The Exposome in Rheumatoid Arthritis and Systemic Lupus Erythematosus: EXACT Network Planning

类风湿关节炎和系统性红斑狼疮的暴露组：精确的网络规划

• 批准号: 10869439
• 负责人: JILL M NORRIS
• 金额: $ 44.9万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10869439
• 关键词: Address; Advocate; Air Pollution; Antibodies; Area; Autoantibodies; Autoimmune; Autoimmune Diseases; Autoimmunity; Biological; Biological Markers; Biomedical Research; Chemicals; Chronic; Climate; Clinical; Collaborations; Colorado; Complex; Data; Data Analyses; Data Collection; Databases; Development; Diet; Disease; Environmental Exposure; Environmental Risk Factor; Etiology; Evolution; Exhibits; Exploratory/Developmental Grant; Food; Foundations; Future; Genes; Genetic; Genetic Risk; Goals; Health Food; Hormones; Human Herpesvirus 4; Individual; Inflammation; Inflammatory; Infrastructure; Interdisciplinary Study; Laboratories; Life Cycle Stages; Measurement; Measures; Medical; Medical Research; Methods; Natural History; Obesity; Occupational; Oklahoma; Omega-3 Fatty Acids; Outcome; Patients; Pesticides; Phase; Plasma; Policies; Population; Prevention; Process; Professional Organizations; Prospective Studies; Prospective cohort; Psychosocial Stress; Questionnaires; Recording of previous events; Registries; Research; Research Personnel; Research Project Grants; Resolution; Resources; Rheumatoid Arthritis; Risk; Role; Sampling; Science; Severity of illness; Silicon Dioxide; Site; Smoking; Societal Factors; Source; Systemic Lupus Erythematosus; Techniques; Testing; Translations; Universities; Vitamins; Weather; Work; chemokine; clinical development; cohort; cytokine; data integration; design; disorder risk; epidemiology study; gut microbiome; health care availability; lipid mediator; lung microbiome; novel; oral microbiome; peripheral blood; pre-clinical; prospective; repository; seropositive; social; symposium

PROJECT SUMMARY This is an exploratory developmental grant aimed at the design, development, and implementation of a future national, interdisciplinary, collaborative, team science research network that will advance the study of the exposome in autoimmune diseases (Exposome in Autoimmune Diseases Collaborating Teams, EXACT). We propose to plan a study of the exposome during the pre-clinical period of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We assert that it is important to measure the exposome prior to the development of disease to ensure that what we are measuring precedes the disease and is not a consequence of the disease (which might happen if the exposome were measured in diseased individuals). This will allow us to draw inference about the temporality and potential causality of exposures on the risk of RA and SLE. This can be accomplished using prospective cohorts of at-risk individuals that are followed for the development of clinical disease (ie classifiable RA and SLE) with which we have a long history of working. Investigators at the University of Colorado Anschutz Medical Campus (Norris, Holers and Abraham) will work with investigators at the Oklahoma Medical Research Foundation (James and Munroe) to conduct a landscape analysis of relevant existing 1) resources, populations, databases, registries, repositories and consortia, 2) data on relevant exposures, 3) exposome laboratories, and 4) exposome analytic techniques. This will provide a background that we will use to plan activities for a new project to study the exposome in RA and SLE. As part of the planning process, we will hold a summit of exposome experts and investigators with cohorts/populations of individuals at-risk for RA and SLE, to develop and expand existing research collaborations to conduct a prospective study in the exposome of these diseases. We will use our existing novel cohorts of at-risk individuals who have been followed to the development of classifiable RA and SLE to explore feasibility of harmonization of questionnaire and biomarker data and conduct secondary data analysis to support the hypothesis and research strategy of the future EXACT Network. We will engage stakeholders such as scientific or professional associations and patients and patient-advocates in the areas of RA and SLE for better translation to inform the EXACT Network research agenda. The overall goal of this proposal is to plan research strategies and develop partnerships, infrastructure, and capabilities needed to address the major goals of a future collaborative EXACT network and to develop a research framework and strategies to support coordination among studies, collaborative research projects, and sites. Specific Aim 1. To conduct a multipronged approach to determine the needs and currently available resources to prospectively and effectively measure the exposome in RA and SLE (via a landscape analysis). Specific Aim 2. To design a prospective study to examine the role of the exposome in the etiology of RA and SLE, with an interdisciplinary research team, rigorous exposome measurements and novel analytic approaches.

项目概要 这是一项探索性发展拨款，旨在设计、开发和实施未来 国家、跨学科、协作、团队科学研究网络，将推进该研究 自身免疫性疾病中的暴露体（自身免疫性疾病合作团队中的暴露体，EXACT）。我们 提议计划对类风湿性关节炎（RA）临床前阶段的暴露组进行研究，并且 系统性红斑狼疮（SLE）。我们断言，在测试之前测量暴露组非常重要 疾病的发展，以确保我们测量的是疾病发生之前的结果，而不是疾病的结果 疾病（如果在患病个体中测量暴露组，则可能会发生这种情况）。这将使我们 推断暴露对 RA 和 SLE 风险的暂时性和潜在因果关系。这 可以通过使用高危个体的前瞻性队列来完成，并跟踪这些个体的发展 我们在临床疾病（即可分类的 RA 和 SLE）方面有着悠久的工作历史。调查人员在 科罗拉多大学安舒茨医学校区（Norris、Holers 和 Abraham）将与以下机构的研究人员合作 俄克拉荷马州医学研究基金会（James 和 Munroe）对相关领域进行景观分析 现有 1) 资源、群体、数据库、登记册、存储库和联盟，2) 相关数据 暴露，3) 暴露组实验室，以及 4) 暴露组分析技术。这将提供背景 我们将用它来规划一个新项目的活动，以研究 RA 和 SLE 中的暴露组。作为 在规划过程中，我们将举行一次由暴露组专家和研究人员组成的峰会 有 RA 和 SLE 风险的个人，发展和扩大现有的研究合作，以开展 暴露这些疾病的前瞻性研究。我们将利用现有的高危新人群 跟踪开发可分类 RA 和 SLE 的个人，以探索 协调问卷和生物标志物数据并进行二次数据分析以支持 未来EXACT网络的假设和研究策略。我们将让利益相关者参与其中，例如科学界 或 RA 和 SLE 领域的专业协会以及患者和患者倡导者，以便更好地 翻译以告知 EXACT 网络研究议程。该提案的总体目标是规划研究 战略并发展实现主要目标所需的伙伴关系、基础设施和能力 未来的协作 EXACT 网络并制定研究框架和策略来支持 研究、合作研究项目和地点之间的协调。具体目标 1. 开展 多管齐下的方法来确定未来和未来的需求和当前可用的资源 有效测量 RA 和 SLE 中的暴露组（通过景观分析）。具体目标 2. 设计一个 跨学科研究，探讨暴露组在 RA 和 SLE 病因学中的作用的前瞻性研究 研究团队、严格的暴露组测量和新颖的分析方法。