Plasma Exchange and Glucocorticoids in ANCA Associated Vasculitis: A Randomised Controlled Trial (PEXIVAS Australia)

血浆置换和糖皮质激素治疗 ANCA 相关血管炎：随机对照试验（PEXIVAS 澳大利亚）

• 批准号: nhmrc : 626939
• 负责人: Dr Chen Au Peh
• 金额: $ 42.36万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/plasma-exchange-glucocorticoids-pexivas-australia/78362
• 关键词: Plasma; Exchange; Glucocorticoids; ANCA; Associated

Vasculitis is a life-threatening disease, and the current treatment for this condition is not satisfactory. This clinical trial aims to determine 1) if plasma exchange can lower mortality and the development of severe kidney failure due to this disease, and 2) if the use of lower doses of corticosteroids can lessen the infectious complications of treatment. This trial is part of a major international effort which will involve a total of 500 patients from Australia, UK, Europe, USA and NZ.

血管炎是一种危及生命的疾病，目前对该病的治疗并不令人满意。该临床试验旨在确定 1) 血浆置换是否可以降低死亡率和因这种疾病导致的严重肾衰竭的发生，以及 2) 使用较低剂量的皮质类固醇是否可以减少治疗的感染性并发症。该试验是一项重大国际努力的一部分，将涉及来自澳大利亚、英国、欧洲、美国和新西兰的总共 500 名患者。