Tissue Based Small Animal Model for HIV Drug Discovery

用于 HIV 药物发现的基于组织的小动物模型

• 批准号: 7789059
• 负责人: Cheryl Stoddart
• 金额: $ 16.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-06 至 2013-12-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7789059
• 关键词: Tissue; Based; Small; Animal; Model

The objective of this contract is to further the preclinical development of novel therapies (low molecular weigh organic molecules, biologics, and engineered viruses) for HIV- 1 through pre-clinical testing in the well characterized SCID-hu Thy/Liv modle small animal model. The major scientific functions of this contract are listed below: 1. Evaluate HIV therapeutics in an in vitro model 2. Evaluate potential HIV-1 therapeutics in vivo in a validated small-animal model 3. Maintain quality control/assurance of viral stocks, donor tissue, and reconstituted immunodeficient mice 4. Further characterize or develop the animal model and adapt newly discovered models 5. Collect samples of animal tissues and/or fluids and prepare such samples for shipment

该合同的目的是通过在充分表征的 SCID-hu Thy/Liv 模型小动物模型中进行临床前测试，进一步推进 HIV-1 新型疗法（低分子量有机分子、生物制剂和工程病毒）的临床前开发。 该合约的主要科学功能如下： 1. 在体外模型中评估 HIV 疗法 2. 在经过验证的小动物模型中评估潜在的 HIV-1 体内疗法 3. 维持病毒库存、供体组织和重组免疫缺陷小鼠的质量控制/保证 4. 进一步表征或开发动物模型并适应新发现的模型 5. 收集动物组织和/或体液样本并准备用于运输的样本