Training in the Design and Development of Infectious Disease Therapeutics

传染病治疗药物设计和开发培训

• 批准号: 10617855
• 负责人: Richard E. Lee
• 金额: $ 16.93万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-08 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617855
• 关键词: Communicable Diseases; Development; Therapeutic; Training; design

Project Summary/Abstract Infectious diseases remain the leading cause of death of children worldwide. New therapeutics are urgently needed to replace current treatments that are being compromised by drug resistance and emerging threats. The current COVID-19 pandemic perfectly illustrates the urgency. St. Jude Children’s Research Hospital (SJCRH) is the ideal pediatric research and treatment center to train postdoctoral fellows in this effort. The hospital’s translational and collaborative research environment combined with its expertise and infrastructure have a proven track record of successful therapeutic development. Our pediatric patients, particularly those treated for cancer, are typically immunocompromised and are at risk from a wide variety of infectious agents and pathogens that evolve more rapidly without immune clearance. SJCRH has developed an internationally recognized infectious disease program that dates from its establishment over 50 years ago. This program includes major research efforts in therapeutic and prophylactic strategies for bacterial, viral and fungal infectious agents. The training program leverages these strengths and the strong history of developing new therapeutics to provide unique and enhanced research training to postdoctoral fellows. The 16 preceptors in the program are from the departments of Infectious Diseases, Structural Biology, Chemical Biology & Therapeutics, Immunology and Pharmaceutical Sciences. They bring complementary expertise to this enterprise that not only seeks to understand the biology of infection but also strives to develop therapies to combat them. This expertise includes drug discovery, high-throughput screening, medicinal chemistry, immune responses to infection and therapies, and vaccine platforms and adjuvants. These efforts are linked to on-site best in class capabilities in GMP manufacturing and clinical trials. The broad goals of the program are to characterize pathogenic mechanisms, identify targets for therapeutic intervention, and develop vaccines and lead drug compounds that progress through the state-of-the-art therapeutics development infrastructure into safe and effective medicines. Collaborations between the preceptors provide a cross-disciplinary approach to the training program. In addition, 4 clinical collaborators will provide training in patient care, clinical trials and international medicine, and 5 training collaborators will provide training in specialized techniques. All trainees will be instructed in grant writing, rigor and reproducibility, ethics and mentoring. Interactions with pharmaceutical companies and visits to international sites in conjunction with the SJCRH Global Program are integral parts of the curriculum. To promote independence, trainees will develop their own research projects guided by a ‘team’ of mentors and apply for independent funding. We request support for three postdoctoral trainees, and the program will continue its efforts to recruit URM trainees by providing institutional support for an additional URM trainee. Finally, a formal evaluation process led by an External Advisory Committee has been established to track success and identify areas for improvement.

项目概要/摘要 传染病仍然是全世界儿童死亡的主要原因，迫切需要新的治疗方法。 需要取代目前因耐药性和新出现的威胁而受到损害的治疗方法。 当前的 COVID-19 大流行充分说明了圣裘德儿童研究医院的紧迫性。 （SJCRH）是培训博士后研究员的理想儿科研究和治疗中心。 医院的转化和协作研究环境与其专业知识和基础设施相结合 我们的儿科患者，尤其是儿科患者，拥有成功的治疗开发记录。 接受癌症治疗，通常免疫功能低下，并且面临多种传染源的风险 SJCRH 已在国际上开发了一种快速进化的病原体。 公认的传染病计划，其成立已有 50 多年的历史。 包括细菌、病毒和真菌的治疗和预防策略方面的主要研究工作 该培训计划利用了这些优势以及开发新传染媒介的悠久历史。 疗法为博士后研究员提供独特和强化的研究培训。 该项目来自传染病、结构生物学、化学生物学和 他们为此带来了治疗学、免疫学和制药科学的互补专业知识。 该企业不仅致力于了解感染的生物学，还致力于开发治​​疗方法 这些专业知识包括药物发现、高通量筛选、药物化学、 对感染和治疗的免疫反应，以及疫苗平台和佐剂。 GMP 制造和临床试验方面的现场一流能力 该计划的总体目标。 的目的是确定致病机制的特征，确定治疗干预的目标，并开发 通过最先进的疗法取得进展的疫苗和先导药物化合物 导师之间的合作将基础设施开发成安全有效的药物。 提供跨学科方法的培训计划此外，4 名临床合作者将提供。 患者护理、临床试验和国际医学方面的培训，5 名培训合作者将提供 所有学员都将接受有关资助写作、严谨性和可重复性以及道德方面的培训。 与制药公司的互动以及联合访问国际场所。 SJCRH 全球计划是课程的组成部分。为了促进独立性，学员将学习。 在导师“团队”的指导下开发自己的研究项目并申请独立资助。 请求支持三名博士后实习生，项目将继续努力招募URM实习生 最后，由一名 URM 实习生领导正式的评估流程。 已成立外部咨询委员会来跟踪成功情况并确定需要改进的领域。

项目成果

Persistent Infections with Diverse Co-Circulating Astroviruses in Pediatric Oncology Patients, Memphis, Tennessee, USA.

美国田纳西州孟菲斯市儿科肿瘤患者中多种共循环星状病毒的持续感染。

• 发表时间: 2017-02
• 影响因子: 11.8
• 作者: Cortez, Valerie;Freiden, Pamela;Gu, Zhengming;Adderson, Elisabeth;Hayden, Randall;Schultz
• 通讯作者: Schultz

The role of goblet cells in viral pathogenesis.

杯状细胞在病毒发病机制中的作用。

• 发表时间: 2021
• 作者: Cortez, Valerie;Schultz
• 通讯作者: Schultz

Development of a Universal Influenza Vaccine.

通用流感疫苗的开发。

• 发表时间: 2019
• 作者: Estrada, Leonardo D;Schultz
• 通讯作者: Schultz

Astrovirus Pathogenesis.

星状病毒发病机制。

• 发表时间: 2017-01-22
• 作者: Johnson, Cydney;Hargest, Virginia;Cortez, Valerie;Meliopoulos, Victoria A;Schultz
• 通讯作者: Schultz

Host Fatty Acid Utilization by Staphylococcus aureus at the Infection Site.

感染部位金黄色葡萄球菌对宿主脂肪酸的利用。

• 发表时间: 2020
• 影响因子: 6.4
• 作者: Frank, Matthew W;Yao, Jiangwei;Batte, Justin L;Gullett, Jessica M;Subramanian, Chitra;Rosch, Jason W;Rock, Charles O
• 通讯作者: Rock, Charles O