Simulation of Coronary Artery Bypass Graft and Surgical Ventricular Restoration

冠状动脉搭桥术和心室修复手术的模拟

基本信息

批准号：
7915279
负责人：
Julius Matteo Guccione
金额：
$ 76.23万
依托单位：
NORTHERN CALIFORNIA INSTITUTE/RES/EDU
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-15 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7915279
关键词：
3-Dimensional Accounting Address Adopted Adult Affect Algorithms Anatomic structures Anatomy Anterior Descending Coronary Artery Aorta Architecture Area Arteries Automobile Driving Awareness Biological Biology Biomechanics Biomedical Computing Biomedical Engineering Biomedical Research Biophysics Blood Vessels Blood capillaries Blood flow Bypass Cardiac Cardiac Surgery procedures Cardiovascular system Cells Cereals Cerebral Palsy Cessation of life Chemicals Child Code Collaborations Collection Communities Complement Computer Assisted Computer Simulation Computer software Computer-Aided Design Copyright Coronary Coronary Arteriosclerosis Coronary Artery Bypass Coronary artery Custom Data Data Analyses Data Set Databases Development Device Designs Discipline Disease Doctor of Medicine Documentation Drug Delivery Systems Dyskinetic syndrome Electrophysiology (science)Electrostatics Elements Engineering Ensure Environment Epidemic Equation Evaluation Fiber Figs - dietary Future Generations Genetic Medicine Goals Grant Heart Heart failure Human Image Imagery Indiana Individual Infarction Intervention Investigation Laboratories Language Lead Left Left Ventricular Function Left Ventricular Remodeling Letters Libraries Licensing Life Link Liquid substance Location Logic Magnetic Resonance Imaging Mathematics Mechanics Medical Medical Device Medical Research Medical center Methodology Methods Mission Modeling Modification Molecular Motion Movement Muscle Muscle Cells Myocardial Myocardial Ischemia Myopathy Myosin ATPase National Center for Research Resources Nature Newsletter Nonmuscle Myosin Type IIB Operative Surgical Procedures Organ Organism Paper Parkinson Disease Patient Care Patients Pattern Performance Persons Pharmaceutical Preparations Philosophy Physics Physiological Physiology Postoperative Period Problem Solving Procedures Process Prosthesis Design Public Domains RNA RNA Folding Randomized Research Research Infrastructure Research Personnel Resources Running Scientist Selection Criteria Simulate Software Engineering Software Tools Solid Solutions Source Source Code Stroke Structure Surgeon System Techniques Technology Technology Transfer Testing Time Tissues Training Trees United States United States National Institutes of Health Universities Validation Vascular Diseases Vascular System Ventricular Work advanced simulation base biological systems biomedical scientist body system capillary commercialization computer science computerized tools data modeling design disease diagnosis dissemination research effective therapy fluid flow graduate student graphical user interface hemodynamics image visualization improved innovation interest left coronary artery macromolecule mathematical model member meter millimeter models and simulation nanometer neuromuscular novel novel strategies open source palliation patient population physical property pressure programs randomized trial repository response restoration shear stress simulation software development tool tool development

项目摘要

Heart failure has reached epidemic proportions in the United States and is responsible for nearly 500,000 deaths each year. The majority of heart failure cases is now the result of infarction- induced left ventricular (LV) remodeling. The lack of a well-established effective treatment has lead to a continually expanding list of medical and surgical options for the palliation of heart failure patients. Coronary artery bypass grafting (CABG) and surgical ventricular restoration (SVR) are the two surgical options included in the ongoing $38 million NIH-sponsored multi- center randomized STICH trial (to be completed in 2008). Another recently completed randomized trial has shown for the first time a benefit of CABG + SVR over CABG alone in patients with heart failure caused by coronary artery disease. Moreover, it confirms that the SVR procedure can be performed safely in patients with severely reduced LV function. Broad, Long-Term Objective: Develop and validate a public-domain software tool that will enable clinicians to easily simulate the effects of CABG and SVR on patients with ischemic heart failure. Specific Aims: 1. Develop physics-based simulations of CABG and SVR using only public-domain software. 2. Perform pre- and post-operative CT and MRI exams on STICH patients in order to quantify their LV wall geometry and function and coronary artery anatomy and blood flow distribution. 3. Validate the simulations in Aim #1 using the LV function and coronary blood flow data acquired in Aim #2. In addition, as part of a repository for wide dissemination to the user community, CABG and SVR models will be made available via the simulation tool kit (SimTK) of Stanford's National Center for Physics-Based Simulation of Biological Structures (Simbios). These models and tools will complement work that is ongoing as part of one of the Simbios driving biological problems lead by Dr. Charley Taylor that focuses on blood flow and grafts in the aorta, and will provide a larger repertoire of fluid flow modeling capabilities in SimTK.

