Maternal vitamin D, adiposity in early life, and risk of childhood asthma.

母亲维生素 D、生命早期肥胖以及儿童哮喘风险。

基本信息

批准号：
7790669
负责人：
MATTHEW W GILLMAN
金额：
$ 78.44万
依托单位：
HARVARD PILGRIM HEALTH CARE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-15 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7790669
关键词：
25-hydroxycholecalciferol-24-hydroxylase 3 year old 4 year old 7 year old Address Adult Affect Age Age-Months Allergic Asthma Birth Blood Body mass index Bronchodilator Agents Calcifediol Candidate Disease Gene Child Childhood Childhood Asthma Chronic Disease Clinical Investigator Cohort Studies Collaborations Country Data Data Analyses Developed Countries Development Diagnosis Diet Dietary Factors Disease Economics Ensure Epidemiologist Epidemiology Family Fetal Growth Figs - dietary Funding Genes Genetic Genetic Polymorphism Goals Granulocyte-Macrophage Colony-Stimulating Factor Growth Healthcare Hypersensitivity IgE Infant Intake Interdisciplinary Study Interferons Interleukin-10 Interleukin-12 Interleukin-2 Interleukin-4 Lead Length Letters Life Life Style Longitudinal Studies Managed Care Measurement Measures Metabolism Mixed Function Oxygenases Modeling Mothers New England Nursery Schools Nutrient Nutritional Nutritional status Obesity Outcome Outcome Measure Participant Pathway interactions Phenotype Plasma Pregnancy Pregnant Women Prevalence Process Prospective Studies Public Health Publishing Relative (related person)Reporting Research Research Design Resources Risk Signal Transduction Skinfold Thickness Spirometry Sum Sun Exposure Symptoms TNF gene Umbilical Cord Blood Umbilical cord structure Update Vitamin D Vitamin D-Binding Protein Weight Weight Gain Wheezing Work airway obstruction asthma prevention clinically relevant cohort early childhood experience feeding fetal fetal blood follow-up high risk immune function infancy member offspring prenatal prospective psychologic respiratory social sound

项目摘要

DESCRIPTION (provided by applicant): Asthma is the most common chronic disease of childhood in the developed world, and its prevalence in Western industrialized countries is increasing at an alarming rate. Maternal diet during pregnancy represents an important exposure with significant potential to modify immune function in offspring and hence the development of asthma and related atopic disorders in childhood. In addition, fetal growth may be a marker of prenatal processes that have large impact on asthma risk. Fetal growth is now known to be an indicator for risk of other chronic diseases, but the data regarding asthma are remarkably sparse. The goals of this application are to examine the potential impact of maternal dietary factors during pregnancy on the development of asthma and related disorders in early childhood, and to clarify the relationship between size at birth and incident asthma. A longitudinal prospective study is the most appropriate study design to evaluate these goals. This application takes advantage of the resources provided by Project Viva, an ongoing prospective cohort study of pregnant women and their infant offspring among members of Harvard Pilgrim Health Care, a large managed care organization in New England. Data already available from Project Viva include detailed dietary data on mother and infant, along with data on anthropometric, social, environmental, demographic, economic, psychological, and lifestyle variables. By following the Project Viva cohort until the ages of 3-4 years, the current application provides a relatively economical way to obtain updated exposure and outcome data and to answer scientific questions of major public health importance. This work also brings together a multidisciplinary research team with a proven track record of collaboration and expertise in nutritional, respiratory, and pediatric epidemiology.

描述（申请人提供）：哮喘是发达国家最常见的儿童慢性疾病，其在西方工业化国家的患病率正以惊人的速度增加。怀孕期间的母亲饮食是一种重要的暴露，具有改变后代免疫功能的巨大潜力，从而导致儿童时期哮喘和相关特应性疾病的发展。此外，胎儿生长可能是对哮喘风险有很大影响的产前过程的标志。现在已知胎儿生长是其他慢性疾病风险的指标，但有关哮喘的数据却非常少。该应用的目的是检查怀孕期间母亲饮食因素对儿童早期哮喘和相关疾病发展的潜在影响，并阐明出生时体型与哮喘发生之间的关系。纵向前瞻性研究是评估这些目标的最合适的研究设计。该应用程序利用了 Project Viva 提供的资源，该项目是一项正在进行的前瞻性队列研究，对象是哈佛 Pilgrim 医疗保健（新英格兰一家大型管理医疗组织）成员中的孕妇及其婴儿后代。 Viva 项目已经提供的数据包括母亲和婴儿的详细饮食数据，以及人体测量、社会、环境、人口、经济、心理和生活方式变量的数据。通过跟踪 Project Viva 队列直至 3-4 岁，当前的应用程序提供了一种相对经济的方式来获取更新的暴露和结果数据，并回答具有重大公共卫生重要性的科学问题。这项工作还汇集了一个多学科研究团队，他们在营养、呼吸和儿科流行病学方面拥有良好的合作记录和专业知识。