Chemokines and their receptors in the pathogenesis of tuberculosis

结核病发病机制中的趋化因子及其受体

• 批准号: 7884419
• 负责人: GILLIAN L BEAMER
• 金额: $ 13.07万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7884419
• 关键词: Adoptive Transfer; Anatomy; Antigens; Appointment; Arts; Award; Biology; Biomedical Research; CCL3 gene; CCL4 gene; CCR1 gene; CCR5 gene; Cells; Cessation of life; Chronic; Communicable Diseases; Core Facility; Data; Development Plans; Disease; Doctor of Philosophy; Eligibility Determination; Environment; Event; Faculty; Funding; Generations; Goals; Granuloma; Growth; Immune; Immunity; Immunologics; In Vitro; Infection; Job Application; Joints; Kinetics; Knock-out; Knockout Mice; Licensing; Lung; Lymphocyte; Maintenance; Mediastinal lymph node group; Mediating; Mentors; Migration Assay; Mouse Strains; Mus; Mycobacterium tuberculosis; Ohio; Pathogenesis; Pathology; Play; Positioning Attribute; Predisposition; Production; RANTES; Recording of previous events; Recruitment Activity; Research; Research Personnel; Resistance; Role; Scientist; Site; Source; Structure; Structure of parenchyma of lung; T-Lymphocyte; Testing; Time; Training; Training Programs; Tuberculosis; Universities; Veterinarians; Wild Type Mouse; acquired immunity; base; career development; cell growth; cell motility; cell type; chemokine; chemokine receptor; experience; global health; in vivo; lymph nodes; macrophage; member; microbial; migration; programs; pulmonary granuloma; receptor; receptor structure function; response; success

DESCRIPTION (provided by applicant): THE CANDIDATE: Dr. Gillian Beamer, a licensed veterinarian with board-eligibility in veterinary anatomic pathology, is completing a PhD training program at The Ohio State University (OSU). This K08 MSCDA will support her accelerated transition to scientific independence. THE ENVIRONMENT: OSU's Division of Infectious Diseases and Department of Veterinary Biosciences (VBS) are large, well funded biomedical research centers with faculty, state-of-the-art core facilities and a history of effectively training clinician scientists. THE MENTORS: Dr. Joanne Turner and Dr. Larry Schlesinger are faculty members with joint appointments in the Center for Microbial Interface Biology (CMIB) and VBS. Both mentors are highly experienced in tuberculosis research and both are dedicated to the success of the candidate. THE TRAINING PLAN: The 4-year career development plan will accelerate Dr. Beamer's transition to scientific independence. Upon PhD completion and K08 award, she will be immediately eligible for job application and a highly valued candidate for staff scientist positions. The plan includes a short overlapping period for supervised PhD completion followed by the mentored projects outlined in the research plan. Mentoring will be substantially focused during the first 2 years of the award; in the last 2 years, contact will be maintained at a reduced level to facilitate scientific growth. THE PROPOSAL: Granuloma formation in the lungs is required to control M.tb growth. The mechanisms of cellular recruitment to form granulomas, however, are not fully known. Powerful chemoattractant cytokines (chemokines) and their receptors may play vital roles in granuloma formation and maintenance by orchestrating migration of T cells to sites of infection. In this proposal, we will determine the role of chemokines, immunologic consequences and mechanisms of T cell recruitment to granulomas in response to M.tb lung infection in vivo. Defining essential criteria for M.tb granuloma formation will further our understanding of the requirements for the generation of protective immunity.

描述（由申请人提供）： 候选人：Gillian Beamer 博士是一位拥有兽医解剖病理学委员会资格的执业兽医，正在俄亥俄州立大学 (OSU) 完成博士培训计划。 K08 MSCDA 将支持她加速向科学独立的过渡。环境：俄勒冈州立大学传染病科和兽医生物科学系 (VBS) 是大型、资金充足的生物医学研究中心，拥有师资力量、最先进的核心设施以及有效培训临床科学家的历史。导师：Joanne Turner 博士和 Larry Schlesinger 博士是微生物界面生物学中心 (CMIB) 和 VBS 联合任命的教员。两位导师在结核病研究方面都拥有丰富的经验，并且都致力于帮助候选人取得成功。培训计划： 4 年职业发展计划将加速 Beamer 博士向科学独立的过渡。完成博士学位并获得 K08 奖项后，她将立即有资格申请工作，并成为职员科学家职位的高度重视的候选人。该计划包括一个短暂的重叠期，用于监督博士完成，然后是研究计划中概述的指导项目。指导将在该奖项的前两年得到重点关注；在过去两年中，接触将保持在较低水平，以促进科学发展。建议：肺部肉芽肿的形成是控制结核菌生长所必需的。然而，细胞募集形成肉芽肿的机制尚不完全清楚。强大的趋化细胞因子（趋化因子）及其受体可能通过协调 T 细胞向感染部位的迁移，在肉芽肿的形成和维持中发挥重要作用。在本提案中，我们将确定趋化因子的作用、免疫学后果以及 T 细胞招募到肉芽肿以响应体内结核分枝杆菌肺部感染的机制。定义结核分枝杆菌肉芽肿形成的基本标准将进一步加深我们对产生保护性免疫的要求的理解。