Optical Investigation On Early Keratoconus Detection

早期圆锥角膜检测的光学研究

基本信息

批准号：
7905733
负责人：
Ying-Ling Ann Chen
金额：
$ 21.74万
依托单位：
UNIVERSITY OF TENNESSEE SPACE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7905733
关键词：
Adopted Algorithms Anterior Biometry Cell Density Clinical Clinical Research Clinical Trials Collaborations Collagen Computer-Assisted Diagnosis Computers Cornea Corneal dystrophy Data Defect Detection Devices Diagnostic Disease Disease Progression Early Diagnosis Engineering Environment Eye Goals Human Resources Image Image Analysis Imaging Device Investigation Keratoconus Laser Surgery Lasers Life Measurement Measures Medical Medicine Meridians Methods Modeling Mydriatics Operative Surgical Procedures Optics Outcome Patients Performance Population Predisposition Preventive Medicine Procedures Reporting Research Scanning Science Screening procedure Services Simulate Source Specialist Speed Staging Stimulus Surface System Techniques Telemedicine Testing Time Tissues Ultrasonography Validation Vision Visual Visual Acuity base clinical application cost crosslink design digital experience imaging modality improved instrument novel programs public health relevance quality assurance research and development research clinical testing simulation two-dimensional user-friendly

项目摘要

DESCRIPTION (provided by applicant): A novel method of detection of early-stage keratoconus is proposed and is needed to respond to emerging treatment options for this disease. The ability to stop the progression of this disease at its early stage is highly desired, and this now appears possible. Required for this goal is a method to provide low-cost (below $5,000) and sensitive measurements and detection of early-stage keratoconus for the population of greatest susceptibility. The second stimulus for this research also derives from increased options for corrections of vision defects. Undesired outcomes can result from normally successful laser surgery if corneal material is removed from the eyes of patients with undetected forme fruste keratoconus (FFKC). Alternative detection and diagnostic options of this condition is needed to continue the advance of this vision-improving surgical therapy. This proposed study combines physical and medical sciences to satisfy this need for screening for FFKC and early-stage KC in both clinical and non-clinical applications. A cutting-edge technique of personalized eye modeling will be utilized with contemporary clinical wavefront, topography, and ocular biometry data to provide high-fidelity optical models of FFKC and KC eyes. Using this capability, realistic instrument measurement simulations will guide the optimal design of a low-cost device to approach the high-sensitivity detection. This cost-effective method uses multi-eccentric, multi-meridian, adaptive photorefraction (APR) to observe and measure the double-pass wavefront of the FFKC. A sequence of narrow-band, near-infrared (NIR) LED sources that are imbedded on a 2-dimensional plane will be used with typical commercial multi- frame camera. Low power NIR sources will enable non-mydriatic examination covering the larger scotopic visual zone of patients in a darkened testing environment. Quantitative image analysis will be developed from both the clinically measured and the predicted performance on subjects. Digital registration facilitates computer-aided diagnosis (CADx) and extraction of the image's maximum information content, and it enables telemedicine applications. Together, the proposed optical design and hardware engineering and the auto- analysis features provide a promising device and method that could be utilized to provide a medical service in a very broad range of clinical environments. PUBLIC HEALTH RELEVANCE Collaboration of physical and medical sciences will be achieved to provide a method of detection of early-stage keratoconus. Optical computations will be used in conjunction with clinical patient data to realize the optimal design and quantitative predictions and clinical performance results. The device and analysis method will be low-cost, both user- and subject- friendly and suitable for screening of clinical and larger population subjects.

描述（由申请人提供）：提出了一种检测早期圆锥角膜的新方法，并且需要这种方法来应对该疾病的新兴治疗方案。人们非常希望能够在早期阶段阻止这种疾病的进展，现在看来这是可能的。实现这一目标需要一种方法，为最易受影响的人群提供低成本（低于 5,000 美元）且灵敏的早期圆锥角膜测量和检测。这项研究的第二个刺激因素还来自于矫正视力缺陷的选择的增加。如果从未发现的圆锥形角膜 (FFKC) 患者的眼睛中去除角膜材料，通常成功的激光手术可能会导致不良后果。为了继续推进这种改善视力的手术疗法，需要针对这种情况的替代检测和诊断方案。这项拟议的研究结合了物理和医学科学，以满足临床和非临床应用中 FFKC 和早期 KC 筛查的需求。个性化眼部建模的尖端技术将与当代临床波前、地形和眼部生物测量数据相结合，提供 FFKC 和 KC 眼的高保真光学模型。利用这种功能，真实的仪器测量模拟将指导低成本设备的优化设计，以实现高灵敏度检测。这种经济高效的方法使用多偏心、多子午线、自适应光折射 (APR) 来观察和测量 FFKC 的双通波前。嵌入在二维平面上的一系列窄带近红外 (NIR) LED 光源将与典型的商用多帧相机一起使用。低功率近红外源将能够在黑暗的测试环境中实现免散瞳检查，覆盖患者更大的暗视区域。定量图像分析将根据受试者的临床测量和预测表现进行开发。数字配准有助于计算机辅助诊断 (CADx) 和提取图像的最大信息内容，并支持远程医疗应用。总之，所提出的光学设计和硬件工程以及自动分析功能提供了一种有前途的设备和方法，可用于在非常广泛的临床环境中提供医疗服务。公共卫生相关性将实现物理科学和医学科学的合作，以提供早期圆锥角膜的检测方法。光学计算将与临床患者数据结合使用，以实现优化设计以及定量预测和临床表现结果。该设备和分析方法成本低廉，对用户和受试者均友好，适合临床和较大人群受试者的筛查。