collaborator Grompe, Marcus Oregon Health & Science University Collaborator Human Embryonic Stem Cells ^ No Q Yes If the proposedproject Involves humanembryonic stem cells, list below the registration number of the specificcell line(s) from the following list: http://stemcells.nih.gov/research/reaistrv/. Usecontinuation pages as needed. If a specific line cannot be referenced at this time, include a statement that one from the Registry will be used. Cell Line PHS 398 (Rev. 11/07) Page t,1 Form Page 2-continued Number the following pages consecutivelythroughout the application. Do not use suffixes such as 4a, 4b, PROJECT I Program Director/Principal Investigator (Last, First, Middle): Wilson, James M. / WilSOH, James M. The name of the program director/principal investigator must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Description, Project/

根据需要使用延续页面以如下所示的格式提供所需信息。 从项目主任/首席研究员开始。按字母顺序列出所有其他高级/关键人员，姓氏在前。 名称 eRA Commons 用户名 项目中的组织角色 Wilson, James M. WILSONJM 宾夕法尼亚大学 PI Wang, Lili LILIWANG 宾夕法尼亚大学 Co-Pi 其他重要贡献者 名称 组织在项目中的角色 赖利，宾夕法尼亚州詹姆斯大学合作者 Grompe，马库斯俄勒冈健康与科学大学合作者 人类胚胎干细胞 ^ 否 Q 是 如果拟议项目涉及人胚胎干细胞，请在下面列出以下列表中特定细胞系的注册号： http://stemcells.nih.gov/research/reaistrv/。根据需要使用连续页面。 如果此时无法引用特定行，请包含一项声明，表明将使用注册表中的某一行。 细胞系 PHS 398（修订版 11/07）第 t,1 页表格第 2 页-续 对接下来的页码进行连续编号 该应用程序。请勿使用 4a、4b、 项目 I 项目总监/首席研究员（最后、第一、中间）：Wilson, James M. / WilSOH, James M. 项目主管/主要研究者的姓名必须提供在每个打印页和每个续页的顶部。 研究资助 目录 页码 描述、项目/