PRE-CLINICAL AND CLINICAL MULTIPURPOSE PREVENTION TECHNOLOGIES

临床前和临床多用途预防技术

• 批准号: 10924372
• 负责人: JIM TURPIN
• 金额: $ 2.49万
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-28 至 2024-08-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10924372
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Anti-Infective Agents; Authorization documentation; Award; Characteristics; Clinical; Clinical Research; Contraceptive Agents; Contraceptive methods; Contracts; Development; Drug Combinations; Drug Delivery Systems; Effectiveness; Event; Experimental Designs; Funding; Goals; Government; Grant; HIV; Individual; Knowledge; Male Contraceptive Agents; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; Pattern; Perception; Persons; Pharmaceutical Preparations; Pregnancy; Prevention; Property; Reproductive Health; Research; Safety; Services; Sexual Health; Sexually Transmitted Diseases; Technology; Woman; authority; biophysical properties; drug action; experience; insight; men; pre-clinical; pregnancy prevention; prevent; programs; skills; uptake

NICHD supports a broad range of contraceptive research, including efforts to develop male contraceptives and Multipurpose Prevention Technologies (MPTs). MPT products that prevent both pregnancy and sexually transmitted infections (STIs) would increase sexual and reproductive health options for both women and men. MPTs are composed of a combination of drugs that can target prevention of pregnancy, STIs and/or HIV, delivered using either an on-demand and event-driven or long-acting drug delivery system (DDS) with rheological/biophysical properties and product user perceptions (look, feel, effectiveness, safety and duration of action) that support user uptake (first use, subsequent use and habitual use). By combining prevention products for pregnancy and HIV or STI, the MPT may have a greater uptake and adherence than individual products. Key to the concept of MPTs is creation of DDS to support convenience of use, that not only are safe and deliver the drugs consistently but have durations of action relevant to the user needs. MPTs (contraceptive and non-contraceptive) may encompass a wide range of delivery durations and use patterns from on demand, event-driven or sustained/extended-release durations (months to years).

NICHD 支持广泛的避孕研究，包括开发男性避孕药和多用途预防技术 (MPT)。 预防怀孕和性传播感染 (STI) 的 MPT 产品将增加女性和男性的性健康和生殖健康选择。 MPT 由多种药物组合组成，可针对预防怀孕、性传播感染和/或艾滋病毒，使用具有流变/生物物理特性和产品使用者的按需、事件驱动或长效药物输送系统 (DDS) 进行输送支持用户吸收（首次使用、后续使用和习惯使用）的看法（外观、感觉、有效性、安全性和作用持续时间）。通过结合针对妊娠和艾滋病毒或性传播感染的预防产品，MPT 可能比单独的产品有更高的采用率和依从性。 MPT 概念的关键是创建 DDS 以支持使用便利性，它不仅安全且持续提供药物，而且具有与用户需求相关的作用持续时间。 MPT（避孕药和非避孕药）可能涵盖广泛的给药持续时间和使用模式，从按需、事件驱动或持续/延长释放持续时间（数月到数年）。