NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing

基于 NMR 的快速流体评估：设备设计和信号处理

基本信息

批准号：
10617808
负责人：
Michael J Cima
金额：
$ 54.1万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-05 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10617808
关键词：
Affect Algorithms Blood Pressure Body Weight decreased Cardiovascular system Cell Nucleus Clinical Clinical Research Clinical Trials Clinical assessments Collaborations Custom Data Dehydration Development Device Designs Devices Diagnostic Dialysis patients Dialysis procedure Disease End stage renal failure Engineering Excision Exclusion Exercise Extracellular Fluid Fluid Balance Fluid Shifts Fluid overload Future Goals Headache Health Heart Hemodialysis Hospitalization Hour Human Hypovolemia Hypovolemics Individual Institution Intramuscular Kidney Kidney Diseases Laboratories Leg Liquid substance Magnetic Resonance Magnetic Resonance Imaging Maintenance Measurement Measures Methods Moderate Exercise Morbidity - disease rate Muscle Muscle Cramp Nature Noise Organ Outcome Participant Patients Physicians Physiologic pulse Population Quality of Care Quality of life Research Resources Scientist Shapes Side Signal Transduction Skeletal Muscle Soldier Subcutaneous Tissue Surface Target Populations Technology Therapeutic Time Tissues Validation Water Work associated symptom clinical decision-making clinically relevant design experience fabrication improved improved outcome in vivo magnetic field mobile sensor mortality multidisciplinary point of care portability radio frequency response sensor signal processing skeletal muscle differentiation subcutaneous tool

项目摘要

NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing PROJECT SUMMARY Our goal is to develop a portable, non-invasive, measurement of volume status to improve quality of life and reduce morbidity and mortality among hospitalized patients. Maintenance of euvolemic status and proper fluid balance are critical for health and improved outcomes for renal, cardiovascular, and many other disease types as well as in healthy populations prone to dehydration such as athletes and soldiers. Our laboratory has previously constructed a portable single sided magnetic resonance (MR) sensors that is capable of resolving individual fluid compartments (subcutaneous, intramuscular, etc.) within tissue. This sensor was used in a pilot clinical trial with end stage kidney disease patients. Quantitative MRI results on these patients demonstrated that the first sign of fluid overload among hemodialysis patients is an expanded skeletal muscle extracellular fluid (ECF) space. The early stage nature of the technology was evident in that study as the portable sensor could not unambiguously differentiate skeletal muscle tissue from subcutaneous tissue. The proposed research includes the design of a new portable low-field MR sensor and improved signal processing that will allow it to capture the same quantitative assessment of volume status currently achievable with quantitative MRI (qMRI). We measure local fluid distribution in the target in vivo tissue compartment. In the case of fluid volume status, our hypothesis is that a localized skeletal muscle measurement is representative of systemic fluid distribution based on results from a prior study1. The optimized sensor will have the sensitive region of the magnetic field designed to target the skeletal muscle. The existing and newly designed portable MR sensors will be used to measure intramuscular fluid distribution in end stage kidney disease patients undergoing dialysis treatment as well as in healthy athletes experiencing exercise induced fluid loss. The sensor measurement will allow for quantification of volume overload (hypervolemia) or depletion (hypovolemia) and allow for its use in clinical decision making. Dialysis patients and athletes are the target population for the following proposal. The rapid reduction in fluid volume during a dialysis session and exercise respectively provides the ideal clinical context for performing repeated fluid status measurements.

基于 NMR 的快速流体评估：设备设计和信号处理项目概要我们的目标是开发一种便携式、非侵入性的体积状态测量方法，以提高质量生命并降低住院患者的发病率和死亡率。维持血容量正常状态和适当的液体平衡对于健康和改善肾脏、心血管疾病和许多其他疾病类型以及容易发生的健康人群脱水，例如运动员和士兵。我们的实验室之前已经构建了一个便携式能够解析单个流体的单侧磁共振 (MR) 传感器组织内的隔室（皮下、肌内等）。该传感器用于飞行员终末期肾病患者的临床试验。这些患者的定量 MRI 结果研究表明，血液透析患者液体超负荷的第一个迹象是液体超负荷的扩大骨骼肌细胞外液（ECF）空间。该技术的早期阶段性质是该研究中很明显，因为便携式传感器无法明确地区分骨骼肌来自皮下组织的组织。拟议的研究包括设计一种新型便携式低场 MR 传感器和改进的信号处理，使其能够捕获相同的定量评估目前可通过定量 MRI (qMRI) 实现体积状态。我们测量局部液体分布在目标体内组织区室中。在液体量状态的情况下，我们的假设是局部骨骼肌测量代表全身液体基于先前研究结果的分布1。优化后的传感器将具有灵敏旨在针对骨骼肌的磁场区域。现有的和新建的设计的便携式 MR 传感器将用于测量末期肌内液体分布接受透析治疗的肾病患者以及正在经历的健康运动员运动引起的体液流失。传感器测量将允许量化体积过载（高血容量）或耗尽（低血容量）并允许其在临床决策中使用制作。透析患者和运动员是以下提案的目标人群。这透析期间和运动期间液体量的快速减少分别提供了进行重复体液状态测量的理想临床环境。