A role for hypothalamic dopamine in predicting homeostatic need

下丘脑多巴胺在预测稳态需求中的作用

• 批准号: 10603506
• 负责人: Michael Schaid
• 金额: $ 6.95万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10603506
• 关键词: Area; Association Learning; Axon; Behavior; Brain; Calories; Characteristics; Communication; Consumption; Cues; Dangerousness; Development; Dissociation; Dopamine; Eating; Eating Disorders; Ensure; Excision; Feeding behaviors; Fiber; Food; Future; Gymnema sylvestre Gurmarin protein; Homeostasis; Hunger; Hypothalamic structure; Lateral Hypothalamic Area; Learning; Mus; Neuroanatomy; Nucleus Accumbens; Obesity; Organism; Pattern; Photometry; Play; Process; Reporting; Rewards; Role; Route; Sensory; Signal Transduction; Source; Structure of nucleus infundibularis hypothalami; Sucrose; Taste Perception; Testing; Training; Ventral Tegmental Area; Work; detector; dopaminergic neuron; experimental study; feeding; food consumption; hedonic; in vivo; inhibitor; neural circuit; novel; pleasure; response; sweet taste perception

PROJECT SUMMARY In order to efficiently control energy homeostasis, the brain makes predictions about future caloric needs and food availability in order to invigorate food-seeking behavior. It is well established that dopamine neurons play a crucial role in this process, as they communicate prediction error signals to central reward centers, such as the nucleus accumbens. This process reinforces learning and aids in the development of reward-seeking behavior in response to environmental cues. Dopamine release in the lateral hypothalamic area (LHA) - a primary homeostatic control center, has been reported. However, it is unknown if dopamine in LHA encodes prediction errors to guide food-seeking behavior. Further, the source of LHA dopamine is currently unknown. In this proposal we aim to characterize the role of dopamine in LHA and test the hypothesis that LHA receives prediction error signals from dopamine neurons in the ventral tegmental area. The experiments in this proposal will reveal a novel neural circuit and define a new role for dopamine in feeding behavior.

项目概要 为了有效地控制能量稳态，大脑会对未来做出预测 热量需求和食物供应，以激发觅食行为。很好 确定多巴胺神经元在这一过程中发挥着至关重要的作用，因为它们进行交流 预测误差向中央奖励中心（例如伏核）发出信号。这个过程 加强学习并帮助发展寻求奖励的行为以应对 环境线索。下丘脑外侧区 (LHA) 的多巴胺释放 - 主要 稳态控制中心，已有报道。然而，LHA 中的多巴胺是否存在尚不清楚。 对预测错误进行编码以指导寻找食物的行为。此外，LHA多巴胺的来源 目前未知。在本提案中，我们旨在描述多巴胺在 LHA 中的作用和 检验 LHA 从多巴胺神经元接收预测误差信号的假设 腹侧被盖区。该提案中的实验将揭示一种新颖的神经回路 定义多巴胺在进食行为中的新作用。