BONE DENSITY IN CHILDHOOD STUDY - CLINICAL CENTER

儿童骨密度研究 - 临床中心

• 批准号: 7891903
• 负责人: Margaret M Frederick
• 金额: $ 99.14万
• 依托单位: CLINICAL TRIALS AND SURVEYS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7891903
• 关键词: BONE; DENSITY; CHILDHOOD; STUDY; CLINICAL

The purpose of the bone mineral density in childhood study (BMDCS) is to obtain standard reference bone mineral density measures taking into consideration skeletal maturation, bone size and volume, body size, and pubertal stage. These data will serve as an extremely valuable standard pediatric BMD database. It is anticipated to become the essential reference that will enable pediatricians to study, diagnose, and treat children with disorders affecting bone accrual. The six contracts for the Clinical Centers and the Data Coordinating Center were awarded on August 1, 2001. The five academic clinical centers all adhere to a common longitudinal observational protocol involving a baseline and three consecutive annual evaluations, including dual x-ray absorptiometry (DXA) and bone age x-ray, a physical exam to determine their pubertal status, stadiometer height, weight, and body mass index (BMI). Additionally, three sites are performing CT or pQCT scans on a subset of children. Information relating to bone health such as diet and exercise is obtained from each child annually. The bone age x-ray and DXA scans are interpreted centrally. Recruitment commenced in July 2002 at five Clinical Centers and resulted in the enrollment by November 1, 2003 of 1554 children from 6-16 years old of both genders and all racial groups.

儿童骨矿物质密度研究 (BMDCS) 的目的是获得考虑骨骼成熟度、骨骼大小和体积、身体尺寸和青春期阶段的标准参考骨矿物质密度测量值。这些数据将作为极其有价值的标准儿科 BMD 数据库。预计它将成为儿科医生研究、诊断和治疗患有影响骨生成疾病的儿童的重要参考资料。临床中心和数据协调中心的六份合同于 2001 年 8 月 1 日授予。五个学术临床中心都遵守共同的纵向观察协议，涉及基线和连续三年的年度评估，包括双 X 射线吸收测定法 (DXA) ）和骨龄 X 光检查，这是一项身体检查，以确定青春期状态、身高计身高、体重和体重指数 (BMI)。此外，三个站点正在对部分儿童进行 CT 或 pQCT 扫描。每年从每个孩子那里获得与骨骼健康有关的信息，例如饮食和锻炼。集中解读骨龄 X 射线和 DXA 扫描。招募工作于 2002 年 7 月在五个临床中心开始，截至 2003 年 11 月 1 日，共有 1 554 名 6 至 16 岁的儿童入组，其中包括性别和种族群体。