Nutritional Epidemiology of Lower Urinary Tract Symptoms

下尿路症状的营养流行病学

• 批准号: 7934629
• 负责人: Nancy Nairi Maserejian
• 金额: $ 18.8万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7934629
• 关键词: Accounting; Adult; Age; Aging; Alcohol consumption; Area; Ascorbic Acid; Behavior Therapy; Beverages; Boston; Caffeine; Calcium; Carbohydrates; Carbonated Beverages; Carbonates; Carotenoids; Categories; Cholesterol; Cigar; Cigarette; Clinical; Coffee; Cohort Studies; Communities; Community Health; Comorbidity; Confounding Factors (Epidemiology); Data; Data Collection; Data Set; Diabetes Mellitus; Diet; Dietary Assessment; Dietary intake; Diuretics; Dose; Ethnic Origin; Fatty acid glycerol esters; Food; Gender; Health Status; Health Surveys; Heart Diseases; Individual; Intake; Juice; Kidney Diseases; Knowledge; Liquid substance; Literature; Macronutrients Nutrition; Malignant Neoplasms; Manuscripts; Methodology; Micronutrients; Minerals; Modeling; Multivariate Analysis; NIH Program Announcements; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; Nutrient; Obesity; Pharmaceutical Preparations; Pharmacologic Substance; Physical activity; Population Heterogeneity; Prevention; Proteins; Publishing; Quality of life; Race; Relative (related person); Research; Research Design; Risk Factors; Role; Sampling; Smoking; Socioeconomic Status; Sodium; Source; Symptoms; Tea; Time; To specify; Tobacco use; Urinary Incontinence; Urination; Variant; Vitamin A; Woman; Zinc; Zinc deficiency; base; community health study; cost; design; energy balance; follow-up; food consumption; innovation; lifestyle factors; lower urinary tract symptoms; men; modifiable risk; nutritional epidemiology; polyunsaturated fat; population based; primary outcome; prospective; public health relevance; response; saturated fat; secondary outcome; trend; urologic

DESCRIPTION (provided by applicant): This project utilizes dietary data that was collected as part of the Boston Area Community Health (BACH) study to help fill knowledge gaps in the nutritional epidemiology of urogynecologic symptoms in a diverse, random community-based sample. Lower urinary tract symptoms (LUTS), including storage, voiding and post micturition symptoms, are a source of daily bother and burden and profoundly lower the quality of life of millions of adults - over 30 million men and women in the US alone. The once prevailing paradigm that these symptoms are an inevitable aspect of aging, unaffected by modification of lifestyle choices, must be challenged, and this study responds to nation-wide calls for research to identify risk factors for these symptoms. One of the most readily modifiable lifestyle factors that holds highly plausible mechanisms of offering relief and prevention, as well as being involved in the initiation and progression, of LUTS is diet - i.e., the nutrients and beverages consumed daily. This study examines the cross-sectional and longitudinal associations between intakes of carbohydrate, protein, types of fat, sodium, cholesterol, vitamin C, vitamin A, carotenoids, calcium and zinc, and LUTS, voiding symptoms, post micturition symptoms, and storage symptoms, including urgency and urinary incontinence, separately in men and women. It also examines dietary versus supplemental sources of micronutrients and dose-response trends across categories of intake. Intakes of various beverage types are also examined prospectively to verify anecdotal evidence regarding effects of caffeine, acidic or carbonated beverages. BACH obtained a complete validated dietary assessment that takes into account ethnic variation in food consumption, which, together with in-depth data on urologic symptoms, sociodemographics, anthropometrics, health status, medication and supplement usage, provides a unique cost-efficient opportunity to conduct multivariate analyses of the role of nutrients and beverages in urologic symptoms among men and women. PUBLIC HEALTH RELEVANCE: 7. PROJECT NARRATIVE This study will investigate the associations between intakes of macronutrients, micronutrients, fluids and lower urinary tract symptoms in a diverse, population-based sample of men and women using both cross- sectional and prospective cohort study design methodologies. Lower urinary tract symptoms will be examined both overall and also grouped as storage symptoms, including urgency and urinary incontinence, voiding symptoms, and post micturition symptoms.

描述（由申请人提供）：该项目利用作为波士顿地区社区健康 (BACH) 研究的一部分收集的饮食数据，以帮助填补基于社区的多样化随机样本中泌尿妇科症状营养流行病学的知识空白。下尿路症状 (LUTS)，包括储尿、排尿和排尿后症状，是日常困扰和负担的根源，并严重降低了数百万成年人的生活质量——仅在美国就有超过 3000 万男性和女性。曾经盛行的观念认为，这些症状是衰老过程中不可避免的一个方面，不受生活方式选择改变的影响，这一观念必须受到挑战，这项研究响应了全国范围内要求开展研究以确定这些症状的危险因素的呼吁。最容易改变的生活方式因素之一是饮食，即每天摄入的营养物质和饮料，它具有提供缓解和预防以及参与 LUTS 的发生和进展的高度可信的机制。本研究考察了碳水化合物、蛋白质、脂肪类型、钠、胆固醇、维生素 C、维生素 A、类胡萝卜素、钙和锌以及 LUTS 摄入量、排尿症状、排尿后症状和储尿症状之间的横向和纵向关联，包括男性和女性的尿急和尿失禁。它还检查了微量营养素的膳食来源与补充来源以及不同摄入类别的剂量反应趋势。还前瞻性地检查了各种饮料类型的摄入量，以验证有关咖啡因、酸性或碳酸饮料影响的轶事证据。巴赫获得了完整的经过验证的饮食评估，该评估考虑了食物消费的种族差异，再加上泌尿系统症状、社会人口统计学、人体测量学、健康状况、药物和补充剂使用的深入数据，提供了一个独特的、具有成本效益的机会来进行对营养素和饮料在男性和女性泌尿系统症状中的作用进行多变量分析。公共卫生相关性： 7. 项目叙述 本研究将使用横断面和前瞻性队列研究设计方法，在不同人群的男性和女性样本中调查大量营养素、微量营养素、液体摄入量与下尿路症状之间的关联。下尿路症状将进行整体检查，也可分为储存症状，包括尿急和尿失禁、排尿症状和排尿后症状。