T and B Cell Collaboration in Germinal Centers and Beyond

T 细胞和 B 细胞在生发中心及其他区域的合作

• 批准号: 10753621
• 负责人: TERRY L. SHEPPARD
• 金额: $ 0.55万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753621
• 关键词: 2019-nCoV; Address; Antibodies; Area; Autoimmune Diseases; B-Lymphocytes; British Columbia; COVID-19 pandemic; COVID-19 vaccine; Canada; Cell Communication; Cells; Collaborations; Communicable Diseases; Creativeness; Data; Development; Disease; Educational workshop; Fostering; Future; Health; Human; Immune response; Immune system; Immunity; Immunologic Memory; Immunologics; Infection; Joints; Knowledge; Learning; Malignant Neoplasms; Mentors; Methodology; Modeling; Outcome; Persons; RNA vaccination; Research; Research Personnel; Research Priority; Science; Scientist; Structure of germinal center of lymph node; T-Lymphocyte; Technology; Therapeutic; Vaccines; Variant; Viral; clinical practice; combat; design; improved; interest; multidisciplinary; posters; prospective; response; symposium; tertiary lymphoid organ

ABSTRACT Support is requested for a Keystone Symposia conference entitled T and B Cell Collaboration in Germinal Centers and Beyond, organized by Drs. Shane Crotty, Michela Locci and Jennifer Gommerman. The conference will be held in Whistler, British Columbia, Canada from October 1-4, 2023. T cell/B cell interactions are fundamental for numerous immune responses. And, as the COVID-19 pandemic demonstrated, the successful development of COVID-19 vaccines highlighted the extreme value of T and B cell interactions for protective immunity. For example, the development of antibodies able to neutralize variants as diverse as Omicron, after not one or two but after three other mRNA immunizations, with the same ancestral SARS-CoV-2 Spike, is a dramatic example of the importance of germinal centers in protective immunity, and the brilliance of the immune system in rapidly evolving T-dependent B cell responses capable of neutralizing extreme viral variants the cells never previously encountered in the germinal centers. However, there remains much to be learned about the critical importance of T cell/B cell interactions and germinal centers for vaccines and infectious diseases. Furthermore, the relevance of these immunological interactions is much broader in biomedicine. T cell/B cell interactions are important in many autoimmune diseases. Moreover, this conference will be held jointly with the Keystone Symposium on B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics and there will be joint sessions covering T cell/B cell interactions in cancer.

抽象的 请求支持题为“生发中 T 细胞和 B 细胞合作”的 Keystone 研讨会 中心及其他，由博士组织。肖恩·克罗蒂、米凯拉·洛奇和詹妮弗·戈默曼。会议 将于2023年10月1日至4日在加拿大不列颠哥伦比亚省惠斯勒举行。 T 细胞/B 细胞相互作用是许多免疫反应的基础。而且，随着 COVID-19 大流行 事实证明，COVID-19疫苗的成功研发凸显了T细胞和B细胞的极端价值 保护性免疫的相互作用。例如，开发能够中和变体的抗体 与 Omicron 不同，不是一两次，而是三次其他 mRNA 免疫接种后，具有相同的祖先 SARS-CoV-2 Spike 是生发中心在保护性免疫中重要性的一个生动例子， 免疫系统在快速进化的 T 依赖性 B 细胞反应中表现出色，能够中和极端的 细胞以前在生发中心从未遇到过的病毒变体。然而，还有很多工作要做 了解 T 细胞/B 细胞相互作用和疫苗生发中心的至关重要性 传染病。此外，这些免疫相互作用的相关性在以下方面更为广泛： 生物医学。 T 细胞/B 细胞相互作用在许多自身免疫性疾病中很重要。此外，本次大会 将与 B 细胞和三级淋巴结构：新兴目标 Keystone 研讨会联合举办 癌症治疗学，并将举办涵盖癌症中 T 细胞/B 细胞相互作用的联合会议。