心力衰竭在美国已达到流行病的程度，每年导致近 50 万人死亡。现在大多数心力衰竭病例是梗塞引起的左心室（LV）重构的结果。由于缺乏完善的有效治疗方法，导致心力衰竭患者姑息治疗的医疗和手术选择不断增加。冠状动脉旁路移植术 (CABG) 和心室修复术 (SVR) 是 NIH 资助的 3800 万美元正在进行的多中心随机 STICH 试验（将于 2008 年完成）中包含的两种手术选择。最近完成的另一项随机试验首次表明，对于冠状动脉疾病引起的心力衰竭患者，CABG + SVR 比单独 CABG 更有益处。此外，它证实了 SVR 手术可以在左心室功能严重降低的患者中安全地进行。广泛的长期目标：开发并验证一个公共领域的软件工具，使临床医生能够轻松模拟 CABG 和 SVR 对缺血性心力衰竭患者的影响。具体目标： 1. 仅使用公共领域软件开发基于物理的 CABG 和 SVR 模拟。 2. 对 STICH 患者进行术前和术后 CT 和 MRI 检查，以量化其左室壁几何形状和功能以及冠状动脉解剖和血流分布。 3. 使用目标 #2 中获取的 LV 函数和冠状动脉血流数据验证目标 #1 中的模拟。此外，作为向用户社区广泛传播的存储库的一部分，CABG 和 SVR 模型将通过斯坦福大学国家生物结构物理模拟中心 (Simbios) 的模拟工具包 (SimTK) 提供。这些模型和工具将补充由 Charley Taylor 博士领导的 Simbios 驱动生物问题之一正在进行的工作，该工作重点关注主动脉中的血流和移植物，并将在 SimTK 中提供更大的流体流动建模功能。。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.

个性化计算心脏病学：心肌梗死的心脏力学和生物材料注射疗法中的患者特异性建模。

DOI：
发表时间：
2016-11
期刊：
影响因子：
4.6
作者：
Sack, Kevin L;Davies, Neil H;Guccione, Julius M;Franz, Thomas
通讯作者：
Franz, Thomas

Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery.

冠状动脉搭桥手术的患者特异性血流多尺度建模。

DOI：
发表时间：
2012-10
期刊：
影响因子：
3.8
作者：
Sankaran, Sethuraman;Esmaily Moghadam, Mahdi;Kahn, Andrew M;Tseng, Elaine E;Guccione, Julius M;Marsden, Alison L
通讯作者：
Marsden, Alison L

Reduction in left ventricular wall stress and improvement in function in failing hearts using Algisyl-LVR.

使用 Algisyl-LVR 减少左心室壁应力并改善衰竭心脏的功能。

DOI：
发表时间：
2013-04-08
期刊：
影响因子：
0
作者：
Lee, Lik Chuan;Zhihong, Zhang;Hinson, Andrew;Guccione, Julius M
通讯作者：
Guccione, Julius M

Mild anastomotic stenosis in patient-specific CABG model may enhance graft patency: a new hypothesis.

患者特异性 CABG 模型中的轻度吻合口狭窄可能会增强移植物通畅：一个新假设。

DOI：
发表时间：
2013
期刊：
影响因子：
3.7
作者：
Huo, Yunlong;Luo, Tong;Guccione, Julius M;Teague, Shawn D;Tan, Wenchang;Navia, José A;Kassab, Ghassan S
通讯作者：
Kassab, Ghassan S

Biaxial vasoactivity of porcine coronary artery.

猪冠状动脉的双轴血管活性。