Interdisciplinary Research in Mental Retardation

精神发育迟滞的跨学科研究

• 批准号: 7931446
• 负责人: WILLIAM J MCILVANE
• 金额: $ 7.5万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7931446
• 关键词: Interdisciplinary; Research; Mental; Retardation

DESCRIPTION (provided by applicant): Fundamental issues both within and beyond biology are how the brain develops and how its interactions with the environment influence behavior. The Developmental Disabilities Research Center (DDRC) at the University of Massachusetts Medical School (UMMS) addresses these issues through wide-ranging programs of research on typical and atypical development, which include biomedical, biobehavioral, behavioral, and social science dimensions. Specific focus areas include developmental neuroscience, genetics of neurodevelopmental disorders, sensory systems and information processing, behavioral and cognitive neuroscience, cognitive psychology and behavior analysis, and social process and policy analysis. The DDRC and its companion University Center for Excellence in Developmental Disabilities (UCEDD) also train professionals for careers in research and service to people with disabilities and their families. Research interests of the UMMS DDRC include (1) understanding biological processes that occur during development of the nervous system; (2) characterizing molecular defects in genetic disorders which affect the nervous system; (3) establishing the genetic basis of neurodevelopmental disorders, along with potentially related neuropsychiatric and neurodegenerative disorders; (4) identifying brain regions and functional systems that may be involved in MRDD; (5) advancing knowledge of fundamental processes involved in learning, perception, language, and cognition; (6) applying the latter knowledge to improve the educational opportunities for persons with MRDD, and (7) understanding social processes and social policy implications relevant to persons with MRDD and their families. This revised application for MRDDRC funding encompasses a number of new interdisciplinary collaborations among UMMS faculty and programs. Four core units are proposed to encourage further collaborations relevant to the missions of the DDRC and NICHD. The core units are: Administration, Neuroscience Integration and Support, Scientific and Technical Information Services, and Clinical and Translational Research Support. Each core unit features equipment, facilities, and/or problem-solving capability, and each gives quality, cost-effective service to numerous PHS-funded projects. The collective operations of the cores will both enhance existing MRDD research, and stimulate new interdisciplinary and translational research in MRDD at UMMS and its affiliated institutions.

描述（由申请人提供）：生物学内外的基本问题是大脑如何发育以及其与环境的相互作用如何影响行为。 马萨诸塞大学医学院 (UMMS) 的发育障碍研究中心 (DDRC) 通过针对典型和非典型发育的广泛研究项目来解决这些问题，其中包括生物医学、生物行为、行为和社会科学维度。 具体重点领域包括发育神经科学、神经发育障碍遗传学、感觉系统和信息处理、行为和认知神经科学、认知心理学和行为分析以及社会过程和政策分析。 DDRC 及其姊妹大学发育障碍卓越中心 (UCEDD) 还培训专业人士从事研究和为残疾人及其家庭提供服务。 UMMS DDRC 的研究兴趣包括（1）了解神经系统发育过程中发生的生物过程； (2) 表征影响神经系统的遗传性疾病的分子缺陷； (3) 建立神经发育障碍以及潜在相关的神经精神和神经退行性疾病的遗传基础； (4) 识别可能与 MRDD 相关的大脑区域和功能系统； (5) 增进对学习、感知、语言和认知等基本过程的了解； (6) 应用后一知识来改善 MRDD 患者的教育机会，以及 (7) 了解与 MRDD 患者及其家人相关的社会进程和社会政策影响。 修订后的 MRDDRC 资金申请涵盖了 UMMS 教师和项目之间的许多新的跨学科合作。 建议设立四个核心单位，以鼓励与 DDRC 和 NICHD 的使命相关的进一步合作。 核心单位是：行政管理、神经科学整合和支持、科学和技术信息服务以及临床和转化研究支持。 每个核心单位都具有设备、设施和/或解决问题的能力，并且每个核心单位都为众多 PHS 资助的项目提供优质、具有成本效益的服务。 核心的集体运作将增强现有的 MRDD 研究，并刺激 UMMS 及其附属机构在 MRDD 领域开展新的跨学科和转化研究。