Reducing Susceptibility to Environmental Stress Throughout the Life Span

降低整个生命周期对环境压力的敏感性

• 批准号: 7901764
• 负责人: JOSEPH S BECKMAN
• 金额: $ 71.49万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-03 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7901764
• 关键词: Reducing; Susceptibility; Environmental; Stress; Throughout

DESCRIPTION (provided by applicant) The Environmental Health Sciences (EHS) Center at Oregon State University is an interdisciplinary unit of 35 Center investigators and now in its 39th year of existence. The mission of the EHS Center is to foster excellent research and technology development into the fundamental causes and progression of environmentally related diseases; to advance our ability to predict, prevent, and mitigate environmental insults and promote health; and to disseminate this knowledge to educate the government and public to make informed decisions. The theme for the Oregon State University (OSU) EHS Center is to advance our knowledge concerning the actions of environmental agents at the molecular and cellular level and to understand how we can modulate our individual susceptibility to improve health. To achieve these objectives, the Center continues to develop pioneering analytical capabilities, investigate model systems, and apply the results to realworld problems. The results of this research enabled by the Center contribute to the scientific basis for the prediction of health risks due to exposure to environmental chemicals, aid in the development of innovative approaches for use in risk assessment, and to minimize the impact of environmental stresses on human health. The broad intellectual base of expertise, research, and teaching allows the Center to conduct innovative environmental health-related studies across campus through collaborations and sharing of expertise. Three Research Cores focus collaborative research into the broad themes of: (1) Environmental Mutagenesis and Carcinogenesis, (2) Biomolecular and Environmental Chemistry, and (3) Signaling and Oxidative Stress. Four Facility Cores provide scientists with access to expertise, services, and major equipment in specific research technologies. (1) Aquatic Models, (2) Mass Spectrometry, (3) Cell Imaging and Analysis, and (4) Integrated Human Health Core-newly formed from the Statistics Core and a clinical study coordinator. The EHS Center grant also supports the Administration Core and an expanded Pilot Project Program. Because of Center guideline changes, this Center will be merged with the OSU Marine and Freshwater Biomedical Sciences Center, enabling the largest vertebrate animal studies (with 40,000 trout) on carcinogenesis and cancer prevention in the Aquatic Models Facility Core. New capabilities to conduct large-scale toxicology studies using zebrafish are being developed. BACKGROUND This Center, which is one of the original six NIEHS Centers, is applying for years 39-43. This is a revised application of a competing continuation application. The Center has undergone substantial reorganization because of retirements, and new hires, and, of course, the new Center guidelines. The overall theme remains advancing knowledge concerning the actions of environmental agents at the molecular and cellular level and understanding how we can modulate individual susceptibility to improve health. The Center has three long-range goals: 1) to understand the mechanisms for reducing individual susceptibility; 2) to assess health risks at low exposures (with emphasis on large numbers through their aquatic capabilities; and 3) macromolecular interactions. During the last period of support, the Center members obtained one Program Project grant, a Training grant and a Short-Term Minority Undergraduate Training grant, as well as individual grants. Additionally, two new Center-affiliated Program Project grants and 1 Training grant were awarded. There has been a restructuring from the previous structure of seven Facility Cores to the current four: 1) Aquatic Models; 2) Mass Spectrometry; 3) Cell Imaging and Analysis; and 4) Integrated Human Health Core. The fourth Core is a merger of the original Statistics Core and a clinical study coordinator. A formal Community Outreach and Education Core is not proposed in this application. The Center also has an Administrative Core and a Pilot Project Program. ESSENTIAL CHARACTERISTICS Strategic Vision and Impact on Environmental Health

描述（由申请人提供） 俄勒冈州立大学环境健康科学 (EHS) 中心是一个由 35 名中心研究人员组成的跨学科单位，现已成立 39 年。 EHS中心的使命是促进对环境相关疾病的根本原因和进展的优秀研究和技术开发；提高我们预测、预防和减轻环境损害以及促进健康的能力；并传播这些知识，教育政府和公众做出明智的决策。俄勒冈州立大学 (OSU) EHS 中心的主题是增进我们对分子和细胞水平上环境因素作用的了解，并了解我们如何调节个人易感性以改善健康。为了实现这些目标，该中心继续开发开拓性的分析能力，研究模型系统，并将结果应用于现实世界的问题。该中心支持的这项研究成果为预测因接触环境化学品而造成的健康风险提供了科学依据，有助于开发用于风险评估的创新方法，并最大限度地减少环境压力对人类的影响健康。广泛的专业知识、研究和教学知识基础使该中心能够通过合作和专业知识共享在整个校园内开展与环境健康相关的创新研究。三个研究核心将合作研究重点放在以下广泛主题上：(1) 环境诱变和致癌作用，(2) 生物分子和环境化学，以及 (3) 信号传导和氧化应激。四个设施核心为科学家提供特定研究技术方面的专业知识、服务和主要设备。 (1) 水生模型，(2) 质谱分析，(3) 细胞成像和分析，以及 (4) 综合人类健康核心——由统计核心和临床研究协调员新组建。 EHS 中心拨款还支持管理核心和扩大的试点项目计划。由于中心指南发生变化，该中心将与 OSU 海洋和淡水生物医学科学中心合并，从而在水生模型设施核心中开展关于致癌和癌症预防的最大脊椎动物研究（使用 40,000 条鳟鱼）。 使用斑马鱼进行大规模毒理学研究的新能力正在开发中。 背景 该中心是最初的六个 NIEHS 中心之一，正在申请 39-43 年。这是竞争性继续申请的修订申请。由于退休人员和新员工的加入，当然还有新的中心指导方针，该中心经历了重大重组。总体主题仍然是在分子和细胞水平上推进有关环境因素作用的知识，并了解我们如何调节个体易感性以改善健康。 该中心有三个长期目标：1）了解降低个体易感性的机制； 2）评估低暴露下的健康风险（重点是通过其水生能力进行大量评估；3）大分子相互作用。 在上一期支持期间，中心成员获得了一项计划项目资助、一项培训资助和一项短期少数民族本科生培训资助以及个人资助。 此外，还授予了两项新的中心附属计划项目补助金和一项培训补助金。 设施核心结构由之前的七个设施核心重组为目前的四个：1）水生模型； 2) 质谱分析； 3）细胞成像与分析； 4) 综合人类健康核心。第四个核心是原来的统计核心和临床研究协调员的合并。 本申请中未提出正式的社区外展和教育核心。该中心还有一个行政核心和一个试点项目计划。 基本特征 战略愿景和对环境健康的影响