HEART FAILURE MODELING IN RABBIT

兔子心力衰竭模型

• 批准号: 7955267
• 负责人: Alan J Garfinkel
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955267
• 关键词: Binding; Biological Models; Biomedical Computing; Cause of Death; Computer Retrieval of Information on Scientific Projects Database; Diffusion; Equation; Funding; General Population; Grant; Heart; Heart failure; Institution; Modeling; Oryctolagus cuniculus; Reaction; Research; Research Personnel; Resources; Source; Tissues; United States National Institutes of Health; Work; insight; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Heart failure is a leading cause of death in the general population. Rabbit models are important in providing insights into the factors contributing to heart failure. Previous experiments have indicated that: rectilinear waves, governed by reaction-diffusion partial differential equations, can become unstable and break up, even in perfectly homogeneous tissue, due to electrical instabilities. Current work aims to develop better models to describe the molecular interactions using reaction-diffusion PDE's using rabbit heart as the modeling system.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 心力衰竭是普通人群死亡的主要原因。兔子模型对于深入了解导致心力衰竭的因素非常重要。先前的实验表明：由于电不稳定性，即使在完全均匀的组织中，由反应扩散偏微分方程控制的直线波也可能变得不稳定并破裂。目前的工作旨在开发更好的模型来使用反应扩散偏微分方程（使用兔心脏作为建模系统）来描述分子相互作用。