Vitamin D and Susceptibility to Inhaled Pollutants in Urban Children with Asthma

城市哮喘儿童维生素 D 与吸入污染物的易感性

基本信息

批准号：
8003019
负责人：
Sonali Bose
金额：
$ 5.96万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8003019
关键词：
Accounting Affect African American Age Air Pollution Allergens Antioxidants Asthma Attention Baltimore Biological Markers Blood Breathing Child Childhood Childhood Asthma Clinical Clinical Research Cross-Sectional Studies Diet Dietary intake Disadvantaged Disease Economics Environment Environmental Pollutants Epidemiologic Studies Exposure to Extrinsic asthma Future Goals Grant Health Immune Inflammation Inflammatory Response Investigation Lead Lung Inflammation Measures Mentorship Minority Monitor Morbidity - disease rate Nasal Lavage Fluid Oxidative Stress Particulate Matter Pharmaceutical Preparations Population Poverty Predisposition Preparation Public Health Recruitment Activity Research Research Proposals Respiratory physiology Risk Role Seasons Serum Skin Sun Exposure Symptoms Training United States Urine Vitamin D Vulnerable Populations burden of illness cost environmental particulate experience improved inner city novel pollutant protective effect public health relevance skills social

项目摘要

DESCRIPTION (provided by applicant): The proposed project promises to be a rich training experience that will allow me to develop the skills necessary for clinical research. It achieves this through a combination of a rigorous research plan, relevant coursework, and supervised dedicated mentorship. Below is a summary of the research proposal. The urban minority pediatric population in the United States has a disproportionate burden of asthma. Several factors may contribute to this disparity, including high exposure to environmental pollutants and allergens, a poor diet, and other disadvantages of poverty. Recent attention has focused on the antioxidant and immune-modulatory role of vitamin D which may confer a protective effect on disease morbidity, and several clinical observational and cross-sectional studies support that low vitamin D levels may lead to greater allergic and asthma manifestations. Epidemiological studies, including our own preliminary investigations in Baltimore, have discovered that a significant proportion of African-American inner-city children with asthma have well below the recommended levels of serum vitamin D, and that, in these same children, indoor particulate matter (PM) is a significant cause of asthma morbidity. We therefore propose to determine whether lowerlevels of vitamin D, in such a highly-affected and vulnerable population, may increase their susceptibility to inhaled pollutants. To achieve this goal, we will nest this proposed study within an existing grant (The Center for Childhood Asthma in the Urban Environment DISCOVER # 1P50ES015903), which is currently recruiting 130 predominantly-black children with asthma, ages 5-12 years, in urban Baltimore to study the mechanisms by which air pollution induces lung inflammation and oxidative stress. This project proposal has three novel aims. First, to better understand the relationship between vitamin D levels and asthma health, we will be repeatedly measuring each subject' s serum vitamin D levels, daily asthma symptoms and medication use, and twice-daily lung function during 4 one-week periods in each season of the year. Second, to determine if varying levels of vitamin D modify the inflammatory response to air pollution, we will also be monitoring each child' s personal exposure to environmental PM throughout the day and simultaneously be measuring biomarkers of oxidative stress and inflammation present in blood, urine, and nasal lavage fluid. Finally, we will be collecting information regarding sun exposure, skin type, and dietary intake in order to assess the determinants of vitamin D status in this chronically low population, in preparation for future public health strategies directed towards improving asthma health. PUBLIC HEALTH RELEVANCE: Asthma attacks are particularly severe among urban African-American children and account for significant personal, economic, and social costs. Recent studies show that the majority of these children have low blood levels of vitamin D, and that the lower their levels, the worse their asthma symptoms seem to be. We would like to understand if low vitamin D levels put children at increased risk to be affected by common environmental triggers; if true, then improving their vitamin D status may ultimately protect urban minority children from a high burden of disease.

描述（由申请人提供）：拟议的项目有望提供丰富的培训经验，使我能够培养临床研究所需的技能。它通过严格的研究计划、相关课程和有监督的专门指导相结合来实现这一目标。以下是研究计划的摘要。美国城市少数儿童人口的哮喘负担不成比例。有几个因素可能造成这种差异，包括大量接触环境污染物和过敏原、不良饮食以及贫困的其他缺点。最近的注意力集中在维生素 D 的抗氧化和免疫调节作用上，它可能对疾病发病率具有保护作用，并且一些临床观察和横断面研究支持低维生素 D 水平可能导致更严重的过敏和哮喘表现。流行病学研究（包括我们在巴尔的摩进行的初步调查）发现，很大一部分患有哮喘的非裔美国市中心儿童的血清维生素 D 水平远低于推荐水平，而且在这些儿童中，室内颗粒物（ PM）是哮喘发病的重要原因。因此，我们建议确定在如此严重受影响和脆弱的人群中，较低水平的维生素 D 是否会增加他们对吸入污染物的易感性。为了实现这一目标，我们将把这项拟议的研究纳入一项现有拨款（城市环境中儿童哮喘中心发现＃1P50ES015903），该拨款目前正在城市招募 130 名年龄为 5-12 岁、以黑人为主的哮喘儿童。巴尔的摩研究空气污染诱发肺部炎症和氧化应激的机制。该项目提案具有三个新颖的目标。首先，为了更好地了解维生素 D 水平与哮喘健康之间的关系，我们将在每个受试者的 4 个为期一周的时间段内重复测量每个受试者的血清维生素 D 水平、每日哮喘症状和药物使用情况以及每日两次肺功能。一年中的季节。其次，为了确定不同水平的维生素 D 是否会改变对空气污染的炎症反应，我们还将监测每个孩子全天接触环境 PM 的情况，同时测量血液、尿液中存在的氧化应激和炎症的生物标志物和鼻腔冲洗液。最后，我们将收集有关阳光照射、皮肤类型和饮食摄入量的信息，以评估这一长期偏低人群中维生素 D 状况的决定因素，为未来旨在改善哮喘健康的公共卫生策略做好准备。公共卫生相关性：哮喘发作在城市非裔美国儿童中尤为严重，造成巨大的个人、经济和社会损失。最近的研究表明，这些儿童中的大多数血液中维生素 D 水平较低，而且维生素 D 水平越低，他们的哮喘症状似乎越严重。我们想了解维生素 D 水平低是否会增加儿童受常见环境触发因素影响的风险；如果属实，那么改善他们的维生素 D 状况可能最终可以保护城市少数民族儿童免受沉重的疾病负担。